A novel bioreducible and pH-responsive magnetic nanohydrogel based on β-cyclodextrin for chemo/hyperthermia therapy of cancer

Soleimani, Khadijeh; Arkan, Elham; Derakhshankhah, Hossein; Haghshenas, Babak; Jahanban‐Esfahlan, Rana; Jaymand, Mehdi

doi:10.1016/j.carbpol.2020.117229

Cited by 69 publications

(31 citation statements)

References 37 publications

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“…Thus, the GF values for the samples were calculated as 74 ± 2.1 and 73 ± 1.8, respectively. The results verified the efficient crosslinking and acceptable stability of the synthesized samples 34 …”

Section: Resultssupporting

confidence: 68%

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Derakhshankhah

Jahanban‐Esfahlan

Vandghanooni

et al. 2021

J of Applied Polymer Sci

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Gelatin (Gel)-based pH-and thermal-responsive magnetic hydrogels (MH-1 and MH-2) were designed and developed as novel drug delivery systems (DDSs) for cancer chemo/hyperthermia therapy. For this goal, Gel was functionalized with methacrylic anhydride (GelMA), and then copolymerized with (2-dimethylaminoethyl) methacrylate (DMAEMA) monomer in the presence of methacrylate-end capped magnetic nanoparticles (MNPs) as well as triethylene glycol dimethacrylate (TEGDMA; as crosslinker). Afterward, a thiolend capped poly(N-isopropylacrylamide) (PNIPAAm-SH) was synthesized through an atom transfer radical polymerization technique, and then attached onto the hydrogel through "thiol-ene" click grafting. The preliminary performances of developed MHs for chemo/hyperthermia therapy of human breast cancer was investigated through the loading of doxorubicin hydrochloride (Dox) as an anticancer agent followed by cytotoxicity measurement of drug-loaded DDSs using MTT assay by both chemo-and chemo/hyperthermia-therapies. Owing to porous morphologies of the fabricated magnetic hydrogels according to scanning electron microscopy images and strong physicochemical interactions (e.g., hydrogen bonding) the drug loading capacities of the MH-1 and MH-2 were obtained as 72 ± 1.4 and 77 ± 1.8, respectively. The DDSs exhibited acceptable pH-and thermal-triggered drug release behaviors. The MTT assay

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Section: Resultssupporting

confidence: 68%

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Derakhshankhah

Jahanban‐Esfahlan

Vandghanooni

et al. 2021

J of Applied Polymer Sci

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“…Moreover, it developed good activity as an antitumor strategy under hyperthermic conditions, especially in the highly aggressive human breast adenocarcinoma MDA-MB-231 cells. Nevertheless, for an enhanced antitumor effect, MCS as developed herein could be employed as hyperthermia tools in various magnetically responsive formulations containing antitumor agents that target breast cancer therapy, such as nanohydrogels [ 74 ], solid lipid nanoparticles [ 75 ], magnetoliposomes [ 76 , 77 ], or other smart carriers for the combined approach of hyperthermia and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells: Physicochemical Analysis and Complex In Vitro Biological Profile

et al. 2021

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Magnetic iron oxide nanoparticles are the most desired nanomaterials for biomedical applications due to their unique physiochemical properties. A facile single-step process for the preparation of a highly stable and biocompatible magnetic colloidal suspension based on citric-acid-coated magnetic iron oxide nanoparticles used as an effective heating source for the hyperthermia treatment of cancer cells is presented. The physicochemical analysis revealed that the magnetic colloidal suspension had a z-average diameter of 72.7 nm at 25 °C with a polydispersity index of 0.179 and a zeta potential of −45.0 mV, superparamagnetic features, and a heating capacity that was quantified by an intrinsic loss power analysis. Raman spectroscopy showed the presence of magnetite and confirmed the presence of citric acid on the surfaces of the magnetic iron oxide nanoparticles. The biological results showed that breast adenocarcinoma cells (MDA-MB-231) were significantly affected after exposure to the magnetic colloidal suspension with a concentration of 30 µg/mL 24 h post-treatment under hyperthermic conditions, while the nontumorigenic (MCF-10A) cells exhibited a viability above 90% under the same thermal setup. Thus, the biological data obtained in the present study clearly endorse the need for further investigations to establish the clinical biological potential of synthesized magnetic colloidal suspension for magnetically triggered hyperthermia.

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“…Khadijeh Soleimani et al reported a E-CD based magnetic drug release system (E-CD-g-(PEtOx)ၼ)/FeၸOၹ) which is both pH and reduction responsive [38]. The MTT method was used to test the antitumor activity of Dox-loaded magnetic nanohydrogel on MCF7 cells, and then the findings were checked with the antitumor activity of free Dox as a standard.…”

Section: Multiple Stimuli Responsive CD Based Materialsmentioning

confidence: 99%

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

et al. 2021

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In this review we discuss about the research advances in multiple stimuli responsive cyclodextrin (CD) based smart materials. CD based systems which are responsive to temperature, pH, enzymes, light, redox etc. along with various applications of these systems in the biomedical area are extensively covered. Current challenges and future perspectives of these smart stimuli-responsive drug delivery systems are also discussed.

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A novel bioreducible and pH-responsive magnetic nanohydrogel based on β-cyclodextrin for chemo/hyperthermia therapy of cancer

Cited by 69 publications

References 37 publications

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells: Physicochemical Analysis and Complex In Vitro Biological Profile

Multiple stimuli responsive cyclodextrin based smart materials for drug delivery: a review

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