A novel experimental approach to the control of postburn transeschar caloric loss

Jelenko, Carl; Wheeler, M L

doi:10.1016/0022-4804(68)90059-0

Cited by 2 publications

(2 citation statements)

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“…These data are partially different from what is found here, and this might be because of the differences between the structure and composition of the membranes. Normal stratum corneum pathways include mainly of lamellar lipid structure (27), while burn eschar is a protein–water semisolid membrane with some lipid component (8,28).…”

Section: Resultsmentioning

confidence: 99%

“…To the best of our knowledge, there is no available data in the literature on the thermal analysis of burn eschar. Burn eschar is a proteinous structure with some lipid components (28). It has been shown for zein (the most abundant protein in the vitreous region of the corn endosperm) that hydration decreases enthalpy of protein glass transition temperature (29).…”

Section: Thermal Analysismentioning

confidence: 99%

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A mechanistic study on the effect of ethanol and importance of water on permeation of drugs through human third‐degree burn eschar

Ghaffari

Moghimi

Manafi

et al. 2011

International Wound Journal

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Ethanol that affects hydration of skin and used in wound treatment formulations was studied here for its effect on permeation of drugs through burn eschar and to investigate the presence of a porous pathway in this barrier. In this study, permeations of clindamycin phosphate (CP, hydrophilic) and diazepam (lipophilic) through human burn eschar were investigated in the presence and absence of ethanol. Permeability coefficients (K(p) ) of CP and diazepam through hydrated eschar were calculated to be 13·1 × 10(-3) and 17·4 × 10(-3) cm/h respectively. These K(p) values were decreased by about 1·5-5·3 and 2-10·7 times respectively upon the addition of 20-70% ethanol. Increased amount of ethanol decreased permeation flux of CP (2-20 times) and increased that of diazepam (3-80 times) from saturated solutions. Thermal analysis showed that ethanol dehydrates eschar and also changes its internal proteineous structure. Such changes were concluded to be the main reasons behind decreased K(p) of both drugs. Comparison of K(p) data suggests the possibility and importance of a pore pathway in permeation of both drugs through the hydrated burn eschar. Present results show that ethanol, and possibly other dehydrating agents, can decrease the permeability of eschar and that this effect should be considered in formulation developments.

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Section: Resultsmentioning

confidence: 99%

Section: Thermal Analysismentioning

confidence: 99%