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Being an attractive class of naturally occurring molecules with fascinating properties sugars and their derivatives have wide applications in different fields especially in drug discovery. Due to their highly diverse nature they play various important key roles in biological systems. In terms of providing both desirable structural diversity and compound libraries, multicomponent reactions (MCRs) are most efficient strategies. MCRs are widely employed by chemists to generate sugar based derivatives with significantly extended variations having various benefits to society. The advances in the synthesis of structurally diversified sugar based derivatives through new MCRs of the previous decade are reviewed. Scheme 2 Ugi-MCR based synhesis of divalent neoglycoconjugates where diacid acting as bridge. Scheme 3 Four component synthesis of N-glycosyl-Asp-urea conjugate. Scheme 4 Multicomponent reaction with symmetric and asymmetric carbodiimide. 57886 | RSC Adv., 2015, 5, 57883-57905 This journal is Scheme 13 Synthesis of thiosugar annulated dihydropyrimidines 63 and 64. Scheme 14 Complementry Mannich and Reformatsky route for the synthesis of C-glycosyl aminoesters. Scheme 15 Synthesis of furanose C-nucleoside enantiomer 75 and 76 via Hantzsch reaction. 57890 | RSC Adv., 2015, 5, 57883-57905 This journal is Scheme 26 Multicomponent synthesis of polyhydroxyl thiomidazoles from aldoses and ketoses.Fig. 6 Synthesised polyhydroxy imidazoles using different aldoses and ketoses. Scheme 27 Multicomponent synthesis of annulated pyrroles in choline chloride : urea (CC/U). Scheme 28 Multicomponent synthesis of sugar derived triaozolodiazepine. 57894 | RSC Adv., 2015, 5, 57883-57905 This journal is Scheme 36 Total synthesis of (À) muramycin D 2 Ugi based multicomponent reaction. Scheme 37 Ugi-4CR synthesis of trypsin-CMC and trypsin-ALG conjugate. This journal is Scheme 41 Three component sequential synthesis of glyco-hydantoin conjugates. Scheme 42 Mechanism showing the favourable O-N acyl migration and slow intramolecular aza-Micheal step. Scheme 43 Conversion of glyco-hydantoin conjugates into sugar-pseudopeptide. Scheme 44 Synthesis of sugar lactone fused spiropyrrolizidine oxindole. 57902 | RSC Adv., 2015, 5, 57883-57905 This journal is

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