A Novel Bacterium, Butyricimonas virosa, Preventing HFD-Induced Diabetes and Metabolic Disorders in Mice via GLP-1 Receptor

Lee, Heetae; An, Jinho; Kim, Jiyeon; Choi, Dong Lak; Song, Youngcheon; Lee, Chong-Kil; Kong, Hyunseok; Kim, Sang Bum; Kim, Kyungjae

doi:10.3389/fmicb.2022.858192

Cited by 32 publications

(18 citation statements)

References 43 publications

(47 reference statements)

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“…Interestingly, although a positive correlation with BPH indicators was confirmed, Butyricimonas abundance was further increased by finasteride treatment. Despite recent reports on the positive effects of Butyricimonas [ 33 ], the abundance of Butyricimonas was consistently positively correlated with BPH markers in our study. Therefore, further studies are required.…”

Section: Discussioncontrasting

confidence: 99%

“…They have been reported to aggravate metabolic disorders in diabetic patients in relation to their energy metabolism and insulin sensitivity [ 32 ]. Butyricimonas has been reported to improve hyperglycemia through the regulation of GLP-1R in mice fed a high-fat diet and to be associated with lipid metabolism [ 33 , 34 , 35 ]. The increased abundance of Anaerotruncus is directly related to an increase in inflammatory cytokines due to aging [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

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Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model

Song

Kim

et al. 2023

IJMS

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Gut microbes are closely associated with disease onset and improvement. However, the effects of gut microbes on the occurrence, prevention, and treatment of benign prostatic hyperplasia (BPH) are still unclear. We investigated the alteration of gut microbiota with implications for the diagnosis, prevention, and treatment of BPH and identified correlations among various indicators, including hormone indicators, apoptosis markers in BPH, and finasteride treatment models. BPH induction altered the abundance of Lactobacillus, Flavonifractor, Acetatifactor, Oscillibacter, Pseudoflavonifractor, Intestinimonas, and Butyricimonas genera, which are related to BPH indicators. Among these, the altered abundance of Lactobacillus and Acetatifactor was associated with the promotion and inhibition of prostate apoptosis, respectively. Finasteride treatment altered the abundance of Barnesiella, Acetatifactor, Butyricimonas, Desulfovibrio, Anaerobacterium, and Robinsoniella genera, which are related to BPH indicators. Among these, altered abundances of Desulfovibrio and Acetatifactor were associated with the promotion and inhibition of prostate apoptosis, respectively. In addition, the abundances of Lactobacillus and Acetatifactor were normalized after finasteride treatment. In conclusion, the association between apoptosis and altered abundances of Lactobacillus and Acetatifactor, among other gut microbes, suggests their potential utility in the diagnosis, prevention, and treatment of BPH.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model

Song

Kim

et al. 2023

IJMS

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“…Treatment of metabolic disorders with metformin and statins has been shown to significantly increase the relative abundance of Butyricimonas in the gut, and this has been significantly associated with metabolic parameters [ 60 , 61 ]. Lee et al reported that Butyricimonas could prevent high fat diet-induced diabetes and metabolic disorders in mice via the GLP-1 receptor [ 62 ]. Butyricimonas has also been negatively correlated with insulin resistance and obesity in humans [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases

Liu

Peng²,

Hung

et al. 2023

IJMS

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Gut dysbiosis can induce chronic inflammation and contribute to atherosclerosis and vascular calcification. The aortic arch calcification (AoAC) score is a simple, noninvasive, and semiquantitative assessment tool to evaluate vascular calcification on chest radiographs. Few studies have discussed the relationship between gut microbiota and AoAC. Therefore, this study aimed to compare the microbiota composition between patients with chronic diseases and high or low AoAC scores. A total of 186 patients (118 males and 68 females) with chronic diseases, including diabetes mellitus (80.6%), hypertension (75.3%), and chronic kidney disease (48.9%), were enrolled. Gut microbiota in fecal samples were analyzed by sequencing of the 16S rRNA gene, and differences in microbial function were examined. The patients were divided into three groups according to AoAC score, including 103 patients in the low AoAC group (AoAC ≤ 3), 40 patients in the medium AoAC group (3 < AoAC ≤ 6), and 43 patients in the high AoAC group (AoAC > 6). Compared to the low AoAC group, the high AoAC group had a significantly lower microbial species diversity (Chao1 index and Shannon index) and increased microbial dysbiosis index. Beta diversity showed that the microbial community composition was significantly different among the three groups (p = 0.041, weighted UniFrac PCoA). A distinct microbial community structure was found in the patients with a low AoAC, with an increased abundance at the genus level of Agathobacter, Eubacterium coprostanoligenes group, Ruminococcaceae UCG-002, Barnesiella, Butyricimonas, Oscillibacter, Ruminococcaceae DTU089, and Oxalobacter. In addition, there was an increased relative abundance of class Bacilli in the high AoAC group. Our findings support the association between gut dysbiosis and the severity of AoAC in patients with chronic diseases.

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“…This genus has been positively associated with the adoption of a high-fat diet [158], but also with normal BMIs in another study [159]. Moreover, the B. virosa species has previously been stated to have a beneficial effect on obesity and T2D by promoting SCFA production [160] and thus the secretion of the glucagon-like peptide-1 (GLP-1) [161], an incretin that activates glucose-dependent insulin secretion and inhibits glucagon release [162]. Conversely, Sutterella , which was more abundant in the group with poorer HEIs, has been reported to be positively correlated with the likeness of developing T2D [163].…”

Section: Discussionmentioning

confidence: 99%

Uncovering the link between gut microbiome, highly processed food consumption and diet quality through bioinformatics methods

Molina

Lacruz-Pleguezuelos

Pau

et al. 2023

Preprint

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The consumption of highly processed foods, along with other dietary and lifestyle poor habits, has an impact on health by increasing the risk of several non-communicable pathologies, such as diabetes. Gut microbiome composition, in specific, can be modulated by nutrients, deriving in different metabolic outcomes that have an influence on this high disease susceptibility and making it a possible therapeutic target for these comorbidities. In this work, gut microbiome of 60 and 46 individuals from 2 different studies focused, among other aspects, on diet-microbiome interactions, was characterised. By means of differential abundance analyses and supervised machine learning techniques based on random forest, gradient boosting and support vector machines, a set of microbial genera that could be potential biomarkers for the differentiation of individuals with poorer dietary patterns was discovered, after comparing coincidences in these taxa among classifiers and testing them for significant differences. Among these, Dialister, Phocea and Pseudoflavonifractor were suggested to have a role in the way highly processed foods affect health negatively, along with Prevotellaceae NK3B31 group and an undetermined genus from Muribaculaceae in the opposite sense. Furthermore, all the identified genera in this study had already been linked to type 2 diabetes, among which Bacteroides and Pseudoflavonifractor proved to be differentially abundant in groups of individuals with different levels of biomarkers for this disease. Nevertheless, further research via longitudinal studies and experimental validation of these genera should be carried out to confirm the association of these taxa with diet and diabetes.

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A Novel Bacterium, Butyricimonas virosa, Preventing HFD-Induced Diabetes and Metabolic Disorders in Mice via GLP-1 Receptor

Cited by 32 publications

References 43 publications

Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model

Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model

Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases

Uncovering the link between gut microbiome, highly processed food consumption and diet quality through bioinformatics methods

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