A Novel Formula Comprising Wolfberry, Figs, White Lentils, Raspberries, and Maca (WFWRM) Induced Antifatigue Effects in a Forced Exercise Mouse Model

Yang, Caixia; Yang, Jingyan; Tan, Li; Tang, Pan; Pen, Ting; Gao, Tinghui; Liu, Sijing; Guo, Jianbin

doi:10.1155/2022/3784580

Cited by 3 publications

(2 citation statements)

References 60 publications

(55 reference statements)

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“…The normal function of LDH in cells is to catalyze the interconversion between pyruvate and lactate ( Majid, 2022 ). BUN is a by-product of metabolic proteins that is produced by the body after excessive glycogen consumption, and it represents a sensitive parameter related to fatigue ( Yang et al, 2022 ). The lower the physical endurance of an individual, the greater the increase in BUN levels during physical exertion ( Lee et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

et al. 2022

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ObjectivesAging is a process that involves comprehensive physiological changes throughout the body, and improvements in the exercise capacity of individuals may delay aging and relieve fatigue. Probiotics are subject to ongoing research to investigate their antioxidant properties. The purpose of this study was to investigate the effect of the probiotic Lactobacillus plantarum KSFY01 (L. plantarum KSFY01) on exercise tolerance in mice induced into a state of accelerated physiological aging by oxidative stress.MethodsA mouse model of accelerated aging was established using D-galactose to induce oxidative stress. The bacteria L. plantarum KSFY01 was isolated from fermented yak yogurt. The effect of L. plantarum KSFY01 on the improvement of exercise capacity in aging-accelerated mice was evaluated by measuring their running time until exhaustion, histopathological sections, related biochemical indicators, and underlying gene expression.ResultsThe oral administration of L. plantarum KSFY01 prolonged the running time of mice and reduced their creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferasem (AST) levels. From this study, we observed that L. plantarum KSFY01 significantly improved the exercise capacity of mice and alleviated liver damage. Treatment with L. plantarum KSFY01 reduced the blood urea nitrogen (BUN), lactic acid (LD) accumulation, and lactate dehydrogenase (LDH) elevations produced by the accelerated aging state, and also reversed the changes in muscle glycogen (MG). Overall, L. plantarum KSFY01 could effectively improve metabolite accumulation, thereby relieving fatigue in exercised mice. The results of the antioxidant indices in vivo showed that L. plantarum KSFY01 intervention increased the activity of antioxidant enzymes, decreased the level of malondialdehyde (MDA), and restored the balance between the oxidative and antioxidant systems in fatigued mice. By investigating the underlying molecular mechanism, our results showed that L. plantarum KSFY01 intervention significantly reversed the decline in the expression levels of nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway-related factors and improved the body’s antioxidant capacity. We determined that the underlying molecular mechanism responsible for the antioxidant effect of L. plantarum KSFY01 mainly involves the activation of the Nrf2 pathway. The effect of L. plantarum KSFY01 was dose-dependent, and the expression level of Nrf2 increased with increasing dosage of the probiotic.ConclusionThis study demonstrated that the probiotic L. plantarum KSFY01 exerts antioxidant effects and improved the athletic ability of mice. These findings are of significance to the development and utilization of probiotic resources.

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Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

et al. 2022

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“…During the formal test, mice were put on the rota-rod at 15 rpm. The rotating time was recorded from the mice began to rotate until they were exhausted and dropped from the rod [26].…”

Section: Antifatigue Capacity Analysis 2: Rota-rod Testmentioning

confidence: 99%

Antifatigue Effect of Asiaticoside in Mice by Attenuating Oxidative Stress

Liu¹,

Liu²,

Yang³

et al. 2023

Discovery Medicine

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Background: Asiaticoside is one of the main components of triterpenoid saponins extracted from Centella asiatica. Asiaticoside has shown the effects of wound healing, osteoclastogenesis, anti-inflammatory, anti-cancer, and improving cognition in multiple human disease models. However, studies on the antifatigue effects of asiaticoside have not been explored. Therefore, the aim of this study was to investigate the potential antifatigue effect and underlying mechanism of asiaticoside administration on exhaustive exercise performance. Methods: Male Kunming mice were divided into four groups randomly (n = 20/group). Saline (10 mL/kg) was administered to the model control group and the other three experimental groups were fed with low (10 mg/kg), medium (20 mg/kg) and high (40 mg/kg) asiaticoside once/daily for 14 days. The antifatigue effect of asiaticoside on mice was estimated by analyzing changes in body weight, weight-loaded swimming time, rotating time, lactic acid, urea nitrogen, liver/muscle glycogen, serumal superoxide dismutase, superoxide dismutase and the liver tissues of hematoxylin and eosin (H&E) staining. Results: The results indicated that no significant differences were observed in the body weight of each group (p > 0.05). Compared with the model control group, supplementation of asiaticoside significantly prolonged the weight-loaded swimming time and rotating time; Decreased the blood lactic acid (LA), blood urea nitrogen (BUN), and serumal malonaldehyde (MDA); And increased the content of liver/muscle glycogen and serumal superoxide dismutase levels (SOD) (p < 0.05). Furthermore, the pathological results of the liver were improved greatly. The maximal effect was observed in the medium group of 20 mg/kg. Conclusions: Asiaticoside is capable of reducing the fatigue effect by regulating energy consumption, energy metabolism and improving antioxidant activity after exercise. While there are still some shortcomings in this study, our findings provide a scientific basis for developing an asiaticoside-based antifatigue supplement.

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Factors related to MDA levels in female tiles industry workers in Grobogan, Indonesia: A cross-sectional study

Putri,

Setyaningsih,

Lestyanto

et al. 2024

BIO Web Conf.

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Malondialdehyde (MDA) is a marker of work fatigue that occurs. Work fatigue often occurs in workers, but workers do not realise that continuous work fatigue causes health problems in the body. The damage that occurs is oxidative stress in the body that produces the end product, MDA. We conducted a cross-sectional study on as many as 96 home industry workers making tiles in Karang Asem, Grobogan, Central Java, Indonesia. We identified individual factors, individual habitual factors, occupational factors, and work environment factors during the study period and correlated these factors with workers’ MDA levels. MDA is measured using an ELISA reader. Data analysis used the Rank-Spearman correlation test. We identified that the mean value of MDA is 8.66. The analysis correlation test between factors with MDA explained age (p = 0.001), BMI (p = 0.922), sleep quality (p = 0.000), working period (p = 0.390), workload (p = 0.002), length of work (p=0.776), awkward posture (p = 0.013), and heat stress (p = 0.040). There was a significant correlation between age, sleep quality, workload, awkward posture, and heat stress with workers’ MDA levels. Future research should examine other factors related to MDA levels.

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A Novel Formula Comprising Wolfberry, Figs, White Lentils, Raspberries, and Maca (WFWRM) Induced Antifatigue Effects in a Forced Exercise Mouse Model

Cited by 3 publications

References 60 publications

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

Antifatigue Effect of Asiaticoside in Mice by Attenuating Oxidative Stress

Factors related to MDA levels in female tiles industry workers in Grobogan, Indonesia: A cross-sectional study

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