A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A y mice

Wang, Kai; Li, Bao; Ma, Ke; Zhang, Jinjin; Chen, Baosong; Han, Junjie; Ren, Jinwei; Hy, Luo; Liu, Hongwei

doi:10.1016/j.ejmech.2016.11.015

Cited by 96 publications

(65 citation statements)

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“…The inhibition of HMG-CoA reductase effectively lowers the level of cholesterol in humans by the activation of sterol regulatory element-binding protein-2, which upregulates the HMG-CoA reductase and LDL receptors that lead to the reduction of cholesterol levels [ 25 ], since there are many drugs at clinical level that lower cholesterol level targeted on the HMG-CoA reductase enzyme inhibition [ 26 , 27 ]. Thus, potent inhibitors of this enzyme can play a key role in the management of hyperlipidemia worldwide [ 26 – 29 ]. The present study showed that both bark extracts of true cinnamon inhibited the HMG-CoA reductase enzyme in a dose-dependent manner (ethanol and DCM : M bark extracts IC 50 : 153.07 ± 8.38 and 277.13 ± 32.18 μ g/mL, resp.).…”

Section: Discussionmentioning

confidence: 99%

Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro

Abeysekera

Arachchige

Ratnasooriya

2017

Evidence-Based Complementary and Alternative Medicine

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Ethanol (95%) and dichloromethane : methanol (1 : 1) bark extracts of authenticated Ceylon cinnamon were investigated for range of antilipidemic activities (ALA): HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities and bile acids binding in vitro. Individual compounds in bark extracts were also evaluated. Bark extracts showed ALA in all the assays studied. The IC50 (μg/mL) values ranged within 153.07 ± 8.38–277.13 ± 32.18, 297.57 ± 11.78–301.09 ± 4.05, 30.61 ± 0.79–34.05 ± 0.41, and 231.96 ± 9.22–478.89 ± 9.27, respectively, for HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities. The bile acids binding (3 mg/mL) for taurocholate, glycodeoxycholate, and chenodeoxycholate ranged within 19.74 ± 0.31–20.22 ± 0.31, 21.97 ± 2.21–26.97 ± 1.61, and 16.11 ± 1.42–19.11 ± 1.52%, respectively. The observed ALA were moderate compared to the reference drugs studied. Individual compounds in bark extracts ranged within 2.14 ± 0.28–101.91 ± 3.61 and 0.42 ± 0.03–49.12 ± 1.89 mg/g of extract. Cinnamaldehyde and gallic acid were the highest and the lowest among the tested compounds. The ethanol extract had highest quantity of individual compounds and ALA investigated. Properties observed indicate usefulness of Ceylon cinnamon bark in managing hyperlipidemia and obesity worldwide. Further, this study provides scientific evidence for the traditional claim that Ceylon cinnamon has antilipidemic activities.

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Section: Discussionmentioning

confidence: 99%

Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro

Abeysekera

Arachchige

Ratnasooriya

2017

Evidence-Based Complementary and Alternative Medicine

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“…Levels of serum glucose, total cholesterol (TC, T-CHO), triglycerides (TG), free fatty acids (FFA), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin A1C (HbA1C) and insulin were measured as previously described (Wang et al, 2017). The insulin sensitivity index (ISI) was calculated from the values of fasting blood glucose (FBG, FBPase activity assay FBPase activity was determined spectrophotometrically by a method described in an earlier report (el-Maghrabi et al, 1993).…”

Section: Author Contributionsmentioning

confidence: 99%

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Wang¹,

et al. 2019

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“…Ganomycin as obtained from Ganoderma leucocontextum is another promising inhibitor . The terpenoid has revealed promising activity both in in vitro and in vivo studies.…”

Section: Inhibitory Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A y mice

Cited by 96 publications

References 40 publications

Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro

Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Natural Monoterpenes: Much More than Only a Scent

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