A novel framework for the removal of pacing artifacts from bio-electrical recordings

Nagahawatte, Nipuni D; Paskaranandavadivel, Niranchan; Bear, Laura; Avci, Recep; Cheng, Leo K.

doi:10.1016/j.compbiomed.2023.106673

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…The large pacing artifacts superimposed on the slow wave recordings were detected using a Hampel outlier detection filter (number of neighbors = 15; number of standard deviations = 25) and removed using an autoregressive model 39 . The model parameters of the autoregressive model were defined using data accounting for a predefined window length of 0.5 s from both sides of each artifact segment.…”

Section: Methodsmentioning

confidence: 99%

Optimization of pacing parameters to entrain slow wave activity in the pig jejunum

Nagahawatte,

Avci,

Paskaranandavadivel

et al. 2024

Sci Rep

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Pacing has been proposed as a therapy to restore function in motility disorders associated with electrical dysrhythmias. The spatial response of bioelectrical activity in the small intestine to pacing is poorly understood due to a lack of high-resolution investigations. This study systematically varied pacing parameters to determine the optimal settings for the spatial entrainment of slow wave activity in the jejunum. An electrode array was developed to allow simultaneous pacing and high-resolution mapping of the small intestine. Pacing parameters including pulse-width (50, 100 ms), pulse-amplitude (2, 4, 8 mA) and pacing electrode orientation (antegrade, retrograde, circumferential) were systematically varied and applied to the jejunum (n = 15 pigs). Pulse-amplitudes of 4 mA (p = 0.012) and 8 mA (p = 0.002) were more effective than 2 mA in achieving spatial entrainment while pulse-widths of 50 ms and 100 ms had comparable effects (p = 0.125). A pulse-width of 100 ms and a pulse-amplitude of 4 mA were determined to be most effective for slow wave entrainment when paced in the antegrade or circumferential direction with a success rate of greater than 75%. These settings can be applied in chronic studies to evaluate the long-term efficacy of pacing, a critical aspect in determining its therapeutic potential.

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Section: Methodsmentioning

confidence: 99%

Optimization of pacing parameters to entrain slow wave activity in the pig jejunum

Nagahawatte,

Avci,

Paskaranandavadivel

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

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High-resolution reconstruction of non-motorized trajectory in shared space: A new approach integrating the social force model and particle filtering

Yan

Yue

Sun

2023

Expert Systems with Applications

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Simultaneous optical imaging of gastric slow waves and contractions in the in vivo porcine stomach

Patton,

Zhang,

Wood

et al. 2024

American Journal of Physiology-Gastrointestinal and Liver Physi

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Gastric peristalsis is governed by electrical "slow waves" generally assumed to travel from proximal to distal stomach (antegrade propagation) in symmetric rings. While alternative slow wave patterns have been correlated with gastric disorders, their mechanisms and how they alter contractions remain understudied. Optical electromechanical mapping, a developing field in cardiac electrophysiology, images electrical and mechanical physiology simultaneously. Here, we translate this technology to the in-vivo porcine stomach. Stomachs were surgically exposed and a fluorescent dye (di-4-ANEQ(F)PTEA) that transduces the membrane potential (Vm) was injected through the right gastroepiploic artery. Fluorescence was excited by LEDs and imaged with one or two 256x256 pixel cameras. Motion artifact was corrected using a marker-based motion tracking method and excitation ratiometry, which cancels common-mode artifact. Tracking marker displacement also enabled gastric deformation to be measured. We validated detection of electrical activation and Vm morphology against alternative non-optical technologies. Non-antegrade slow waves and propagation direction differences between the anterior and posterior stomach were commonly present in our data. However, sham experiments suggest they were a feature of the animal preparation and not an artifact of optical mapping. In experiments to demonstrate the method's capabilities, we found that repolarization did not always follow at a fixed time behind activation "wavefronts," which could be a factor in dysrhythmia. Contraction strength and the latency between electrical activation and contraction differed between antegrade and non-antegrade propagation. In conclusion, optical electromechanical mapping, which simultaneously images electrical and mechanical activity, enables novel questions regarding normal and abnormal gastric physiology to be explored.

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A novel framework for the removal of pacing artifacts from bio-electrical recordings

Cited by 6 publications

References 32 publications

Optimization of pacing parameters to entrain slow wave activity in the pig jejunum

Optimization of pacing parameters to entrain slow wave activity in the pig jejunum

High-resolution reconstruction of non-motorized trajectory in shared space: A new approach integrating the social force model and particle filtering

Simultaneous optical imaging of gastric slow waves and contractions in the in vivo porcine stomach

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