A novel design of printable tunable stiffness metamaterial for bone healing

Hashemi, Mohammad Saber; McCrary, Aaron; Kraus, Karl H.; Sheidaei, Azadeh

doi:10.1016/j.jmbbm.2021.104345

Cited by 18 publications

(13 citation statements)

References 29 publications

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“…The stress and strain at which the topological transition takes place, as well as the magnitude of the topology-induced stiffening can be tuned over almost two orders of magnitude by the unit cell design, as shown by a comprehensive numerical study of the design space. This is a significant improvement compared to other recent strain-stiffening metamaterials with a maximum modulus ratio of about 10 [35, 36], respectively 50 [37]. It is important to emphasize that the fundamental principle of the strain-stiffening effect in those studies is rather based on compaction, which is a well studied phenomenon in cellular solids [38], and works exclusively in compression.…”

Section: Discussionmentioning

confidence: 93%

Deformation-induced topological transitions in mechanical metamaterials and their application to tunable non-linear stiffening

Wagner,

Schwarz,

Huber

et al. 2021

Preprint

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Mechanical metamaterials are periodic lattice structures with complex unit cell architectures that can achieve extraordinary mechanical properties beyond the capability of bulk materials. Here, we propose a new class of mechanical metamaterials whose mechanical properties rely on deformation induced topological transitions by formation of internal self-contact between nodes. The universal nature of the principle presented is demonstrated by designing metamaterials undergoing topological transitions under tension, compression, shear and torsion. In particular, we show that by frustration of soft inextensional deformation modes, large highly non-linear stiffening effects can be generated in these metamaterials. The topology-induced stiffening can be exploited to design materials that mimic the complex mechanical response of biological tissue, such as human intervertebral discs.

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Section: Discussionmentioning

confidence: 93%

Deformation-induced topological transitions in mechanical metamaterials and their application to tunable non-linear stiffening

Wagner,

Schwarz,

Huber

et al. 2021

Preprint

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“…For instance, the stress shielding issue mostly seen in orthopedic bone implants can be solved by lattice and shell-type architecture in bone scaffolds, in which the varied topology of nodal connections has great potential to control the relative rigidity of the metamaterial [218]. Three-dimensional printing technology, along with multi-objective genetic algorithm (GA) optimization with the finite element (FE) simulation, can be used to produce an optimum force-displacement response in designing printable tunable stiffness metamaterial for bone healing [219]. Mechanical 3D metamaterial with a porous structure is among the best materials for bone implants, with a graded Poisson's ratio distribution to optimize stress and micromotion distributions.…”

Section: Metasurfaces and Metamaterialsmentioning

confidence: 99%

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Zhou

Attarilar

et al. 2021

Coatings

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Due to the growing aging population of the world, and as a result of the increasing need for dental implants and prostheses, the use of titanium and its alloys as implant materials has spread rapidly. Although titanium and its alloys are considered the best metallic materials for biomedical applications, the need for innovative technologies is necessary due to the sensitivity of medical applications and to eliminate any potentially harmful reactions, enhancing the implant-to-bone integration and preventing infection. In this regard, the implant’s surface as the substrate for any reaction is of crucial importance, and it is accurately addressed in this review paper. For constructing this review paper, an internet search was performed on the web of science with these keywords: surface modification techniques, titanium implant, biomedical applications, surface functionalization, etc. Numerous recent papers about titanium and its alloys were selected and reviewed, except for the section on forthcoming modern implants, in which extended research was performed. This review paper aimed to briefly introduce the necessary surface characteristics for biomedical applications and the numerous surface treatment techniques. Specific emphasis was given to micro/nano-structured topographies, biocompatibility, osteogenesis, and bactericidal effects. Additionally, gradient, multi-scale, and hierarchical surfaces with multifunctional properties were discussed. Finally, special attention was paid to modern implants and forthcoming surface modification strategies such as four-dimensional printing, metamaterials, and metasurfaces. This review paper, including traditional and novel surface modification strategies, will pave the way toward designing the next generation of more efficient implants.

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“…Besides the structures mentioned above, some new smart structures have also been designed and investigated in the literature. For example, Hashemi et al (2021) designed a new structure that can be treated as auxetic structure to solve the problems such as the stress shielding and bone nonunion in the healing of fractured bones ( Figure 3 ). The structures designed possess a tunable stiffness, and the results showed that the novel bone rods allow for the broken bones to move in a controlled fashion along the longitudinal axis.…”

Section: Review On the Application Of The Metamaterials In The Bone Scaffoldmentioning

confidence: 99%

“… An example using the smart structure to design the bone replacement (adapted from Hashemi et al, 2021 ). …”

Section: Review On the Application Of The Metamaterials In The Bone Scaffoldmentioning

confidence: 99%

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

Huo

Lü

Meng

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, bone tissue engineering has emerged as a promising solution for large bone defects. Additionally, the emergence and development of the smart metamaterial, the advanced optimization algorithm, the advanced manufacturing technique, etc. have largely changed the way how the bone scaffold is designed, manufactured and assessed. Therefore, the aim of the present study was to give an up-to-date review on the design, manufacturing and assessment of the bone scaffold for large bone defects. The following parts are thoroughly reviewed: 1) the design of the microstructure of the bone scaffold, 2) the application of the metamaterial in the design of bone scaffold, 3) the optimization of the microstructure of the bone scaffold, 4) the advanced manufacturing of the bone scaffold, 5) the techniques for assessing the performance of bone scaffolds.

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A novel design of printable tunable stiffness metamaterial for bone healing

Cited by 18 publications

References 29 publications

Deformation-induced topological transitions in mechanical metamaterials and their application to tunable non-linear stiffening

Deformation-induced topological transitions in mechanical metamaterials and their application to tunable non-linear stiffening

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

A Critical Review on the Design, Manufacturing and Assessment of the Bone Scaffold for Large Bone Defects

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