A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri

Anti-Inflammatory Properties of Extracts, Fractions and Lignans Isolated fromPhyllanthus amarus

“…Lignans are an important class of active plant natural-occurring compounds known to possess a variety of effects, acting as antiinflammatory [10], antitumoural, antimitotic, antiviral and antiatherosclerotic agents [11]. Phytochemical studies have revealed Anti-Inflammatory Properties of Extracts, Fractions and Lignans Isolated from Phyllanthus amarus the existence of lignans, such as hypophyllanthin, phyllanthin and nirtetralin in P. niruri [12] and phyltetralin nirtetralin, niranthin, hypophyllantin, and phyllantin, in P. amarus [9] (see the structures in Fig. 1).…”

Synthesis and Characterization of Some Substituted 3, 4-dihydronaphthalene Derivatives through Different Enaminones as Potent Cytotoxic Agents

“…Due to the undesirable side eff ects of chemotherapeutic agents and emergence of drug resistance, there is an urgent need for developing new chemotherapeutic agents with more potent anti-tumor activity and high therapeutic index [ 2 ] . Literature survey has investigated the worthy of tetrahydronaphthalene derivatives as anticancer [ 3 -6 ] , antibacterial [ 7 , 8 ] , moluscidal [ 9 ] , hypotensive [ 10 ] , anti-infl ammatory [ 11 ] and anti-HIV [ 12 ] agents. Moreover, some of the tetrahydronaphthalene derivatives were used in the treatment of Al zheimer disease [ 13 ] , anxiety and depression [ 14 , 15 ] .…”

Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study

“…It has been traditionally used as expectorant, anti-febrile, anti-diarrhoea, a diuretic and a remedy for colic and kidney problems [1]. The plant contains a series of lignans [2][3][4][5][6][7][8], alkaloids [9][10][11], terpenoids [12] and tannins [13,14], which have been reported to be hepatoprotective [15], anti-inflammatory [16] and endothelin-1 antagonist [17]. They also inhibited HIV reverse transcriptase [18][19][20], viral hepatitis [21] and increased vinblastine cytotoxicity towards multidrugresistant cancer cells [22].…”