A novel copper-based metal-organic framework as a peroxidase-mimicking enzyme and its glucose chemiluminescence sensing application

Metal organic framework-based antibacterial agents and their underlying mechanisms

“…However, considering the sensitive nature of enzymes, it is necessary to find some substitutes that are more stable, such as the commonly reported artificial enzymes CuO and MoS 2 . 191 Alternatively, due to the distinct structural characteristics and tunable compositions of MOFs, they have also played important roles in this area, 192,193 such as the Cu-based, Zn-based and metalloporphyrin-based MOFs. 194 MOFs possess separate active sites (such as Zn 2+ and Cu 2+ metal nodes or organic linker metalloporphyrins) and open channels, which prevent the gathering or dipolymer of the active compounds and provide more open active sites and space for the zymolyte and products to diffuse, 191,195 and thus exhibit high catalytic activity and have attracted significant attention.…”

Chemiluminescent magnetic nanoparticles with good catalytic activity and rapid separation capability and sensitive sensing for H2O2

“…Previously, it was also reported that CuFe 2 O 4 with peroxidase-like catalytic activity could catalyze the decomposition of H 2 O 2 to generate OH•, which was beneficial to enhance the efficiency of CL reactions [ 30 ]. Besides, Cu 2+ and Cu 0 was able to produce OH• indirectly in the presence of H 2 O 2 [ 31 – 33 ]. It was speculated that CuFe 2 O 4 , Cu 2+ , and Cu 0 may facilitate the generation of O 2 • − and OH• during ABEI CL reaction, leading to high CL efficiency.…”

Alkaline-Stable Peroxidase Mimics Based on Biological Metal–Organic Frameworks for Recyclable Scavenging of Hydrogen Peroxide and Detecting Glucose in Apple Fruits

“…Due to these merits, they have drawn much attention for their great potential application in medicine, food processing, environmental analysis, and biotechnology. − Among the enzyme mimics, peroxidase mimics have received the most attention due to their highly catalytic properties, low toxicity, and broad applicability. − Small molecules, metal oxides, metallic oxide nanoparticles (NPs), carbon materials, metal–organic frameworks (MOFs), etc. have been proved to have a unique peroxidase-like catalytic activity. ,− However, most of the peroxidase mimics have been restricted for further bioanalysis due to the limited reaction environment, which must be strictly controlled in a pH range of about 3–4. − Given that the pH value of most biological systems is often close to neutral (5–7.4), it is highly desirable to develop peroxidase mimics capable of competent catalytic activity at a near-neutral pH value.…”

“…MOFs, which are supermolecular or three-dimensional extended periodic network structures, can be diversely tailored by the judicious selection of metal ion and organic ligand building blocks to achieve required properties. , They provide a coordination environment similar to that of natural enzymes owing to their adjustable cavities and channels, making them have potential applications in drug delivery, thermal insulation, separation, and filtration. − MOFs have been recently reported to show a high peroxidase-like catalytic activity in the pH range of 3–10 and have been employed as colorimetric biosensors, thereby further expanding the scope of analytical applications. ,− The most pervasive biosensors take advantage of the Cu-based MOFs, which undergo the Fenton-like reaction in the presence of hydrogen peroxide. , H 2 O 2 can be activated by Cu 2+ to generate active oxygen species, such as • OH, • OOH, and O 2 •– , in a copper-catalyzed Fenton-like system . The hydroxyl radical ( • OH) generated from the activation of H 2 O 2 has a strong oxidation potential; thus, various activation schemes have been used for degrading organic contaminants into harmless compounds, low-molecular-weight organic acids, inorganic salts, and water. , An increasing number of studies have demonstrated that the Cu-based MOFs with appropriate ligands may significantly improve the catalytic activities of Cu 2+ and increase the effectiveness in decomposing organic compounds, as well as scavenging H 2 O 2 . , In addition, with the catalytic system of Cu-MOFs and H 2 O 2 , the colorless peroxidase substrate 3,3′,5,5′-tetramethyl-benzidine (TMB) and 2,2′-azino-bis­(3-ethylbenzothiazoline-6-sulfonate) (ABTS) are oxidized to blue oxTMB and green oxABTS, respectively. , The color-changing process can be observed by naked eyes, enabling such MOFs to be used as eye-probes of H 2 O 2 . Thus, the system based on the Fenton-like reaction and oxidation of the peroxidase substrate provides a convenient colorimetric signal transition strategy for constructing bioanalytical methods.…”