A Novel Drug Delivery System: Review on Microspheres

Raj, Hans; Sharma, Shagun; Sharma, Ankita; Verma, Kapil Kumar; Chaudhary, Amit

doi:10.22270/jddt.v11i2-s.4792

Cited by 15 publications

(9 citation statements)

References 20 publications

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“…Microsphere drug delivery systems are increasingly used in tissue defect repair and regeneration due to their injectability and sustained-release performance [35,36]. However, there are still many problems with traditional systems [37]. For example, the microfluidic method is difficult to achieve in mass production.…”

Section: Discussionmentioning

confidence: 99%

Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment

Dong

Yang

et al. 2023

Biofabrication

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Osteomyelitis, caused by purulent bacteria invading bone tissue, often occurs in long bones and seriously affects the physical and mental health and working ability of patients, and even endangers life. However, due to its cavity structure, osteomyelitis tends to occur inside the bone and lacks an effective treatment, which needs anti-inflammatory and repair of bone defects. Here, we developed an injectable hydrogel micro microspheres loaded with naringin and bone marrow mesenchymal stem cells (BMSCs), which are not only anti-inflammatory; but also osteogenic. These homogeneous microspheres are rapidly fabricated by the electro-assisted bioprinting method, with sizes from 200 to 1000 μm. Interestingly, it was found that microspheres with relatively small diameters (200 μm) were more conducive to the initial cell attachment, growth, spread, and later osteogenic differentiation. It can achieve an effective treatment for tibial osteomyelitis in rats within six weeks, proving that it has a positive prospect for clinical application.

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Section: Discussionmentioning

confidence: 99%

Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment

Dong

Yang

et al. 2023

Biofabrication

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“…1.3.11.8. Microsphere Based Gels [27][28][29] Microspheres are also known as microparticles which are very small spherical particles within range of 1 µm to 1000 µm. The microspheres consist of biodegradable synthetic polymers or protein and free flowing powder.…”

Section: Advantages Of Solid Dispersionmentioning

confidence: 99%

A Review Article: Formulation of Topical Gel by QbD Approach

Karamkar¹,

Agrawal²,

Chatap³

2023

app

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Application of drug by topical route is an alternate route for the treatment of skin diseases for systemic route. The skin diseases can be treated by administration of drug by local application and may avoid first pass metabolism. It minimizes systemic side effects and when applied locally can be removed easily if any side effects occur like, irritation, skin rash, redness at the application site. The topical drug delivery has been beneficial for longer period of time because of availability of large surface area of skin which exposed to circulatory routes. Because of this route, one can be directly applied to any external body surface and it is only for local application. Amongst many types of topical dosage form delivery, gel is most likely to be used and is a patient-friendly dosage form. Due to the lack of insoluble excipients and oily bases, the gel represents better release of drug as compared to other topical drug delivery system. Nowadays, many industries follow QbD (Quality by Design) approach for the formulation of Gel to prepare a quality medicine delivery to patients. The QbD approach describes the CQA, CMA and CPP of the formulation which ensures the quality of dosage form. This review article focuses on the different dosage forms, types of gel, evaluation by taking parameters such as drug content, pH, spreadability, extrudability, viscosity, swelling index and in-vitro drug diffusion and application of QbD approach to gel formulation.

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“…The properties of the polymer significantly affect the site, mechanism and kinetics of drug release from the carrier. Two main mechanisms of drug release from the microspheres have been described: (a) the drug's diffusion and/or dissolution from the swellable or non-swellable polymer matrix, and (b) the drug's diffusion and/or dissolution governed by the erosion or dissolution of the polymer (22)(23)(24)(25)(26). The release of the drug substance from the biodegradable microspheres is a consequence of the gradual decomposition (bioerosion) of the polymer matrix, typically by hydrolysis or enzymatic degradation.…”

Section: Drug Release From Microspheresmentioning

confidence: 99%

Modeling of in vitro drug release from polymeric microparticle carriers

Djekić¹,

Ćirić²

2022

Arhiv za farmaciju

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Incorporation of active substances in polymeric microparticles (microencapsulation) is an important technological strategy used in the pharmaceutical industry to improve the functionality, quality, safety and/or therapeutic efficiency of pharmaceutical preparations for different routes of administration. The current focus of research in this field is on the encapsulation of small molecules and macromolecules into microparticles based on biocompatible synthetic polymers and biopolymers, such as polypeptides and polysaccharides, in order to achieve preferable drug release kinetics and many other advantages. Diversity in the structure and size of microparticles, choice of polymers, and manufacturing processes, allows for designing a multitude of microcarriers (e.g., monolithic matrix microspheres, hollow microcapsules, water-or oil-core microcapsules, stimulus-sensitive microcapsules), whereby their impact on biopharmaceutical profile of drugs can be manipulated. The results so far indicate that the in vitro drug release kinetics evaluation is one of the key aspects of the microparticle-type carrier characterization, where the application of the mathematical analysis (modeling) of the drug release profiles is an important tool for elucidating drug release mechanisms, as well as for evaluating the influence and optimization of formulation and process parameters in the microencapsulation procedure. The article reviews representative studies in which mathematical modeling of experimentally obtained release data was performed for microencapsulated model drugs with different physicochemical properties, as well as the relevance and potential limitations of this approach.

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A Novel Drug Delivery System: Review on Microspheres

Cited by 15 publications

References 20 publications

Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment

Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment

A Review Article: Formulation of Topical Gel by QbD Approach

Modeling of in vitro drug release from polymeric microparticle carriers

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