A novel composite of micelles and hydrogel for improving skin delivery of hydrocortisone and application in atopic dermatitis therapy

Yuan, Liping; Pan, Meng; Lei, Minyi; Zhou, Xinran; Hu, Danrong; Liu, Qingya; Chen, Yu; Li, Wei; Qian, Zhiyong

doi:10.1016/j.apmt.2020.100593

Cited by 14 publications

(15 citation statements)

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“…In another study, significant dermal delivery of hydrocortisone from novel composites constituted of micelles and hydrogel was reported. An enhanced permeation rate with cumulative quantities of hydrocortisone transported was many folds higher compared to hydrocortisone cream [ 117 ]. Thus, incorporating a particulate carrier loaded with the drug within the hydrogel matrix can be considered as a feasible and effective strategy for transdermal therapy.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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“…Higher permeation rate compared to conventional cream [79] Adenosylcobalamin (B 12 derivative) L--phosphatidylcholine and cholesterol liposomes incorporated in a carbopol 940 hydrogel with triethylamine, hydroxyethylcellulose, disodium EDTA, methylparaben, PEG-60 hydrogenated castor oil, glycerin, and ethyl alcohol Reduced skin inflammation; Lower IgE [81] Glycyrrhizic acid Transfersomes incorporated in a hydrogel containing methyl paraben, propyl paraben, sodium meta bisulfite, carbopol 940, sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100 M.…”

Section: Hydrogels For Bioactive Compounds' Deliverymentioning

confidence: 99%

“…Hydrocortisone was also incorporated by Yuan and colleagues into monomethyl poly(ethylene glycol)‐poly(ε‐caprolactone) micelles ( Figure ), to be further embedded in a Carbopol hydrogel. [ 79 ] This new system permeated rat skin at a higher rate and higher cumulative amount when comparing to hydrocortisone conventional cream, also reducing skin inflammation and irritation in an AD‐like mouse model.…”

Section: Hydrogels For Atopic Dermatitismentioning

confidence: 99%

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Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

Barbosa

Torres

Lima

2021

Advanced Therapeutics

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Atopic dermatitis (AD) is an inflammatory skin disease with a high worldwide prevalence. AD is characterized by fluctuating and recurrent eczematous lesions and intense itch, being associated with high physical and psychological impact leading to disturbed sleep quality, anxiety, and depression. Most of the patients have mild to moderate forms of atopic dermatitis and topical therapies (emollients, corticosteroids, calcineurin, and phosphodiesterase 4 inhibitors) are the mainstay of therapy for these patients. Hydrogels are explored in the field of cutaneous application and have proven to be a good solution as a topical vehicle for atopic dermatitis, due to their high water content, improved drug delivery, responsiveness to stimuli and versatility in terms of preparation and drug-loading, representing a good alternative to regular ointments or creams. This review highlights some of the atopic dermatitis characteristics and the use of hydrogels in the management of this disease. An outline of hydrogels as drug delivery systems for bioactive compounds is discussed, as well as their major advantages and drawbacks when compared to other galenic forms, and also an overview of clinical trials and patents engaged in the past 20 years.

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“…HC (the steroid) was selected due to its wide multifunctional therapeutic application (including acute inflammation, asthma and skin conditions [ 49 , 50 ]). Whilst transdermal delivery of HC using cream, adhesive patches [ 51 ], micro/nano-encapsulations [ 52 , 53 ] and phonophoresis [ 54 ] have been previously studied, application of HC using MSts is a new approach (although other steroids have been reported to be delivered via MN [ 55 ]), which could greatly enhance the permeability of this drug. In this study, the in vitro permeation of both HC (pKa 13.8) and HC-HS (pKa 5.64) have been performed to compare the efficiency of using MSt in delivery of both formulations.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of Drug Delivery Efficacy Using Microstructure-Assisted Application of a Range of APIs

et al. 2020

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Polymer-based solid microstructures (MSts) have the potential to significantly increase the quantity and range of drugs that can be administered across the skin. MSt arrays are used to demonstrate their capacity to bypass the skin barrier and enhance permeability by creating microchannels through the stratum corneum, in a minimally invasive manner. This study is designed to demonstrate the ability of MSts to exceed the current boundaries for transdermal delivery of compounds with different molecular weights, partition coefficients, acid dissociation constants, melting points, and water solubilities. In vitro permeation of a range of selected molecules, including acetyl salicylic acid (aspirin), galantamine, selegiline hydrochloride (Sel-HCl), insulin, caffeine, hydrocortisone (HC), hydrocortisone 21-hemisuccinate sodium salt (HC-HS) and bovine serum albumin (BSA) has been studied across excised porcine skin with and without poke and patch application of MSts. Permeation of the molecules was monitored using Franz diffusion cells over 24 h. MSts significantly increased the permeation of all selected molecules up to 40 times, compared to topical applications of the molecules without MSts. The greatest increase in permeation was observed for caffeine with 70 ± 8% permeation and the lowest enhancement was observed for HC with a 2.4 ± 1.3% increase in permeation. The highest obtained flux was BSA (8133 ± 1365 μg/cm2/h) and the lowest flux observed for HC (11 ± 4 μg/cm2/h). BSA and HC also showed the highest (16,275 ± 3078 μg) and the lowest (73 ± 47 μg) permeation amount after 24 h respectively. MSt-treated skin exhibits greatly increased permeation. The molecule parameters (size, acid dissociation constant, partition coefficient and solubility)—traditional hurdles associated with passive diffusion through intact skin—are overcome using MSt skin treatment.

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A novel composite of micelles and hydrogel for improving skin delivery of hydrocortisone and application in atopic dermatitis therapy

Cited by 14 publications

References 58 publications

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

Characterisation of Drug Delivery Efficacy Using Microstructure-Assisted Application of a Range of APIs

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