A novel biomimetic condensation of 2-deoxyribose, aryl amine and acetyl acetone to bicyclic aminols catalyzed by InCl3

Synthesis of imidazo[1,2-a]pyridin-chromones by a MW assisted Groebke–Blackburn–Bienaymé process

“…Thus, it has been reported that Lewis acids such as InCl 3 as catalysts increase the electrophilicity of aldehydes or ketones in their condensation reactions with low nucleophilic aromatic amines. 20 In this context, a catalytic amount of InCl 3 (1% mol) was added to promote the condensation between the 3-formylchromones 10 and the 2-aminopyridines 11. Moreover, it is well known that the high electrophilic iminium ions are obtained from imines through BrØnsted acid catalysis.…”

Chemistry and Biology Of Multicomponent Reactions

“…7). 23 The reaction typically leads to 1:1 mixtures of two diastereomers and shows considerable scope in the nature of the substitutents of the aniline component ( 20 ).…”

Synthesis of 1,5-disubstituted-1<em>H</em>-tetrazole methane-linked <em>bis</em>-heterocycles via Ugi-azide

“…It has been reported that Lewis acids favor the condensation between anilines with aldehydes or ketones. 21 In this context, InCl3 was used because compared to other Lewis acids has advantages such as being less toxic and hygroscopic and easy handling. However, yields were low probably due to the formation of a complex with the metal and the isocyanide.…”