A novel bioactive glass-ceramic for treating dentin hypersensitivity

Abstract

Dentin hypersensitivity (DH) is a painful response to stimulus applied to the open dentinal tubules of a vital tooth. It's a common oral condition, however, without an ideal treatment available yet. This work evaluated in vitro the effect of micron-sized particles from a novel bioactive glass-ceramic (Biosilicate) in occluding open dentinal tubules. A dentin disc model was employed to observe comparatively, using scanning electron microscopy (SEM), dentinal tubule occlusion by different products and deposition of hydroxyl carbonate apatite (HCA) on dentin surface by Biosilicate, after a single application: G1 - Dentifrice with potassium nitrate and fluoride; G2 - Two-step calcium phosphate precipitation treatment; G3 - Water-free gel containing Biosilicate particles (1%); G4 - Biosilicate particles mixed with distilled water in a 1:10 ratio; all of them after 1, 12 and 24 hours of immersion in artificial saliva. Fourier transform infrared spectroscopy (FTIR) was performed to detect HCA formation on dentin discs filled with Biosilicate after 2 minutes, 30 minutes and 12 hours of immersion in artificial saliva. SEM showed a layer of HCA formed on dentin surface after 24 hours by G4. G1, G2 and G3 promoted not total occlusion of open dentinal tubules after 24 hours. FTIR showed HCA precipitation on the dentin surface induced by Biosilicate after 30 minutes. The micron-sized particles from the bioactive glass-ceramic thus were able to induce HCA deposition in open dentinal tubules in vitro. This finding suggests that Biosilicate may provide a new option for treating DH.

Dentin hypersensitivity after treatment with desensitizing agents: a randomized, double-blind, split-mouth clinical trial

“…Several treatment modalities and agents have been used in the management and resolution of dentin hypersensitivity, but their efficacy has varied from one study to another and it is not yet established in the literature (2,15,(20)(21)(22)(23). Further research is needed to clarify the mechanisms and etiology of this uncomfortable clinical condition.…”

Efffect of desensitizing agents on the bond strength of dental adhesive systems

“…Biosilicate® is among the derivatives of bioglasses with the original formulation (Na 2 -CaO-SiO 2 -P 2 O 5 ), but it also contains Li 2 O and K 2 O [18], and in nanoparticulate form (0.1 to 10 μm) in 10% solution, it was found to promote the obliteration of dentinal tubules when in contact with dentin for 24 hours [19]. Microscopic and spectrophotometric analysis suggested the formation of an adhesive layer of hydroxyapatite on the dentin surface that is hypothetically responsible for the permanent obliteration of dentinal tubules [20].…”

Efficacy of a bioactive material and nanostructured desensitizing on dentin hypersensitivity treatment

“…The fluoride gel was applied using a micro-applicator for 1 min on the exposed dentin surface. For bioactive material, a mixture of 0.100 g of powder with 1 mL of distilled water (1:10 ratio) was applied for 5 minutes 22,24 . Group 2 (G2): fluoride gel and nanostructured desensitizing (Desensibilize Nano P; FGM Dental Materials, Joinville, SC, Brazil).…”

“…This change results in particles with lower cutting potential and proven biological properties 20,21 , reducing dentin hypersensitivity 22 . Previous studies have shown that, after biosilicate application on the dentin, deposition of hydroxycarbonate apatite in open dentinal tubules was observed, forming a uniform layer over this surface 23,24 .…”