A novel Diels–Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death

Shu, Yuhan; Yuan, Huahua; Xu, Mengting; Hong, Yeting; Gao, Chunfang; Wu, Zhipan; Han, Haote; Sun, Xin; Gao, Ruilan; Yang, Sifu; Li, Shouxin; Tian, Jingkui

doi:10.1038/s41401-020-0492-5

Cited by 27 publications

(25 citation statements)

References 43 publications

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“…Grape stem Fig. 3 Minimum inhibitory concentration values (MIC) of irradiated grape leaves, grape seeds and mulberry leaves at 5.0 kGy against some food pathogenic bacteria extracts reduced cancer cell (Caco-2, MCF-7, and MDA-MB-231) proliferation, triggering death through apoptosis via mitochondrial potential alteration and a decrease in the antioxidant enzyme TrxR1, resulting in an increase in cellular lethality [76].…”

Section: Anticancer Activitymentioning

confidence: 99%

Biological activities of Egyptian grape and mulberry by-products and their potential use as natural sources of food additives and nutraceuticals foods

Abdel-Khalek

Mattar

2022

Food Measure

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Interest in the biological role of bioactive compounds present in plant by-products has increased over the last few years. This study aimed to investigate the nutritive value and biological activities of Egyptian Grape leaves (GL), Grape seeds (GS) and Mulberry leaves (ML), as well as investigate the impact of γ-irradiation for improving the utilization of these plant byproducts. The dose level 5.0 kGy showed highest the content of crude protein (24.42, 19.41 and 13.50 mg/100 g), as well as crude fiber (34.26 and 21.18 mg/100 g) for ML, GL and GS, respectively. Mulberry leaves has a highest content of protein and fiber at dose 5.0 kGy compared with GL and GS. The highest total phenolic content was found in GS (9.75 mg/g DW), followed by GL (7.32 mg/g DW) and the lowest in ML (5.97 mg/g DW). While ML had a higher total flavonoids content (5.61 mg/g DW) than GS (4.88 mg/g DW) and GL (2.86 mg/g DW). Total phenolic and flavonoid contents were significantly increased at 5.0 kGy. The highest level (83.25% and 80.24%) of scavenging activity (DPPH %) and inhibition activity of HCT 116 cells was recorded at 5.0 kGy by GS. All extracts irradiated at 5.0 kGy exhibited varying degrees of antibacterial activity against (Gram+ve and Gram-ve), the GS followed by GL then ML showed strong antibacterial activity with a diameter of inhibition zone of 26.2, 24.5 and 19.7 mm, against L. monocytoganes, respectively and 24.4, 21.4 and 17.2 against S. typhimurium, respectively. This study suggests that γ-irradiation is an effective technique to enhance the recovery of phenolics and flavonoids from GL, GS and ML. Also in current study, antioxidant, antibacterial and anticancer activity has been suggested to appear a clear positive relationship with the total phenolic material. This study has proved that the Egyptian GL, GS and ML are rich sources of valuable phytochemicals and nutrients that can serve as a potential source of nutraceuticals and multifunctional food additives (antimicrobial, antioxidant, and anticancer). Phenolic compounds recovered from GL, GS and ML may have a potential role in fighting the COVID-19.

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Section: Anticancer Activitymentioning

confidence: 99%

Biological activities of Egyptian grape and mulberry by-products and their potential use as natural sources of food additives and nutraceuticals foods

Abdel-Khalek

Mattar

2022

Food Measure

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“…Shu et al, 2021, isolated guangsangon E compound from white mulberry leaves, with the ability to inhibit cell proliferation, induce autophagy and apoptosis in lung and nasopharyngeal cancer cells, and increase the flow of autophagy by increasing lysosomal activity and the fusion of autophagosomes and lysosomes. Guangsangon E activates the stress of the endoplasmic reticulum, which is involved in inducing autophagy, by accumulating reactive oxygen species, eventually attenuating autophagy-mediated cell death [135].…”

Section: Anticancer Activitymentioning

confidence: 99%

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

Memete

Timar

Vuşcan

et al. 2022

Plants

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In recent years, mulberry has acquired a special importance due to its phytochemical composition and its beneficial effects on human health, including antioxidant, anticancer, antidiabetic and immunomodulatory effects. Botanical parts of Morus sp. (fruits, leaves, twigs, roots) are considered a rich source of secondary metabolites. The aim of our study was to highlight the phytochemical profile of each of the botanical parts of Morus tree, their health benefits and applications in food industry with an updated review of literature. Black and white mulberries are characterized in terms of predominant phenolic compounds in correlation with their medical applications. In addition to anthocyanins (mainly cyanidin-3-O-glucoside), black mulberry fruits also contain flavonols and phenolic acids. The leaves are a rich source of flavonols, including quercetin and kaempferol in the glycosylated forms and chlorogenic acid as predominant phenolic acids. Mulberry bark roots and twigs are a source of prenylated flavonoids, predominantly morusin. In this context, the exploitation of mulberry in food industry is reviewed in this paper, in terms of developing novel, functional food with multiple health-promoting effects.

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“…Flavonoids from mulberry leaves (FML) are one of the main functional components of mulberry leaf extracts, which are edible food and widely used as a kind of traditional Chinese medicine. It has been reported that mulberry leaf extracts such as FML possess multiple biological activities, such as antioxidant, improving skeletal muscle function, cardioprotective, and anti-cancer (23)(24)(25)(26). In addition, there is evidence showing that mulberry leaf extracts confer anti-obesity effects (Figure 2).…”

Section: Plant Extracts In Obesity: Potential Implication Of the Gut Microbiota Mulberry Leaf Extractsmentioning

confidence: 99%

Plant Extracts in Obesity: A Role of Gut Microbiota

et al. 2021

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Obesity has become one of the most serious chronic diseases threatening human health. Its occurrence and development are closely associated with gut microbiota since the disorders of gut microbiota can promote endotoxin production and induce inflammatory response. Recently, numerous plant extracts have been proven to mitigate lipid dysmetabolism and obesity syndrome by regulating the abundance and composition of gut microbiota. In this review, we summarize the potential roles of different plant extracts including mulberry leaf extract, policosanol, cortex moutan, green tea, honokiol, and capsaicin in regulating obesity via gut microbiota. Based on the current findings, plant extracts may be promising agents for the prevention and treatment of obesity and its related metabolic diseases, and the mechanisms might be associated with gut microbiota.

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A novel Diels–Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death

Cited by 27 publications

References 43 publications

Biological activities of Egyptian grape and mulberry by-products and their potential use as natural sources of food additives and nutraceuticals foods

Biological activities of Egyptian grape and mulberry by-products and their potential use as natural sources of food additives and nutraceuticals foods

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

Plant Extracts in Obesity: A Role of Gut Microbiota

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