2022
DOI: 10.1098/rsob.210367
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A novel approach to the functional classification of retinal ganglion cells

Abstract: Retinal neurons are remarkedly diverse based on structure, function and genetic identity. Classifying these cells is a challenging task, requiring multimodal methodology. Here, we introduce a novel approach for retinal ganglion cell (RGC) classification, based on pharmacogenetics combined with immunohistochemistry and large-scale retinal electrophysiology. Our novel strategy allows grouping of cells sharing gene expression and understanding how these cell classes respond to basic and complex visual scenes. Our… Show more

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Cited by 5 publications
(3 citation statements)
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“…The first hypothesis appears unlikely as RGCs are widely studied, especially with the emergence of large-scale and high-density MEA recordings [ 6 ], but also using morphological and molecular characterizations. Thus, it is unlikely that the existence of dense On RGC types (representing the majority of the On population, and so being the most common On type) has not been captured by at least one of these techniques.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The first hypothesis appears unlikely as RGCs are widely studied, especially with the emergence of large-scale and high-density MEA recordings [ 6 ], but also using morphological and molecular characterizations. Thus, it is unlikely that the existence of dense On RGC types (representing the majority of the On population, and so being the most common On type) has not been captured by at least one of these techniques.…”
Section: Discussionmentioning
confidence: 99%
“…One approach is to classify them into three functional and morphological groups depending on the sub-layer their dendrites laminate into in the inner plexiform layer, forming the On, Off and On-Off groups. In mouse, RGCs can however be divided into more than 40 types [3][4][5][6], each having different functional and anatomical characteristics. The number of RGCs sub-group varies between species, and for a different species, the density of these sub-groups is also known to greatly differ, varying from less than 50 cells mm −2 to more than 300 cells mm −2 [5].…”
Section: Introductionmentioning
confidence: 99%
“…A key hypothesis in these more recent methods is that two neurons of the same type should extract the same feature, but in a different location of the visual space. For this reason, they should respond the same way if a stimulus that is spatially uniform is displayed [1], or if the stimulus is re-centered on the receptive field for each cell [3,5,9,11]. One of the most recent attempts to classify all ganglion cell types based on their function used, among other features, the responses to this spatially uniform "chirp" stimulus to divide cells in different types [1].…”
Section: Introductionmentioning
confidence: 99%