A novel disposable self-adhesive inked paper device for electrochemical sensing of dopamine and serotonin neurotransmitters and biosensing of glucose

Orzari, Luiz Otávio; Freitas, Rafaela Cristina de; Andreotti, Isabela Aparecida de Araujo; Gatti, Alexandre; Janegitz, Bruno C.

doi:10.1016/j.bios.2019.05.015

Cited by 66 publications

(24 citation statements)

References 56 publications

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“…Paper electrodes, also called electrochemical paper-based analytical devices (ePADs) or paper-based electrochemical devices (PEDs), have been successfully applied in pharmaceutical, biological, food, and environmental analysis (9,(16)(17)(18)(19)(20)(21)(22)(23)(24). Also, in forensic analysis they have been employed to analyze analgesics and sedatives in whiskeys (25).…”

mentioning

confidence: 99%

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

Ribeiro

Bento

Ipólito

et al. 2020

Journal of Forensic Sciences

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The need for agile and proper identification of drugs of abuse has encouraged the scientific community to improve and to develop new methodologies. The drug lysergic acid diethylamide (LSD) is still widely used due to its hallucinogenic effects. The use of voltammetric methods to analyze narcotics has increased in recent years, and the possibility of miniaturizing the electrochemical equipment allows these methods to be applied outside the laboratory; for example, in crime scenes. In addition to portability, the search for affordable and sustainable materials for use in electroanalytical research has grown in recent decades. In this context, employing paper substrate, graphite pencil, and silver paint to construct paper-based electrodes is a great alternative. Here, a paper-based device comprising three electrodes was drawn on 300 g/m 2 watercolor paper with 8B pencils, and its efficiency was compared to the efficiency of a commercially available screen-printed carbon electrode. Square wave voltammetry was used for LSD analysis in aqueous medium containing 0.05 mol/L LiClO 4. The limits of detection and quantification were 0.38 and 1.27 μmol/L, respectively. Both electrodes exhibited a similar voltammetric response, which was also confirmed during analysis of a seized LSD sample, with recovery of less than 10%. The seized samples were previously analyzed by GCMS technique, employing the full scan spectra against the software spectral library. The electrode selectivity was also tested against 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine. It was possible to differentiate these compounds from LSD, indicating that the developed paper-based device has potential application in forensic chemistry analyses.

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mentioning

confidence: 99%

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

Ribeiro

Bento

Ipólito

et al. 2020

Journal of Forensic Sciences

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“…The LOD and LOQ (S/N = 3) are calculated to be 0.66 μM and 2.19 μM respectively with wide linear range (7.5-300 μM) of analyte. Therefore, the LOD and linear range of present 5-HT sensing studies using SPCE/ZCNT 0.1 NCs is significantly good in comparison to the other reported materials 21,[79][80][81][82][83][84][85][86][87] ; which is shown in Table 3. As per our best knowledge, ease synthesized one dimensional (1D) (ZnO NRs) 1 www.nature.com/scientificreports/ electrochemical 5-HT sensing studies.…”

Section: Eds Analysismentioning

confidence: 64%

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Mullani

Dhodamani

Shellikeri

et al. 2020

Sci Rep

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Herein, the efficient serotonin (5-HT) sensing studies have been conducted using the (ZnO NRs)1−x(CNs)x nanocomposites (NCs) having appropriate structural and electrochemical properties. Initially, the different compositions of ZnO nanorods (NRs), with varying content of carbon nanostructures (CNs=MWCNTs and RGO), are prepared using simple in-situ wet chemical method and thereafter these NCs have been characterized for physico-chemical properties in correlation to the 5-HT sensing activity. XRD Rietveld refinement studies reveal the hexagonal Wurtzite ZnO NRs oriented in (101) direction with space group ‘P63mc’ and both orientation as well as phase of ZnO NRs are also retained in the NCs due to the small content of CNs. The interconnectivity between the ZnO NRs with CNs through different functional moieties is also studied using FTIR analysis; while phases of the constituents are confirmed through Raman analysis. FESEM images of the bare/NCs show hexagonal shaped rods with higher aspect ratio (4.87) to that of others. BET analysis and EIS measurements reveal the higher surface area (97.895 m2/g), lower charge transfer resistance (16.2 kΩ) for the ZCNT 0.1 NCs to that of other NCs or bare material. Thereafter, the prepared NCs are deposited on the screen printed carbon electrode (SPCE) using chitosan as cross-linked agent for 5-HT sensing studies; conducted through cyclic voltammetry (CV) and square wave voltammetry (SWV) measurements. Among the various composites, ZCNT0.1 NCs based electrodes exhibit higher sensing activity towards 5-HT in accordance to its higher surface area, lower particle size and lower charge transfer resistance. SWV measurements provide a wide linear response range (7.5–300 μM); lower limit of detection (0.66 μM), excellent limit of quantification (2.19 μM) and good reproducibility to ZCNT 0.1 NCs as compared to others for 5-HT sensing studies.

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“…The detection based on the pH-sensitive liposomes was tested with a mixture containing 1 mg/mL concentrations of glucose, dopamine, and serotonin; these concentrations are much higher than the typical concentrations in body fluid. (30) The response of the mixture was little different from that of pure glucose after liposome addition in Fig. 3, while the mixture without glucose showed the same response as that before liposome addition.…”

Section: Resultsmentioning

confidence: 79%

Glucose Detection Based on pH-sensitive Liposomes

Kang¹,

Park²

2021

Sensors and Materials

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pH-sensitive liposomes were employed to amplify the detection of glucose. Glucose oxidase (GOx) covalently immobilized on magnetic particles and pH-sensitive liposomes encapsulating ferricyanide were added to a cyclic voltammeter cell solution in which glucose was distributed. The conversion of glucose into gluconic acid appeared to decrease the pH, which reduced the electrostatic repulsion between the headgroups of weakly acidic 1,2-dipalmitoyl-sn-glycero-3succinate. The reduction destabilized the liposomes, which released the potassium ferricyanide encapsulated inside them. The effects of the glucose concentration and pH value were investigated. It was necessary to add more than 10 µL of 0.5 μg/mL glucose solution to the 5 mL cyclic voltammeter cell solution to observe a response. The activity of GOx was reversible with respect to the pH change between 7 and 5. The sensitivity of this detection was almost identical to that of comparable techniques such as the use of a field-effect transistor. Therefore, the methodology developed in this study is feasible as a portable and ultrasensitive method.

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A novel disposable self-adhesive inked paper device for electrochemical sensing of dopamine and serotonin neurotransmitters and biosensing of glucose

Cited by 66 publications

References 56 publications

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

Structural refinement and electrochemical properties of one dimensional (ZnO NRs)1−x(CNs)x functional hybrids for serotonin sensing studies

Glucose Detection Based on pH-sensitive Liposomes

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