A novel approach to avoid capping and/or lamination by application of external lower punch vibration

Kalies, Alexander; Heinrich, Thomas; Leopold, Claudia

doi:10.1016/j.ijpharm.2020.119195

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…The function of the lubricant is to ensure that tablet formation and ejection can occur with low friction between the granules and the die wall. High friction during tableting can cause a series of problems, including capping or even fragmentation of tablets during ejection and vertical scratches on tablet edges which may lead to abrupt halt in production (Kalies, Heinrich, Leopold, 2020). Lubricants are thus included in almost all tablet formulations.…”

Section: Optimization Of the Extragranular Excipient Composition Of P...mentioning

confidence: 99%

Optimization of the Extragranular Excipient Composition of Paracetamol Tablet formulation using the Quality by Design Approach

Apeji

Ariko

Olayemi

et al. 2022

Braz. J. Pharm. Sci.

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The purpose of this study is to optimize the composition of extragranular excipients (EGE) and mixing time of granules with EGE of paracetamol tablet formulation using Design of Experiments (DoE) approach. The effect of the composition of EGE and the mixing time of granules with EGE on granule and tableting properties of paracetamol tablet formulation was investigated using a combined model of mixture and process factors (Design-Expert 12). A total of 18 tablet formulations were manufactured by wet granulation using varying compositions of EGE and varying mixing time. Granule and tablet properties of each formulation were evaluated as response variables for the design, data generated were fitted into models and analysed to generate a design space that was used for optimization studies. The proposed EGE composition as predicted by the design was confirmed and validated after preparation and evaluation of the granule and tablet properties. The optimized composition for the EGE that yielded granules and tablets of desirable characteristics was found to be maize starch (5 %), talc (4.9 %) and magnesium stearate (0.1 %) with a mixing time of 2 min. The tablets produced with the optimized composition had better mechanical strength and disintegration time than the formulation prepared using an existing formula of maize starch (7.8 %), talc (2 %) and magnesium stearate (0.2 %) that were obtained using the One Variable at a Time (OVAT) approach. This study confirmed the relevance of quality by design in development of pharmaceutical formulations.

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Section: Optimization Of the Extragranular Excipient Composition Of P...mentioning

confidence: 99%

Optimization of the Extragranular Excipient Composition of Paracetamol Tablet formulation using the Quality by Design Approach

Apeji

Ariko

Olayemi

et al. 2022

Braz. J. Pharm. Sci.

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show abstract

“…12) Kalies et al proposed that a non-uniform particle shape, combined with a broad particle size distribution and poor powder flow, induces capping and lamination owing to entrapped air within the powder bed. 13) Bozic et al investigated the effect of dry granulation on compactibility and tablet capping tendency; granulation improved the compactibility and reduced the capping tendency owing to the strong bonding between the particles. 14) Akseli et al characterized the effective elastic and shear moduli of various tablets using an ultrasonic method.…”

Section: Introductionmentioning

confidence: 99%

Development of a Simple In-Die Method for Determination of Capping Tendency in Rotary Tableting Machines

Imayoshi

Ohsaki

Nakamura

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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A rotary tableting machine is used for the continuous tableting process. Tableting conditions often result in capping, leading to serious problems during production. Several studies have been conducted to predict the tablet capping tendency. However, as most previous studies were conducted using a compaction simulator, there is a lack of technology that can be readily applied during actual production. Therefore, the present study aimed to develop a novel method for predicting tablet capping in a rotary tableting machine. We hypothesized that capping occurs when residual stress of the tablet inside a die exceeds the critical stress immediately before ejection.Residual stress was evaluated by measuring the in-line die-wall pressure in a rotary tableting machine. Additionally, critical stress was estimated from the tablet strength inside the die using the Rumpf's equation. The critical and residual stresses were compared to determine the capping tendency to some extent. The findings of this study will substantially contribute to the rapid detection of tablet capping during tablet production.

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“…One solution for these problems, imposing ultrasonic vibration during the compaction process. This method successfully was performed on compaction of metallic, 8,9 ceramic, 10,11 biomass, 12 medicine, 13,14 and polymeric materials. 15 Khasanov and Dvilis 10 reported that using ultrasonic vibration during pressing, increases density distribution uniformity by 20% and decreases density gradient by 35%.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of ultrasonic vibrations on the properties of press-and-sintered titanium

Fartashvand

Abedini

Abdullah

2022

Proceedings of the Institution of Mechanical Engineers, Part B:

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In this study, longitudinal ultrasonic vibration was superimposed during the compaction of titanium powders. Then, specimens were vacuum sintered at 1273 K for 120 min. In order to investigate vibration influence on physical/mechanical properties, density, shrinkage, and compression strength of sintered samples were measured. The influence of powder size, compaction pressure, and aspect ratio also were studied on mentioned physical properties. Improvement of fine powder sintered samples density due to applied ultrasonic is greater than coarse powders, although their compacted density is lower than coarse powders samples. Dimensional stability (in the opposite of shrinkage) in coarse powder is greater than fine powders so that shrinkage in fine powders decreases up to 12%. Compression strength is improved due to the application of ultrasonic vibration up to 64%.

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A novel approach to avoid capping and/or lamination by application of external lower punch vibration

Cited by 10 publications

References 41 publications

Optimization of the Extragranular Excipient Composition of Paracetamol Tablet formulation using the Quality by Design Approach

Optimization of the Extragranular Excipient Composition of Paracetamol Tablet formulation using the Quality by Design Approach

Development of a Simple In-Die Method for Determination of Capping Tendency in Rotary Tableting Machines

Influence of ultrasonic vibrations on the properties of press-and-sintered titanium

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