A novel drug delivery of 5-fluorouracil device based on TiO 2 /ZnS nanotubes

Faria, Henrique Antonio Mendonça; Queiroz, Álvaro Antônio Alencar de

doi:10.1016/j.msec.2015.06.008

Cited by 41 publications

(29 citation statements)

References 40 publications

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“…These new drug delivery systems permit high delivery efficiency, precise control of the dose, sustained drug release and significant reduction in drugs’ side effects [ 30 ]. TiO 2 NP have also been reported to be effective as carriers for various drugs, such as sodium phenytoin, valproic acid, temozolomide, 5-fluorouracil, daunorubicin, doxorubicin and paclitaxel [ 30 , 32 , 33 , 34 , 35 ]. In our study, we have selected to test two different TiO 2 NP.…”

Section: Introductionmentioning

confidence: 99%

Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials

Cristo

Maguire

Quillan

et al. 2018

IJERPH

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Nanoparticles (NP)-based inhalation systems for drug delivery can be administered in liquid form, by nebulization or using pressurized metered dose inhalers, and in solid form by means of dry powder inhalers. However, NP delivery to the lungs has many challenges including the formulation instability due to particle-particle interactions and subsequent aggregation, causing poor deposition in the small distal airways and subsequent alveolar macrophages activity, which could lead to inflammation. This work aims at providing an in vitro experimental design for investigating the correlation between the physico-chemical properties of NP, and their biological behavior, when they are used as NP-based inhalation treatments, comparing two different exposure systems. By means of an aerosol drug delivery nebulizer, human lung cells cultured at air–liquid interface (ALI) were exposed to two titanium dioxide NP (NM-100 and NM-101), obtained from the JRC repository. In parallel, ALI cultures were exposed to NP suspension by direct inoculation, i.e., by adding the NP suspensions on the apical side of the cell cultures with a pipette. The formulation stability of NP, measured as hydrodynamic size distributions, the cell viability, cell monolayer integrity, cell morphology and pro-inflammatory cytokines secretion were investigated. Our results demonstrated that the formulation stability of NM-100 and NM-101 was strongly dependent on the aggregation phenomena that occur in the conditions adopted for the biological experiments. Interestingly, comparable biological data between the two exposure methods used were observed, suggesting that the conventional exposure coupled to ALI culturing conditions offers a relevant in vitro tool for assessing the correlation between the physico-chemical properties of NP and their biological behavior, when NP are used as drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials

Cristo

Maguire

Quillan

et al. 2018

IJERPH

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“…24 Nanotubules are promising candidates as drug-delivery systems for increasing the amounts of calcium and phosphorous on the surfaces. 25 Among these nanostructures, nanoparticles have been widely applied because of the following advantages: increasing integrin molecule clustering to enhance adhesion; facilitating matrix flow by forming interconnected microporous structures; and enabling easy fabrication of dense nano-arrays. [26][27][28] Recently, numerous approaches, including physical, biological, optical, and chemical methods, have been employed to fabricate nanoparticles with titanium surfaces to improve BIC.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with hierarchical micro/nano-structures obtained by hydrofluoric acid treatment

Liang¹,

Xu²,

Shen³

et al. 2017

IJN

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An easier method for constructing the hierarchical micro-/nano-structures on the surface of dental implants in the clinic is needed. In this study, three different titanium surfaces with microscale grooves (width 0.5–1, 1–1.5, and 1.5–2 μm) and nanoscale nanoparticles (diameter 20–30, 30–50, and 50–100 nm, respectively) were obtained by treatment with different concentrations of hydrofluoric acid (HF) and at different etching times (1%, 3 min; 0.5%, 12 min; and 1.5%, 12 min, respectively; denoted as groups HF1, HF2, and HF3). The biological response to the three different titanium surfaces was evaluated by in vitro human bone marrow-derived mesenchymal stem cell (hBMMSC) experiments and in vivo animal experiments. The results showed that cell adhesion, proliferation, alkaline phosphatase activity, and mineralization of hBMMSCs were increased in the HF3 group. After the different surface implants were inserted into the distal femurs of 40 rats, the bone–implant contact in groups HF1, HF2, and HF3 was 33.17%±2.2%, 33.82%±3.42%, and 41.04%±3.08%, respectively. Moreover, the maximal pullout force in groups HF1, HF2, and HF3 was 57.92±2.88, 57.83±4.09, and 67.44±6.14 N, respectively. The results showed that group HF3 with large micron grooves (1.5–2.0 μm) and large nanoparticles (50–100 nm) showed the best bio-functionality for the hBMMSC response and osseointegration in animal experiments compared with other groups.

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“…Different delivery systems have been used to ensure prolonged and sustained release of 5-FU. Examples include hydrogels [8], biodegradable polymers [9], layered inorganic nanocomposites [6], mesoporous organosilica [10], magnetic nanocarriers [7], the clay mineral montmorillonite [11], organic-modified montmorillonite [12], hybrid TiO 2 /ZnO nanotubes [13], porous silica calcium phosphate nanocomposites [14], mesoporous silica systems [15], and thiol-functionalized mesoporous silica nanoparticles [16]. Recently, zeolites have been used in biomedical applications due to their biocompatibility and low toxicity [17,18].…”

Section: Introductionmentioning

confidence: 99%

Use of Zeolite ZSM-5 for Loading and Release of 5-Fluorouracil

Al-Thawabeia

Hodali

2015

Journal of Chemistry

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Samples of zeolite ZSM-5 have been synthesized in both the sodium form (ZSM-5) and the acid activated form (H-ZSM-5). In addition, each of these two forms was prepared in the two molar SiO2/Al2O3ratios of 169 and 15. All samples of these ZSM-5 derivatives were characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption isotherms, thermal gravimetric analysis (TGA), X-ray fluorescence (XRF), and scanning electron microscopy (SEM). The samples were successfully loaded with the anticancer drug 5-fluorouracil (5-FU) with loading capacities varying from 22% (for the sodium form having the lower molar SiO2/Al2O3ratio of 15, ZSM-5-(15)) to 43% (for the corresponding acid form, H-ZSM-5-(15)). Percent release of the drug-loaded ZSM-5 samples into simulated body fluid (SBF) was measured at pH 7.4 and 37°C. The results showed a slight variation in the % release within the range 84–93%, while the first-order rate constant (k) varied from 2.2 h−1for ZSM-5-(15) to 3.9 h−1for H-ZSM-5-(15). It was interesting to note that at the higher molar SiO2/Al2O3ratios of 169, both the sodium form, ZSM-5-(169), and the acid form, H-ZSM-5-(169), exhibit an intermediate efficiency in either % loading (38%) or first-order kinetic release constant (k= 2.9 h−1).

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A novel drug delivery of 5-fluorouracil device based on TiO 2 /ZnS nanotubes

Cited by 41 publications

References 40 publications

Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials

Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials

Osteogenic activity of titanium surfaces with hierarchical micro/nano-structures obtained by hydrofluoric acid treatment

Use of Zeolite ZSM-5 for Loading and Release of 5-Fluorouracil

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