A novel construction of quino-fused tropone skeleton: first synthesis of 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives

Synthesis of Substituted Tropones and Advancement for the Construction of Structurally Significant Skeletons

“…A good yield of 12H-benzo [4,5]cyclohepta[1,2-b]quinolin-12-one 16 a was obtained from one-pot synthesis by using PPA (polyphosphoric acid) as cyclizing agent at 150 °C after 4 h (Scheme 3) (Table 1) via intramolecular Friedel-Crafts acylation of 15 a. [74] By using this synthetic methodology, a wide variety of desired cyclized products were obtained in good yields (65 %-80 %).…”

A Novel Synthesis of 2‐Ferrocenoyl‐Substituted Iodobenzofurans

“…To the best of our knowledge, the construction of this type of hybrid molecules still remained unknown. Accordingly, with this context and in continuation of our studies on the synthesis of highly interesting types of hybrid heterocycles , we would like to report, herein, the first synthesis of a series of meaningful 2‐ferrocenoyl‐based iodobenzofurans.…”

A Simple and Facile Synthesis of 4‐Phenylquinoline‐fused Pyrrolidin‐2‐ones

“…In the last few years, our research group has gained substantial ability in the application of ethyl 2-(halomethyl)quinoline-3-carboxylates [22][23][24] as the valuable building blocks to reveal the synthetic potential of the platforms in accessing important quinoline scaffold derivatives [25][26][27][28][29]. Building on these evolving expertise and considering the aforementioned findings, we hereby would like to report a very simple and facile synthesis of a series of such 4-phenylquinoline-fused pyrrolidin-2-one derivatives, namely, 9-phenyl-2-substituted-2,3-dihydro-1H-pyrrolo [3,4-b]quinolin-1-ones (3) as shown in Scheme 1c.…”