A Novel Entry to Pyrido[4,3-b]carbazoles: An Efficient Synthesis of Ellipticine

Alcaloides indólicos de cascas de Aspidosperma vargasii e A. desmanthum

“…O espectro de ESI-HR-MS possibilitou a determinação da fórmula molecular do alcaloide 1 em C 17 H 14 N 2 . Os dados espectrais de 1 foram também comparados com a literatura, 9 permitindo identificá-lo como elipticina (1). A elipticina também foi isolada de outras espécies, como A. williamsii, 4 A. dasycarpon, A. ulei, 17 A. subincanum, 18 A. gilbertii 19 e Ochrosia elliptica labill.…”

Photochemische Reaktionen als Schlüsselschritte in der Naturstoffsynthese

“…Abbildung 2 fasst die Produkte einiger erfolgreich abgeschlossener Synthesen zusammen, wobei die jeweils grau markierte Bindung durch [6p]-Photocyclisierung entstand. Zu diesen Naturstoffen gehören (+)-Rebeccamycin (12), [19] die Dictyodendrine B (13), C und E, [20] Methoxatin (14), [21] Ellipticin (15), [22] das StaurosporinAglykon (Staurosporinon oder K252c, 16), [23] (+)-Staurosporin, [24] (+)-RK286c, [24] (+)-MLR-52, [24] (À)-TAN-1030a, [24] Furostifolin [25] sowie das aus Aspidosperma gilbertii isolierte Indolalkaloid 17.…”

Pattern recognition methods investigation of ellipticines structure–activity relationships

“…Ellipticine derivatives represent useful samples for such a purpose because lots of synthetic compounds of this group have been prepared and their structure-activity relationships have been screened [13][14][15][16]. In the last 10 years a great number of new synthetic routes have been proposed to ellipticines which encourage further investigation of active derivatives [15][16][17][18][19][20]. The main reasons for interest in ellipticines for clinical purposes are their limited toxic side effects and their complete lack of hematological toxicity [21].…”