Fault diagnosis and prognosis methods are the most useful tools for risk and reliability analysis in food processing systems. Proactive diagnosis techniques such as failure mode and effect analysis (FMEA) are important for detecting all probable failures and facilitating the risk analysis process. However, significant uncertainties exist in the classical-FMEA when it comes to ranking the risk priority numbers (RPNs) of failure modes. Such uncertainties may have an impact on the food sector’s operational safety and maintenance decisions. To address these issues, this research provides a unique FMEA framework for risk analysis within an edible oil purification facility that is based on certain well-known intelligent models. Fuzzy inference systems (FIS), adaptive neuro-fuzzy inference systems (ANFIS), and support vector machine (SVM) models are among those used. The findings of the comparison of the proposed FMEA framework with the classical model revealed that intelligent strategies were more effective in ranking the RPNs of failure modes. Based on the performance criteria, it was discovered that the SVM algorithm classifies the failure modes more accurately and with fewer errors., e.g., RMSE = 7.30 and MAPE = 13.19 with that of other intelligent techniques. Hence, a sensitivity FMEA analysis based on the SVM algorithm was performed to put forward suitable maintenance actions to upgrade the reliability and safety within food processing lines.