A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2

Zhang, Ya; Li, Ning; Xu, Ying; Liu, Xiaofang; Ma, Yi; Huang, Zhen; Luo, Hao; Hou, Changjun; Huo, Danqun

doi:10.1016/j.bioelechem.2022.108362

Cited by 19 publications

(6 citation statements)

References 32 publications

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“…The nanoMIP receptors and the sensor fabrication Table 2 shows the LOD values of some biosensors reported in recent years for the detection of HER2 in serum samples. Accordingly, our nanoMIP-SPR provides comparable or better performance than those of the other studies [15,[28][29][30][31]. Importantly, the newly developed sensor allows the real-time detection of HER2 without requiring any label, signal amplification agent, or redox marker.…”

Section: Discussionmentioning

confidence: 77%

A Novel NanoMIP–SPR Sensor for the Point-of-Care Diagnosis of Breast Cancer

Erol,

Hasabnis,

Altintas

2023

Micromachines

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Simple, fast, selective, and reliable detection of human epidermal growth factor receptor 2 (HER2) is of utmost importance in the early diagnosis of breast cancer to prevent its high prevalence and mortality. Molecularly imprinted polymers (MIPs), also known as artificial antibodies, have recently been used as a specific tool in cancer diagnosis and therapy. In this study, a miniaturized surface plasmon resonance (SPR)-based sensor was developed using epitope-mediated HER2-nanoMIPs. The nanoMIP receptors were characterized using dynamic light scattering (DLS), zeta potential, Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and fluorescent microscopy. The average size of the nanoMIPs was determined to be 67.5 ± 12.5 nm. The proposed novel SPR sensor provided superior selectivity to HER2 with a detection limit (LOD) of 11.6 pg mL−1 in human serum. The high specificity of the sensor was confirmed by cross-reactivity studies using P53, human serum albumin (HSA), transferrin, and glucose. The sensor preparation steps were successfully characterized by employing cyclic and square wave voltammetry. The nanoMIP–SPR sensor demonstrates great potential for use in the early diagnosis of breast cancer as a robust tool with high sensitivity, selectivity, and specificity.

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Section: Discussionmentioning

confidence: 77%

A Novel NanoMIP–SPR Sensor for the Point-of-Care Diagnosis of Breast Cancer

Erol,

Hasabnis,

Altintas

2023

Micromachines

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“…2A). 34 Zhou et al 35 synthesized two novel bimetallic Zn and Zr based MOFs using the MOF-on-MOF method (Fig. 2B).…”

Section: Fundamentals Of Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical biosensors: rapid detection methods in wastewater-based epidemiology research

Yuan,

Shu,

et al. 2024

Environ. Sci.: Water Res. Technol.

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“…Moreover, it exhibited a linearity range of 0.03 ng/mL to 9.0 ng/mL. Moreover, Ya-Zhang et al fabricated an outstanding aptasensor by incorporating a nanocomposite into a screen-printed carbon electrode (Zhang et al, 2023b). The nanocomposite consisted of a metal organic framework, zeolitic imidazolate framework-67 (ZIF-67), and antimonene (AMNF).…”

Section: Nucleic Acid-based Electrochemical Biosensors (Nbeb)mentioning

confidence: 99%

Advances in nanocomposites-based electrochemical biosensors for the early diagnosis of breast cancer

Gamal,

Eldin,

Refaat

et al. 2024

Front. Sens.

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Regardless of many years of research work and conducting numerous clinical studies, breast cancer (BC) continues to grow among women, threatening their lives and future. Currently, it affects more than 10% of women globally. Therefore, researchers have recently redirected their endeavors toward detecting BC at an early stage, recognizing its substantial impact on survival rates, and acknowledging its immense potential for providing effective cancer treatments at this early diagnosed disease stage. The utilization of biomarker-based diagnostic techniques significantly contributes to the advancement of early detection and precision. A wide range of biomarkers is linked to every newly diagnosed BC case. Traditionally, breast cancer was diagnosed using a variety of techniques such as mammography, molecular imaging, and ultrasonography. These techniques had several drawbacks, drawing the attention of many scientists to developing new methods and strategies. Among these strategies, electrochemical biosensors have proven to be excellent alternatives to more complex and traditional detection strategies in terms of performance, accuracy, robustness, and a tremendous range of applications. In this review, the use of conventional methods for detecting BC as well as their challenges and shortcomings have been stated. Moreover, a deep discussion was given to the newly developed nanocomposite-based electrochemical bio-sensing approaches that have been exploited for the effective detection and quantification of breast cancer biomarkers.

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A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2

Cited by 19 publications

References 32 publications

A Novel NanoMIP–SPR Sensor for the Point-of-Care Diagnosis of Breast Cancer

A Novel NanoMIP–SPR Sensor for the Point-of-Care Diagnosis of Breast Cancer

Electrochemical biosensors: rapid detection methods in wastewater-based epidemiology research

Advances in nanocomposites-based electrochemical biosensors for the early diagnosis of breast cancer

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