A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer

Abstract

Purpose: Cuproptosis, a form of copper-induced cell death, can be a promising therapeutic target for refractory cancers. Hence, we conducted this research to explore the association between cuproptosis and prognosis in cervical cancer (CC).Methods: For constructing a prognostic signature based on cuproptosis-related genes from TCGA database, the least absolute shrinkage and selection operator Cox regression was utilized. The GSE44001 cohort was utilized for validation.Results: A total of nine cuproptosis-related genes showed distinct expression in CC and normal samples in TCGA-GTEx cohort. Two risk groups were identified based on a seven-gene signature. A significant decrease in overall survival was observed in the high-risk group (p < 0.001). The risk score (HR = 2.77, 95% CI = 1.58–4.86) was an autocephalous predictor with a better predictive ability than the clinical stage. Functional analysis indicated that immune activities were suppressed more in the high-risk group than in the low-risk group. A total of 11 candidate compounds targeting the signature were identified.Conclusion: A total of seven cuproptosis-related gene signatures were constructed to predict prognosis and propose a new therapeutic target for patients with CC.

A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values

“…Abnormal accumulation of intracellular copper induces a new mode of cell death, copper drooping ( Kahlson and Dixon, 2022 ). The copper homeostasis has been associated with the development and prognosis of patients with various tumors ( Feng et al, 2022 ; Huang et al, 2022 ; Lei et al, 2022 ; Li et al, 2022 ; Wang et al, 2022 ). As a copper death-related gene, LIPT1 is required for lipoylation and activation of 2-ketoacid dehydrogenases in humans ( Tort et al, 2014 ).…”

Prognostic prediction of head and neck squamous cell carcinoma: Construction of cuproptosis‐related long non‐codingRNAsignature

“…To the best of our knowledge, researchers have recently started focusing on the relationship between cuproptosis and several cancers, and constructed some different cuproptosis‐related gene signatures for predicting prognosis in cervical cancer, 29 pancreatic cancer, 30 Clear Cell Renal Cell Carcinoma 31 . LncRNAs are potential biomarkers that can be used to treat numerous diseases, especially tumors 8,9 .…”

Development and validation of a cuproptosis-associated prognostic model for diffuse large B-cell lymphoma

“…Not surprisingly, the oxidative phosphorylation inhibitor Gboxin analog was found to have a strong proliferation inhibitory and cell cycle blocking effect on DLBCL with specific selectivity for it ( 34 ). Several recent studies have revealed the potential role of CRGs in the prognosis of cancers, such as kidney cancer ( 35 – 42 ), hepatocellular carcinoma ( 43 – 47 ), lung cancer ( 48 – 53 ), head and neck squamous cell carcinoma ( 53 – 60 ), glioma ( 61 – 66 ), breast cancer ( 67 – 70 ), endometrial carcinoma ( 71 , 72 ), melanoma ( 73 – 75 ), pancreatic cancer ( 76 , 77 ), colorectal cancer ( 78 – 81 ) and so on. However, no reports describe any effects of the cuproptosis regulatory mechanism on DLBCL.…”