A novel GC–MS method for determination of chrysophanol in rat plasma and tissues: Application to the pharmacokinetics, tissue distribution and plasma protein binding studies

Chen, Qinhua; He, Hongsheng; Xiong, Lin

doi:10.1016/j.jchromb.2014.10.011

Cited by 24 publications

(14 citation statements)

References 21 publications

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“…The levels of chrysophanol were found to be higher in kidneys than in liver, suggesting that it is eliminated by excretion rather than by being metabolized. In addition, chrysophanol cannot easily cross the blood–brain barrier . Sreelakshmi et al .…”

Section: Pharmacologymentioning

confidence: 99%

“…In addition, chrysophanol cannot easily cross the blood-brain barrier. [88] Sreelakshmi et al [89] predict the ADME (absorption, distribution, metabolism and excretion) values by the in silico approach and found that chrysophanol has desirable intestinal absorption and medium or low bloodbrain barrier penetration ability. Subsequent research has shown that glucuronidation of anthraquinone such as chrysophanol was catalysed by UDP-glucuronyltransferase (UGT), which was usually highly expressed in the liver and intestine.…”

Section: -64 Lg/mlmentioning

confidence: 99%

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Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

101

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Objective Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8‐dihydroxy‐3‐methyl‐anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol. Key finding Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including ‘pharmacology’, ‘toxicology’ and ‘pharmacokinetics’. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy. Summary Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

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Section: Pharmacologymentioning

confidence: 99%

Section: -64 Lg/mlmentioning

confidence: 99%

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

101

View full text Add to dashboard Cite

show abstract

“…It was also reported to exert neuroprotection in animals suffering ischemia/reperfusion injury (Zhao et al, ). Moreover, the pharmacokinetic and tissue distribution studies have revealed that chrysophanol accumulates mostly in heart after oral administration (Chen et al, ). And a recent experiment provided the preliminary evidence that chrysophanol can suppress diabetic heart injury in high fat diet‐treated mice (Lian et al, ).…”

Section: Introductionmentioning

confidence: 99%

Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

Yuan

Hong

Zhang

et al. 2019

Cell Biology International

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Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments in clinic. Chrysophanol is a natural compound with multiple biological activities and protective roles in the cardiovascular system. However, its potential effect on cardiac hypertrophy remains unclear. In the current study, we found that chrysophanol could protect against isoproterenol (ISO)‐induced cardiac hypertrophy both in vitro and in vivo. Increase of cell surface and hypertrophic marker expression induced by ISO in neonatal rat cardiomyocytes was downregulated by chrysophanol. Moreover, chrysophanol ameliorated the abnormal changes of cardiac structure and function in rats subjected to ISO injection, as shown by echocardiography and morphometry measurements. Further mechanistical investigation demonstrated that chrysophanol inhibited phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) induced by ISO. Nuclear translocation of STAT3 and transcription of downstream genes promoted by ISO treatment were also remarkably suppressed by chrysophanol. Taken together, our findings revealed that chrysophanol attenuated ISO‐induced cardiac hypertrophy by inhibiting JAK2/STAT3 signaling pathway. Chrysophanol may be a potential candidate compound for the prevention and treatment of hypertrophy‐related cardiomyopathy.

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“…A paradox phenomenon has been found that the experiment showed Chrysophanol cannot penetrate the blood–brain barrier. However, it has the counter‐cerebral ischemia–reperfusion property (Chen, He, Xiong, & Li, ).…”

Section: Resultsmentioning

confidence: 99%

Rumex japonicusHoutt.: A phytochemical, pharmacological, and pharmacokinetic review

Sun

Lenon

Yang

2019

Phytotherapy Research

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Rumex japonicus Houtt. (RJH‐Yang Ti) RJH has been used as a folk medicine in East Asian countries for thousands of years. It has a wide range of therapeutic effects in terms of anti‐microorganic, anti‐oxidant, anti‐inflammatory, and antitumor effects. Therefore, it is urgent to thoroughly review the existing knowledge for this herb from phytochemical, pharmacological, and pharmacokinetic perspectives. “Yang Ti” and its English, botanical and pharmaceutical names used as keywords to perform database search which included the Encyclopaedia of traditional Chinese Medicines, PubMed, EMBASE, AMED, CINAHL, Cochrane Library, MEDLINE, Science Direct, Scopus, Web of Science, and China Network Knowledge Infrastructure. Forty‐five compounds identified from RJH. Besides, the therapeutic effects of RJH have been summarized as well. The root of RJH contains derivatives of anthraquinones, phytosterols, nepodin, oxanthrone c‐glycosides, phenolic acid, cinnamic acid, flavonoid, epoxynaphthoquinol, triterpenoids, methoxynaphthalene, trihydroxybenzene, anthracene‐9,10‐dione, and other compounds. The extract of RJH and its chemical compounds showed the potentials as a complementary agent to exert antioxidant, antimicrobial, antisepsis, anticancer, anti‐haematological disease, anti‐dermatological disease, and antidiabetic activities. For the record, there is no study conducted on RJH regarding its pharmacokinetic aspect. Notably, Emodin may require additional attention due to its multiple organ toxicity concerns.

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A novel GC–MS method for determination of chrysophanol in rat plasma and tissues: Application to the pharmacokinetics, tissue distribution and plasma protein binding studies

Cited by 24 publications

References 21 publications

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

Rumex japonicusHoutt.: A phytochemical, pharmacological, and pharmacokinetic review

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