A Novel Approach to Formulate and Optimize Orally Disintegrating Tablets of Bambuterol Hydrochloride

Li, Qing; Hu, ong; Gu, Deliang; Hu, Qiaofeng; Zhang, Hailei; Yang, Xihua

doi:10.4172/2153-2435.1000216

Pharmaceut Anal Acta

2013

DOI: 10.4172/2153-2435.1000216

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A Novel Approach to Formulate and Optimize Orally Disintegrating Tablets of Bambuterol Hydrochloride

Qing Li¹,

ong Hu²,

Deliang Gu³

et al.

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2024

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Cited by 1 publication

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Optimization of Fast-Dissolving Tablets of Carvedilol Using 23 Factorial Design

KUSUMA,

KUMAR R.

2024

Int J App Pharm

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Objective: Optimization of carvedilol fast-dissolving tablets through a 23 factorial design employing starch hyaluronate as a new superdisintegrating agent. Methods: The esterification method was used for producing starch hyaluronate. A direct compression process was used to develop carvedilol tablets utilizing a mix of starch hyaluronate (SH) as a novel superdisintegrant, crospovidone, and sodium starch glycolate. The prepared tablets are analyzed for physical characteristics, drug dissolution, in vivo pharmacokinetic, and stability studies. Results: New superdisintegrant synthesized was a fine, free-flowing crystalline powder. In the DSC study, starch hyaluronate had no interaction with the drug. NMR and FTIR investigations supported the ester connection between starch and hyaluronic acid. CF2, the optimized formulation, had the shortest disintegration time of 26±2 seconds. The percentage of drugs dissolved in ten minutes from the optimized composition was 93.4±1.32%. The optimized composition achieved peak plasma concentration in a short time and demonstrated higher relative bioavailability for the drug. Conclusion: A formula containing a 5% concentration of starch hyaluronate was optimized and has a proper potential for application in the formulation of rapidly disintegrating tablets, in addition to improving clinical obedience throughout the efficacious treatment of hypertension.

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Optimization of Fast-Dissolving Tablets of Carvedilol Using 23 Factorial Design

KUSUMA,

KUMAR R.

2024

Int J App Pharm

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A Novel Approach to Formulate and Optimize Orally Disintegrating Tablets of Bambuterol Hydrochloride

Cited by 1 publication

References 9 publications

Optimization of Fast-Dissolving Tablets of Carvedilol Using 23 Factorial Design

Optimization of Fast-Dissolving Tablets of Carvedilol Using 23 Factorial Design

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