Chemistry and Biology Of Multicomponent Reactions

Dömling, Alexander; Wang, Wei; Wang, Kan

doi:10.1021/cr100233r

Cited by 2,225 publications

(1,002 citation statements)

References 367 publications

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“…The Ugi four-component reaction (U-4CR), followed by various post-condensation transformations, is well known as a versatile and highly efficient synthetic strategy for the preparation of heterocyclic compounds [3]. Moreover, these multicomponent reactions (MCRs) provide facile access to complex products with high iterative efficiency potential [4], for the design of novel drug scaffolds from commercially available starting materials.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃

2017

Zeitschrift Für Kristallographie - New Crystal Structures

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CCDC no.: 1488220The asymmetric unit of the title crystal structure is shown in the figure. Atoms are shown with arbitrary radii. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of materialA solution of p-methoxybenzoylformic acid (1.0 mmol), benzyl isocyanide (1.0 mmol), aniline (1.0 mmol) and ethyl glyoxylate (1.0 mmol) was stirred overnight in MeOH (2.0 mL) at room temperature. The reaction mixture was monitored by TLC. When no isonitrile was left, the solvent was removed under nitrogen blowing and the crude residue was dissolved in DIPA (2.0 equiv.) and DMF (3.0 mL). This solution was

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Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃

2017

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Multicomponent reactions have emerged as powerful synthetic strategies because of their efficiency, atom economy, high selectivity and convenient construction of multiple new bonds. [79][80][81] These characteristics give rapid access to combinatorial libraries of complex organic molecules for efficient lead structure identification and optimization in drug discovery. [82][83][84] This section reviews three-, four and five-component reactions of isatins that have been employed in the synthesis of three-to seven membered spiro-heterocycles bearing one or more heteroatoms.…”

Section: Synthesis Involving Multicomponent Reactionsmentioning

confidence: 99%

Recent applications of isatin in the synthesis of organic compounds

Moradi¹,

Ziarani²,

Lashgari³

et al. 2017

Arkivoc

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“…[82][83][84] Acyl isothiocyanates have also been employed in multicomponent reactions to synthesize functionalized thiourea and heterocyles. A multicomponent reaction of benzoyl isothiocyanates 125, alkyl propiolates 126, secondary amines 127, and Ph 3 P leading to an efficient synthesis of functionalized thioureas has been reported.…”

Section: Multicomponent Reactions Of Acyl Isothiocyanatesmentioning

confidence: 99%

Reactivity and diverse synthetic applications of acyl isothiocyanates

Bedane¹,

Singh²

2015

Arkivoc

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Isothiocyanates constitute a group of heterocumulenes containing N=C=S functionality that is of immense importance in organic synthesis. The presence of carbonyl group in acyl isothiocyanates imparts unique reactivity to acyl isothiocyanates. The chemistry of acyl isothiocyanates, in particular, is very rich and diverse, and has been employed in synthesis of a number of biologically important heterocycles. This review article discusses the acyl isothiocyanate chemistry leading to the synthesis of biologically important heterocyclic skeletons. These include highly functionalized thiazoles, thiadiazoles, triazoles, benzimidazoles, dithiolane, spiro-fused oxazolines, triazines, and oxazines, etc. The role of acyl isothiocyanates as acylating agent and thiocyanate transfer reagent is also discussed.

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Chemistry and Biology Of Multicomponent Reactions

Cited by 2,225 publications

References 367 publications

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃

Recent applications of isatin in the synthesis of organic compounds

Reactivity and diverse synthetic applications of acyl isothiocyanates

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Chemistry and Biology Of Multicomponent Reactions

Cited by 2,225 publications

References 367 publications

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C24H19BrN2O3

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C24H19BrN2O3

Recent applications of isatin in the synthesis of organic compounds

Reactivity and diverse synthetic applications of acyl isothiocyanates

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Product

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Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃

Crystal structure of 1-benzyl-3-((4-bromophenyl)amino)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione, C₂₄H₁₉BrN₂O₃