A novel GC–MS assay method for the therapeutic drug monitoring of the atomoxetine

Kul, Aykut; Ozdemir, Murat; Önal, Armağan; Sağırlı, Olcay

doi:10.1016/j.microc.2021.105953

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…22 Many norbornene derivatives have been reported to exhibit a broad spectrum of biological activities, such as antibacterial, 23 antiviral, 24 anticancer, 25 anti-inflammatory 26 and anticholinergic activities. 27 Concerning fungicidal agents, two commercial fungicides benzovindiflupyr and isopyrazam containing the norbornene group displayed a broad spectrum of antifungal activity toward different pathogenic fungi on grains, vegetables and fruits. 28 Therefore, owing to the wide range of biological activities, norbornene can be used as an excellent pharmacophore for the development of new medicines and agrochemicals (Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, antifungal evaluation and mechanism study of novel norbornene derivatives as potential laccase inhibitors

Jin,

Yang,

Qiu

et al. 2024

Pest Management Science

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BACKGROUNDTo discover novel fungicide candidates, five series of novel norbornene hydrazide, bishydrazide, oxadiazole, carboxamide and acylthiourea derivatives (2a‐2 t, 3a‐3 f, 4a‐4 f, 5a‐5 f and 7a‐7 f) were designed, synthesized and assayed for their antifungal activity toward seven representative plant fungal pathogens.RESULTSIn the in vitro antifungal assay, some title norbornene derivatives presented good antifungal activity against Botryosphaeria dothidea, Sclerotinia sclerotiorum and Fusarium graminearum. Especially, compound 2b exhibited the best inhibitory activity toward B. dothidea with the median effective concentration (EC50) of 0.17 mg/L, substantially stronger than those of the reference fungicides boscalid and carbendazim. The in vivo antifungal assay on apples revealed that 2b had significant curative and protective effects, both of which were superior to boscalid. In the preliminary antifungal mechanism study, 2b was able to injure the surface morphology of hyphae, destroy the cell membrane integrity and increase the intracellular reactive oxygen species (ROS) level of B. dothidea. In addition, 2b could considerably inhibit the laccase activity with the median inhibitory concentration (IC50) of 1.02 μM, much stronger than that of positive control cysteine (IC50 = 35.50 μM). The binding affinity and interaction mode of 2b with laccase were also confirmed by molecular docking.CONCLUSIONThis study presented a promising lead compound for the study on novel laccase inhibitors as fungicidal agrochemicals, which demonstrate significant anti‐B. dothidea activity and laccase inhibitory activity.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Design, synthesis, antifungal evaluation and mechanism study of novel norbornene derivatives as potential laccase inhibitors

Jin,

Yang,

Qiu

et al. 2024

Pest Management Science

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“…Significant technical difficulties still exist for the use of IR in water samples. Thus, in order to overcome the technical difficulties in the employment of a single technique, combinations of these strategies were developed successfully, such as MS with gas chromatography (GC-MS) 12,13 or liquid chromatography (LC-MS), 14,15 IR with high performance liquid chromatography (HPLC-IR), 16 etc. Nevertheless, lab based instruments and inconvenient operations bring difficulties in achieving moveable and rapid operando detection.…”

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confidence: 99%