A novel cytotoxic ternary copper(II) complex of 1,10-phenanthroline and l-threonine with DNA nuclease activity

Zhang, Shouchun; Zhu, Yangguang; Tu, Chao; Wei, Haiying; Yang, Zhen; Lin, Liping; Ding, Jian; Zhang, Junfeng; Guo, Zijian

doi:10.1016/j.jinorgbio.2004.09.014

Cited by 236 publications

(79 citation statements)

References 40 publications

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“…The complexes are in good agreement with the previously reported square pyramidal geometry of the complexes [20][21][22] .…”

Section: Electronic Absorption Spectrasupporting

confidence: 91%

“…Very recently, mixed ligand copper(II) complexes have been found to exhibit prominent anticancer activity by inducing apoptosis and, interestingly, they are found to strongly bind and cleave DNA [35][36][37] . In general, redoxactive agents that damage DNA in vitro are thought to exhibit apoptotic activities in live cells by inducing oxidative stress and/or DNA damage [38] .…”

Section: Anticancer Activitymentioning

confidence: 99%

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Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Ezhilarasan¹,

Krishnan²,

Arumugham³

2017

Int. J. Curr. Res. Chem. Pharm. Sci

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Ternary copper(II) complexes [Cu(phen)(L-met)EA)] 1 & [Cu(Bpy)(L-met)EA] 2 ( phen = 1,10-phenanthroline Bpy = bipyridyl, LMethionine and EA= Ethylamine), have been synthesized and characterized by CHN analysis, molar conductance, electronic absorption, IR and EPR spectral studies. They have been tested for their in vitro DNA binding activities by the spectroscopic methods such as UV-Visible, Cyclic volumetric and viscosity measurement. Further, complexes 1 and 2 displayed significant cytotoxicity when examined in-vitro on a panel of cancerous cell line -human liver cancer cell line -HepG-2 cells (IC50= 40.82 and 29.74 μg/ml). Further complexes 1 & 2 were tested for their antimicrobial activities and it was found to have good antimicrobial activities.

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“…The complexes are in good agreement with the previously reported square pyramidal geometry of the complexes [20][21][22] .…”

Section: Electronic Absorption Spectrasupporting

confidence: 91%

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Ezhilarasan¹,

Krishnan²,

Arumugham³

2017

Int. J. Curr. Res. Chem. Pharm. Sci

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“…Cu(II) complexes containing heterocyclic bases have been extensively explored in virtue of their strong interactions with DNA and cytotoxic activity [7][8][9]. They can act as chemical nucleases [10,11] and their cytotoxicity has been proposed to be caused by their ability to bind and cleave DNA that leads to cell cycle arrest and apoptosis or generation of reactive oxygen species (ROS) that in turn leads to cell death [12]. Literature has shown that Cu(II)-based complexes exhibit antineoplastic potency towards human ovarian carcinoma (CH1), murine leukemia (L1210), and various cervicouterine carcinomas which is comparable to or even higher than that of cisplatin [13,14].…”

Section: Introductionmentioning

confidence: 99%

Cu(II) Complexes of Isoniazid Schiff Bases: DNA/BSA Binding and Cytotoxicity Studies on A549 Cell Line

Pulipaka

Singh

Prajapati

et al. 2014

Advances in Chemistry

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A series of isonicotinoyl hydrazones have been synthesized via template method and were complexed to Cu(II). The ligands are coordinated to Cu(II) ion through the enolic oxygen and azomethine nitrogen resulting in a square planar geometry. The CT-DNA and bovine serum albumin binding propensities of the compounds were determined spectrophotometrically, the results of which indicate good binding propensity of complexes to DNA and BSA with high binding constant values. Furthermore, the compounds have been investigated for their cytotoxicities on A549 human lung cancer cell. Also the mode of cell death was examined employing various staining techniques and was found to be apoptotic.

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“…Recently there are several reports of copper(II) complexes showing efficient chemical nuclease activity [12][13][14][15]. Recent reports have also shown that amino acid/peptide based copper(II) complexes show efficient DNA cleavage activity by oxidative and hydrolytic pathways [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

DNA binding and oxidative cleavage activity of ternary (l-proline)copper(II) complexes of heterocyclic bases

2007

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A novel cytotoxic ternary copper(II) complex of 1,10-phenanthroline and l-threonine with DNA nuclease activity

Cited by 236 publications

References 40 publications

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Cu(II) Complexes of Isoniazid Schiff Bases: DNA/BSA Binding and Cytotoxicity Studies on A549 Cell Line

DNA binding and oxidative cleavage activity of ternary (l-proline)copper(II) complexes of heterocyclic bases

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