A novel device for resistance-free biomechanical testing of the metaphysis of long bones

Mackert, Gina A.; Hirche, Christoph; Harhaus, H; Kotsougiani, Dimitra; Hoener, Bernd; Kneser, Ulrich; Harhaus, Leila

doi:10.1186/1471-2474-15-245

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…The newly formed tibial callus was analyzed for the biomechanical parameters stiffness (S), yield load (yL), maximum load (Fmax) and failure load (fL) through a 3-point bending/breaking test using a ZWICK-testing machine (ZWICK-testing machine type Z020/TND; ZWICK-/Roell, Ulm, Germany) according to an established protocol [ 24 , 25 ]. Each tibia was individually placed onto a friction-minimizing mobile, ball-mounted platform [ 24 ]. The stamp was aligned onto the ventral tibia metaphysis to apply force (Newton) precisely onto the fracture site.…”

Section: Methodsmentioning

confidence: 99%

Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model

et al. 2017

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PurposeAs result of the current demographic changes, osteoporosis and osteoporotic fractures are becoming an increasing social and economic burden. In this experimental study, extracorporeal shock wave therapy (ESWT), was evaluated as a treatment option for the improvement of osteoporotic fracture healing.MethodsA well-established fracture model in the metaphyseal tibia in the osteoporotic rat was used. 132 animals were divided into 11 groups, with 12 animals each, consisting of one sham-operated group and 10 ovariectomized (osteoporotic) groups, of which 9 received ESWT treatment. Different energy flux intensities (0.15 mJ/mm2, 0.35 mJ/mm2, or 0.55 mJ/mm2) as well as different numbers of ESWT applications (once, three times, or five times throughout the 35-day healing period) were applied to the osteoporotic fractures. Fracture healing was investigated quantitatively and qualitatively using micro-CT imaging, quantitative real-time polymerase chain reaction (qRT-PCR) analysis, histomorphometric analysis and biomechanical analysis.ResultsThe results of this study show a qualitative and quantitative improvement in the osteoporotic fracture healing under low-energy (energy flux intensity: 0,15 mJ/mm2) ESWT and with fewer treatment applications per healing period.ConclusionIn conclusion, low-energy ESWT seems to exhibit a beneficial effect on the healing of osteoporotic fractures, leading to improved biomechanical properties, enhanced callus-quantity and -quality, and an increase in the expression of bone specific transcription factors. The results suggest that low-energy ESWT, as main treatment or as adjunctive treatment in addition to a surgical intervention, may prove to be an effective, simple to use, and cost-efficient option for the qualitative and quantitative improvement of osteoporotic fracture healing.

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Section: Methodsmentioning

confidence: 99%

Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model

et al. 2017

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“…11 Three-point bending tests are the most commonly used mechanical tests to characterize bone material and biomechanical properties of long bones. 12,13 Standardization of three-point bending tests on the methaphysis of long bones without bone defects has been reported, 3,7,14 however, there there are no guidelines for parameters such as span and bone defect positioning. 12,13,14 Adequate stability of the bone between the supports during the test must is determined by the length of metaphysis region, which constitutes a limitation for the span distance.…”

Section: Introductionmentioning

confidence: 99%

“…A standardized protocol is needed to allow comparisons of data from different sources and to ensure that biomechanical properties are obtained at the targed area of the bone defect. 3,7,14 Three-point bending tests provide structural information about the whole bone, such as stiffness and strength. However, they cannot provide local information, such as stress distribution.…”

Section: Introductionmentioning

confidence: 99%

Influence of bone defect position and span in 3-point bending tests: experimental and finite element analysis

et al. 2021

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“…But it cannot be applied to evaluate the biomechanical properties under external axial force. Mackert et al (2014) developed a mobile, ball-mounted platform device used in the three-point bending/breaking test, which was able to efficiently eliminate the influence of friction in terms of stiffness and yield load. However, a ZWICK-testing machine was needed to apply force, and only a three-point bending/breaking test could be carried out.…”

Section: Introductionmentioning

confidence: 99%

A novel testing system for biomechanical evaluation of the bone or bone fixator

Zhang

Guo

Liang

et al. 2018

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Purpose Biomechanical properties of bones and fixators are important. The aim of this study was to develop a new device to simulate the real mechanical environment and to evaluate biomechanical properties of the bone with a fixation device, including the static force and the fatigue characters. Design/methodology/approach In this paper, the device is mainly composed of three parts: pull-pressure transmission system, bending force applying system and torsion applying system, which can successfully simulate the pre-introduced pull-pressure force, bending force and torsion force, respectively. To prove the feasibility of the design, theoretical analysis is used. It is concluded from the simulated result that this scheme of design can successfully satisfy the request of the evaluation. Findings Finally, on the basis of the force sensor calibration, the static force experiment and fatigue experiment are carried out using the tibia of the sheep as the specimen. It is concluded from the result that the relationship between the micro displacement and the applied axial force is nearly linear. Under the condition of 1 Hz in frequency, 500 N in loading force and 18,000 reciprocating cycles, the bone fixator can still be in good condition, which proves the feasibility of the design. Originality/value Biomechanical properties of bones and fixators are studied by researchers. However, few simulate a real force environment and combine forces in different directions. So a novel system is designed and fabricated to evaluate the biomechanical properties of the bones and fixators. Results of the experiments show that this new system is reliable and stable, which can support the biomechanical study and clinical treatment.

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A novel device for resistance-free biomechanical testing of the metaphysis of long bones

Cited by 4 publications

References 26 publications

Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model

Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model

Influence of bone defect position and span in 3-point bending tests: experimental and finite element analysis

A novel testing system for biomechanical evaluation of the bone or bone fixator

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