A novel electrochemiluminescence sensor for the determination of diphenidol based on a nano-TiO2/silica sol/PVP/Ru(bpy)32+ modified gold electrode

Li, Yanqing; Yang, Lanlan; Li, Lijun; Luo, Ying; Cheng, Hao; Huang, Wenyi

doi:10.1039/c4nj02146k

Cited by 4 publications

(4 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We calculated the detection limit (DL) using the calibration line shown in Figure 4. The DL was estimated from the line slope (S) and the standard deviation ( σ zero ) for the zero dye case obtained from five different measurements of the absorption area using the relation

DL = \frac{3 σ}{S}

[26]. We conclude that the detection threshold may be around 10 nM for the Congo red dye.…”

Section: Resultsmentioning

confidence: 99%

Enhancing the optical response and biosensing capabilities of bioinspired peptide micro‐waveguides exploiting chromatic aberration

Tiwari

Roy

Mondal

et al. 2022

Journal of Biophotonics

View full text Add to dashboard Cite

Bioinspired peptide waveguides of mesoscopic length scales have established a new paradigm in photonics with possible applications in precision bioimaging, sensing, and diagnostics. Here, we improve the efficiency of coupling various constituent colors of a white light source into single self‐assembled microtube‐shaped passive peptide waveguides by employing chromatic aberration. Thus, we use a chromatically aberrated microscope objective lens to couple light into peptide waveguides. Using both numerical simulation and experiments, we show that the waveguide response displays higher quality factor, wavelength selectivity, and axial coupling range compared to a chromatically corrected standard plan‐fluoritic objective lens. We also demonstrate absorption and refractive index‐based sensing by studying the changes in the optical responses of the peptide tubes in the presence of a wide concentration range of the absorptive Congo red, and the nonabsorptive Coumarin dyes. The former understandably display a much higher response than the latter due to the low finesse of the waveguides. We obtain a detection limit of around 10 nM for Congo red, and 10 mM for Coumarin. Our study opens up possibilities for deploying such peptide microtubes for various biosensing applications utilizing spectral and waveguide characteristics.

show abstract

DL = \frac{3 σ}{S}

[26]. We conclude that the detection threshold may be around 10 nM for the Congo red dye.…”

Section: Resultsmentioning

confidence: 99%

Enhancing the optical response and biosensing capabilities of bioinspired peptide micro‐waveguides exploiting chromatic aberration

Tiwari

Roy

Mondal

et al. 2022

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…As shown in Figure 4a, the oxidation peak was identified at +1.0 V and increased when difenidol hydrochloride was added to the electrolyte solution. This was due to the synergetic effect of difenidol hydrochloride on the oxidation–reduction reactions of Ru(bpy) 3 2+ [42], by which the tertiary amino of difenidol was oxidized into radical cations.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 5b shows the comparative ECL intensities obtained, where it can be seen that BBS exhibited the best performance. The maximum ECL intensity was achieved at a pH of 7.5, because the use of a high pH value helped in the deprotonation of difenidol, and thus enhanced the luminescence signal [42]. Therefore, in subsequent experiments, we adopted BBS as the buffer solution and used it at an optimal pH of 7.5.…”

Section: Resultsmentioning

confidence: 99%

Electrochemiluminescence Sensor Based on Electrospun Three-Dimensional Carbon Nanofibers for the Detection of Difenidol Hydrochloride

Cheng

Zhou

et al. 2019

Sensors

Self Cite

View full text Add to dashboard Cite

The detection of difenidol hydrochloride, which is a drug that is widely used for treating the nausea and vomiting symptoms caused by certain diseases, has been increasingly involved in cases of suicide via overdosing and of drug poisoning in children. A novel electrochemiluminescence (ECL) sensor for the simple and effective detection of difenidol hydrochloride was fabricated by modifying a glassy carbon electrode with three-dimensional carbon nanofibers (3D-CNFs). The 3D-CNFs were synthesized by electrospinning a mixture of montmorillonite (MMT) and polyacrylonitrile, carbonizing the electrospun product, and etching it with hydrofluoric acid. The form and structure of the 3D-CNFs was analyzed via scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman microspectroscopy. According to the experimental results obtained using the modified electrodes, a good linear relationship was found between peak intensity and difenidol concentration (y = 868.14x − 61.04, R2 = 0.999), with a relatively low detection limit (8.64 × 10−10 mol·L−1 (S/N = 3)). In addition, our approach exhibited good recovery values ranging from 98.99% to 102.28%. The proposed novel ECL sensor has wide application prospects for the detection of difenidol hydrochloride.

show abstract

“…5. [9][10][11]25,26 The oxidized (Ru(bpy) 3 3+ ) and reduced (Ru(bpy) 3 + ) were generated with the changes of potential on the modified electrode surface, and two species reacted to form the excited state Ru(bpy) 3 2+ *, which could emit ECL via annihilation. For Ru(bpy) 3 2+ -VpCl, Ru(bpy) 3 2+ on the electrode surface lost an electron and was oxidized to Ru(bpy) 3 3+ under certain oxidation potential, and VpCl at the vicinity of the electrode * that relaxed to the ground state and emitted light with max ³ 620 nm.…”

confidence: 99%

Development of Electrochemiluminecence Sensor for Verapamil Hydrochloride Based on TiO2 sol/ZnO@Ag/Silica sol-Ru(bpy)32+ Modified Pyrolytic Graphite Electrode

Luo¹,

Huang

et al. 2022

Electrochemistry

Self Cite

View full text Add to dashboard Cite

A sensitive solid-state electrochemiluminesence (ECL) sensor for verapamil hydrochloride (VpCl) was fabricated based on the film formability of TiO 2 sol and electrocatalysis of ZnO@Ag. The immobilization of tris(2, 2′bipyridine) ruthenium (II) (Ru(bpy) 3 2+) by using TiO 2 sol/ZnO@Ag/silica sol composite exhibited stable ECL behaviors, and a sensitive and selective method was developed for VpCl determination. Under the optimal conditions, the ECL response of the sensor showed a linear correlation to the concentration of VpCl in the range of 1.0 × 10 −7 -1.0 × 10 −4 mol L −1 (R 2 = 0.9832) with a detection limit of 7.00 × 10 −9 mol L −1 (S/N = 3). The RSD of ECL response was 2.07 % for 1.0 × 10 −5 mol L −1 VpCl under 10 continuous cyclic scans. The spiked recovery was 97.90-104.50 % for determination of real VpCl sample. The proposed method exhibited selectivity and sensitivity for VpCl, and improved efficiency of Ru(bpy) 3 2+ .

show abstract

A novel electrochemiluminescence sensor for the determination of diphenidol based on a nano-TiO₂/silica sol/PVP/Ru(bpy)₃²⁺ modified gold electrode

Abstract: Compared with the bare electrode, the sensitizing effect of diphenidol on Ru(bpy)32+ was obvious on the modified electrode.

Cited by 4 publications

References 20 publications

Enhancing the optical response and biosensing capabilities of bioinspired peptide micro‐waveguides exploiting chromatic aberration

Enhancing the optical response and biosensing capabilities of bioinspired peptide micro‐waveguides exploiting chromatic aberration

Electrochemiluminescence Sensor Based on Electrospun Three-Dimensional Carbon Nanofibers for the Detection of Difenidol Hydrochloride

Development of Electrochemiluminecence Sensor for Verapamil Hydrochloride Based on TiO<sub>2</sub> sol/ZnO@Ag/Silica sol-Ru(bpy)<sub>3</sub><sup>2+</sup> Modified Pyrolytic Graphite Electrode

Contact Info

Product

Resources

About