A Novel Fluid Resuscitation Therapy for Hemorrhagic Shock

Roy, Joshua; Graham, Matthew; Griffin, Adam M.; Gainer, John L.

doi:10.1097/00024382-199809000-00010

Cited by 29 publications

(14 citation statements)

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“…However, after 24 h, the MP was probably no longer at its peak activity. Con sideration of corticosteroids as emergency therapy for DCS persists (10) based on their anti-inflammatory ac tion (5,42) and because some trials showed long-term benefits from MP in patients suffering from spinal cord trauma (6). Treatment of DCS with another glucocorti coid, Dexamethasone, did not appear to influence the outcome of DCS (20).…”

Section: Methylprednisolone (Mp)mentioning

confidence: 99%

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Montcalm-Smith¹,

Fahlman²,

Kayar³

2008

asem

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Section: Methylprednisolone (Mp)mentioning

confidence: 99%

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Montcalm-Smith¹,

Fahlman²,

Kayar³

2008

asem

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“…Crocetin has been reported to have multiple medical properties including scavenging oxygen free radicals (8), inhibiting tumor cell proliferation (11), and preventing atherosclerosis (12). It has also been reported that crocetin increases oxygen diffusion (13), recovers cellular ATP (14), and improves survival in a rat control of hemorrhagic shock (15,16).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Crocetin on Hemorrhagic Shock–Induced Acute Renal Failure in Rats

Wang¹,

Yan²,

Liu³

et al. 2012

Shock

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Multiple organ failure is a common outcome of hemorrhagic shock followed by resuscitation, and the kidney is one of the prime target organs involved. The main objective of the study was to evaluate whether crocetin, a natural product from Gardenia jasminoides Ellis, has beneficial effects on renal dysfunction caused by hemorrhagic shock and resuscitation in rats. Anesthetized rats were bled to reduce mean arterial blood pressure to 35 (SD, 5) mmHg for 60 min and then were resuscitated with their withdrawn shed blood and normal saline. Crocetin was administered via the duodenum at a dose of 50 mg/kg 40 min after hemorrhage. The increase in creatinine and blood urea nitrogen was significantly reduced at 2 h after hemorrhage and resuscitation in crocetin-treated rats. The increases in renal nitric oxide, tumor necrosis factor α, and interleukin 6 were also attenuated by crocetin. Hemorrhagic shock resulted in a significant elevation in malondialdehyde production and was accompanied by a reduction in total superoxide dismutase activity, activation of nuclear factor κB, and overexpression of inducible nitric oxide synthase. These changes were significantly attenuated by crocetin at 2 h after resuscitation. These results suggested that crocetin blocks inflammatory cascades by inhibiting production of reactive oxygen species and restoring superoxide dismutase activity to ameliorate renal dysfunction caused by hemorrhage shock and resuscitation.

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“…The severity and the mortality after shock is strongly associated with decreased oxygen consumption (2,4). Indeed, anaphylactic shock is accompanied by decreased oxygen consumption (5,6).…”

Section: Introductionmentioning

confidence: 99%

Oxygen Consumption, Assessed With the Oxygen Absorption Spectrophotometer, Decreases Independently of Venoconstriction During Hepatic Anaphylaxis in Perfused Rat Liver

Cui

Shibamoto²,

Ruan³

et al. 2006

Shock

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Anaphylactic shock is accompanied by a decrease in oxygen consumption. However, it is not well known whether oxygen consumption decreases during local anaphylactic reaction in liver. We determined the effects of anaphylaxis and norepinephrine on oxygen consumption in isolated rat livers perfused portally and recirculatingly at constant flow with blood (hematocrit, 12%). Oxygen consumption was continuously measured by monitoring the portal-hepatic venous oxygen saturation differences using the absorption spectrophotometer, the probes of which were built in perfusion lines. Hepatic anaphylaxis was induced by an injection of ovalbumin (0.01 or 0.1 mg) into the perfusate of the isolated liver of the rat sensitized with subcutaneous ovalbumin (1 mg). Hepatic venoconstriction and liver weight loss were similarly observed in response to norepinephrine (0.01-10 micromol L(-1)) and anaphylaxis. However, hepatic anaphylaxis reduced oxygen consumption, whereas norepinephrine increased it. There was a possibility that anaphylactic venoconstriction could reduce the perfused surface area, resulting in decreased oxygen consumption. However, pretreatment with a vasodilator of sodium nitroprusside substantially attenuated venoconstriction but not the decrease in oxygen consumption during anaphylaxis. Thus, we conclude that local hepatic anaphylaxis decreases oxygen consumption independently of venoconstriction in isolated blood-perfused rat livers.

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A Novel Fluid Resuscitation Therapy for Hemorrhagic Shock

Cited by 29 publications

References 0 publications

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

Protective Effect of Crocetin on Hemorrhagic Shock–Induced Acute Renal Failure in Rats

Oxygen Consumption, Assessed With the Oxygen Absorption Spectrophotometer, Decreases Independently of Venoconstriction During Hepatic Anaphylaxis in Perfused Rat Liver

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