A novel benzopyran-based colorimetric and near-infrared fluorescent sensor for Hg2+ and its imaging in living cell and zebrafish

Lv, Hehong; Yuan, Gang; Zhang, Ganbing; Ren, Ziqi; He, Hanping; Sun, Qi; Zhang, Xun; Wang, Shengfu

doi:10.1016/j.dyepig.2019.107658

Cited by 42 publications

(8 citation statements)

References 46 publications

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“…7,8 Moreover, once ingested by human bodies, Hg 2+ can result in a wide variety of severe health damages such as neural disorders, abdominal pain, kidney failure, hearing loss, Hunter-Russell syndrome, Minamata disease, pink disease, and even death. 9,10 WHO has explicitly stipulated that the level for Hg 2+ in drinking water should be less than 6 ppb (30 nM). 11 Consequently, developing efficient detection methods for sensitive and specific perception of Hg 2+ in an environment and living cells is an urgent demand.…”

Section: ■ Introductionmentioning

confidence: 99%

A Novel Camphor-Based “Turn-on” Fluorescent Probe with High Specificity and Sensitivity for Sensing Mercury(II) in Aqueous Medium and Its Bioimaging Application

Wang

Zhang

Yin

et al. 2020

ACS Sustainable Chem. Eng.

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Precise detection of Hg2+ in an ecological environment and biological system is of great importance. Hence, in this paper, we have constructed a simple fluorescent turn-on probe CP-Hg toward Hg2+ based on natural and renewable camphor. A significantly enhanced green fluorescence was clearly observed only with the participation of Hg2+ due to the Hg2+-mediated deprotection reaction of thioacetal. The probe CP-Hg could also sensitively detect Hg2+ with a detection limit of 19.3 nM and a large Stokes shift of 153 nm in a near-perfect aqueous solution. The reaction mechanism was fully analyzed through 1H NMR (proton nuclear magnetic resonance), ESI-MS (electrospray ionization mass spectrometry), and DFT (density functional theory) calculations. Moreover, the CP-Hg-coated test strips were successfully fabricated for naked-eye detection of Hg2+. Furthermore, the cell imaging experiment manifested that the probe CP-Hg is suitable for labeling intracellular Hg2+.

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Section: ■ Introductionmentioning

confidence: 99%

A Novel Camphor-Based “Turn-on” Fluorescent Probe with High Specificity and Sensitivity for Sensing Mercury(II) in Aqueous Medium and Its Bioimaging Application

Wang

Zhang

Yin

et al. 2020

ACS Sustainable Chem. Eng.

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“…Dicyanomethylene-benzopyran (DCMB) derivatives are well-known NIR fluorophores with good stability and large Stokes shifts owing to the distinct push-pull effect and extended π-conjugation, which are ideal platforms to construct potent NIR fluorescent sensors for various analytes [ 78 , 79 , 80 , 81 ]. Conjugation between DCMB and the skeleton of compound 5 ought to afford a unique fluorescent probe for HOBr.…”

Section: Coupling and Cyclization Of Amino And S-methyl Groups Catmentioning

confidence: 99%

Fluorescent Probes for Selective Recognition of Hypobromous Acid: Achievements and Future Perspectives

Fang

Dehaen

2021

Molecules

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Reactive oxygen species (ROS) have been implicated in numerous pathological processes and their homeostasis facilitates the dynamic balance of intracellular redox states. Among ROS, hypobromous acid (HOBr) has a high similarity to hypochlorous acid (HOCl) in both chemical and physical properties, whereas it has received relatively little attention. Meanwhile, selective recognition of endogenous HOBr suffers great challenges due to the fact that the concentration of this molecule is much lower than that of HOCl. Fluorescence-based detection systems have emerged as very important tools to monitor biomolecules in living cells and organisms owing to distinct advantages, particularly the temporal and spatial sampling for in vivo imaging applications. To date, the development of HOBr-specific fluorescent probes is still proceeding quite slowly, and the research related to this area has not been systematically summarized. In this review, we are the first to review the progress made so far in fluorescent probes for selective recognition and detection of HOBr. The molecular structures, sensing mechanisms, and their successful applications of these probes as bioimaging agents are discussed here in detail. Importantly, we hope this review will call for more attention to this rising field, and that this could stimulate new future achievements.

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“…The detection limit is 0.14 μM. For practical applications, sensor was applied for Hg 2+ detection in real aqueous samples and live cell imaging [ 120 ].…”

Section: Chromo-fluorogenic Chemosensorsmentioning

confidence: 99%

Mercury Toxicity and Detection Using Chromo-Fluorogenic Chemosensors

2021

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Mercury (Hg), this non-essential heavy metal released from both industrial and natural sources entered into living bodies, and cause grievous detrimental effects to the human health and ecosystem. The monitoring of Hg2+ excessive accumulation can be beneficial to fight against the risk associated with mercury toxicity to living systems. Therefore, there is an emergent need of novel and facile analytical approaches for the monitoring of mercury levels in various environmental, industrial, and biological samples. The chromo-fluorogenic chemosensors possess the attractive analytical parameters of low-cost, enhanced detection ability with high sensitivity, simplicity, rapid on-site monitoring ability, etc. This review was narrated to summarize the mercuric ion selective chromo-fluorogenic chemosensors reported in the year 2020. The design of sensors, mechanisms, fluorophores used, analytical performance, etc. are summarized and discussed.

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A novel benzopyran-based colorimetric and near-infrared fluorescent sensor for Hg2+ and its imaging in living cell and zebrafish

Cited by 42 publications

References 46 publications

A Novel Camphor-Based “Turn-on” Fluorescent Probe with High Specificity and Sensitivity for Sensing Mercury(II) in Aqueous Medium and Its Bioimaging Application

A Novel Camphor-Based “Turn-on” Fluorescent Probe with High Specificity and Sensitivity for Sensing Mercury(II) in Aqueous Medium and Its Bioimaging Application

Fluorescent Probes for Selective Recognition of Hypobromous Acid: Achievements and Future Perspectives

Mercury Toxicity and Detection Using Chromo-Fluorogenic Chemosensors

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