2018
DOI: 10.1111/jphp.12958
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A novel formulation of zolpidem for direct nose-to-brain delivery: synthesis, encapsulation and intranasal administration to mice

Abstract: The polyelectrolyte shell deposited together with zolpidem enhances the loading efficacy of the microcontainers. In vivo experiments on mice demonstrate increase in anxiolytic effect of zolpidem in microcontainers compared with upon intranasal administration of free medicine.

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Cited by 15 publications
(10 citation statements)
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“…Another interesting example of vaterite carriers’ effective use in intranasal drug delivery was reported for a novel formulation of zolpidem (Ambien) [ 88 ]. Vaterite microparticles (3.5 μm ± 0.7 μm), preliminarily coated with a diethylaminoethyl-dextran/hyaluronic acid shell, were explored for nasal delivery of this anxiolytic drug in mice.…”
Section: Drug Delivery In Vivomentioning
confidence: 99%
“…Another interesting example of vaterite carriers’ effective use in intranasal drug delivery was reported for a novel formulation of zolpidem (Ambien) [ 88 ]. Vaterite microparticles (3.5 μm ± 0.7 μm), preliminarily coated with a diethylaminoethyl-dextran/hyaluronic acid shell, were explored for nasal delivery of this anxiolytic drug in mice.…”
Section: Drug Delivery In Vivomentioning
confidence: 99%
“…A diethylaminoethyl-dextran (DAEDEX)/HA mixture was employed as shell of mesoporous Calcium carbonate particles loaded with the anxiolitic drug zolpidem (ZPD) [114]. When intranasally administrated in mice, the mucoadhesive coating improved drug bioavailability resulting in a pronounced anxiolytic effect on the animal behavior.…”
Section: Targeting By Administration Routementioning
confidence: 99%
“…While the core size and shape of CaCO 3 particles determined the loading capacity of incorporated proteins and the uptake inside cancer cells, their effective accumulation in a tumor region and subsequent cargo release are other attractive advantages . In addition, new administration routes of therapeutic agents using vaterite nanoparticles, such as intranasal and transdermal particle delivery, have recently been established. , The possibility of in vivo delivery of submicron vaterite nanoparticles to the lower respiratory tract followed by sustained drug release as a result of particle interaction with pulmonary fluid components was demonstrated by Gusliakova et al Novoselova et al have developed nanometer polymeric capsules based on vaterite nanoparticles embedded with low-molecular drugs and used them for the treatment of lung cancer cells …”
Section: Introductionmentioning
confidence: 99%
“…13 In addition, new administration routes of therapeutic agents using vaterite nanoparticles, such as intranasal and transdermal particle delivery, have recently been established. 14,15 The possibility of in vivo delivery of submicron vaterite nanoparticles to the lower respiratory tract followed by sustained drug release as a result of particle interaction with pulmonary fluid components was demonstrated by Gusliakova et al 16 Novoselova et al have developed nanometer polymeric capsules based on vaterite nanoparticles embedded with low-molecular drugs and used them for the treatment of lung cancer cells. 17 Barnase (Bn) isolated from Bacillus amyloliquefaciens is one of the promising therapeutic agents that affect metabolism inside the cell.…”
Section: Introductionmentioning
confidence: 99%