A Novel Chalcone from Garcinia Nervosa

Abstract

A novel chalcone 5′-bromo-2′-hydroxy-4,4′,6′-trimethoxy-chalcone, isoliquiritigenin-4,4′-dimethyl ether (2′-hydroxy-4,4′-dimethoxy chalcone) and 2′-hydroxy-3,4,4′,6′-tetramethoxy dihydrochalcone have been isolated from the leaves of Garcinia nervosa. Their structure have been elucidated on the basis of chemical and spectral evidences ( 1 H NMR, 13 C NMR, HMQC, NOE, IR, UV and mass spectra).

Anthocyanins and other flavonoids

“…Additionally a halogenated simple chalcone, 5Ј-bromo-2Ј-hydroxy-4,4Ј,6Ј-trimethoxychalcone, has been reported from Garcinia nervosa (Guttiferae). 227 New prenylated chalcones were discovered in species belonging to only four different plant families: the Leguminosae (6 new structures), Moraceae (4), Rutaceae (2) and Ptaeroxylaceae (2). The prenylated legume chalcones include epoxyobovatachalcone (85), which was isolated from Tephrosia carrollii (formerly called T. woodii).…”

2, 4, 6-Trihidroksi Benzofenon dari Kulit Batang Garcinia balica Miq

“…Tumbuhan ini merupakan salah satu genus terbesar dengan 400 spesiesnya tersebar luas di kawasan tropis Asia, Kaledonia Baru dan Polinesia [3]. Penelitian mengenai kandungan kimia dari genus Garcinia telah banyak dilakukan, diantaranya adalah guttiferones Q-S [4], 5'-bromo-2'-hidroksi-4, 4; 6'trimetoksi chalkon [5], dulcisoflavon [6]. Genus ini dilaporkan banyak kandungan senyawa santon teroksigenasi dan terprenilasi [7].…”

Polyisoprenylated Acylphloroglucinols from Garcinia nervosa

“…Phytochemically, this genus is mostly known for its unique prenylated xanthones and benzophenones [2,[4][5][6][7][8][9][10][11], though triterpenoids [12,13] and flavonoids [14] were also reported. The leaves G. nervosa have been reported to contain biflavonoids and chalcones [15][16][17][18]. The leaves extract of G. nervosa has also been reported to show cytotoxic activity against HeLa, MCF-7, and HT-29 cell lines, however its bioactive constituents were not reported [19].…”