A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel

Al-Sagur, H.; Komathi, S.; Khan, Maaz; Gürek, Ayşegül; Hassan, Aseel

doi:10.1016/j.bios.2016.10.038

Cited by 99 publications

(39 citation statements)

References 85 publications

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“…This interest is due to their tunable electrical conductivity that can be achieved through, facile polymerization, doping and their soft organic material properties [16]. They have important applications in electrochemical sensor and biosensor systems [17][18][19]. Conducting polymers are usually synthesized by chemical and electrochemical methods, mainly through oxidative polymerization.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Determination of Nicotine on PolyNiTSPc Electrodeposited Glassy Carbon Electrode: Investigation of Reaction Mechanism

Acar

Atun

2018

Electroanalysis

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In this paper, we report an electrochemical material for nicotine detection in aqueous solution by using glassy carbon electrode (GCE) electrodeposited with Nickel(II) phthalocyanine‐tetrasulfonic acid tetrasodium salt (polyNiTSPc) in Tetra n‐bütil ammonium hydroxide (TnBAH) alkaline solution. The detection performance of the polyNiTSPc/GCE and the reaction mechanism of nicotine electro‐oxidation process is investigated using Cyclic Voltammetry (CV) and Square Wave Voltammetry (SWV) techniques in 0.1 M phosphate buffer solution (pH 7.5). The conductivity properties of the bare GCE and polyNiTSPc/GCE were analysed using Electrochemical impedance spectroscopy (EIS). The surface morphology of bare GCE and polyNiTSPc/GCE are characterized by Atomic Force Microscopy (AFM). PolyNiTSPc shows high catalytic activity for the electro‐oxidation of nicotine, with the limit of detection at 146 nM nicotine. PolyNiTSPc/GCE can be used as a biosensor with very low detection limit for nicotine. Electrode process for nicotine oxidation is diffusion controlled, including irreversible one‐electron transfer attributed to the nicotine/nicotine‐Δ1′,(5′)‐iminium ion conversion on the polyNiTSPc coated electrode. Electrochemical measurements indicated that the polyNiTSPc against nicotine plays a similar role as CYP2A6 enzyme which catalyses the intermediate reaction product of nicotine‐cotinine transformation in most mammalian species.

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Section: Introductionmentioning

confidence: 99%

Sensitive Determination of Nicotine on PolyNiTSPc Electrodeposited Glassy Carbon Electrode: Investigation of Reaction Mechanism

Acar

Atun

2018

Electroanalysis

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“…Al‐Sagur et al. synthesized 3D robust matrix for the GOx immobilization through the reaction of multifunctional conducting polyacrylic acid (PAA) hydrogen (MFH) integrated with vinyl substituted polyaniline (VS‐PANI), reduced graphene oxide (rGO) and lutetium Phthalocyanine (LuPc 2 ). As seen in Figure A, the fabrication of PAA‐rGO/VS‐PANI/LuPc 2 /GOx‐MFH involves three steps.…”

Section: Preparation Of Graphene‐based Materials For Electrochemical mentioning

confidence: 99%

“…Meanwhile, Al‐Sagur et al. prepared LuPc 2 as redox mediator in rGO conducting polymer multifunction 3D matrix for the immobilization of GOx. The structural stability and hierarchical porosity of 3D matrix exhibited large surface area for anchoring GOx.…”

Section: Graphene‐based Materials For Glucose Sensorsmentioning

confidence: 99%

Graphene‐based Electrochemical Glucose Sensors: Fabrication and Sensing Properties

Zhang

Yang

et al. 2018

Electroanalysis

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With the increasing demand for highly sensitive and selective glucose sensors in industrial, clinical and pharmaceutical sectors, sensing materials for glucose detection have attracted much attention worldwide. Due to the large surface area, fascinating physical and electrochemical properties, graphene‐based materials have been widely used as a unique class of promising electrode materials in electrochemical sensing applications, with the continuously growing academic and technological developments. In this review, we summarize the different preparation strategies for the synthesis of graphene‐based materials and the application in electrochemical detection of glucose, including enzymatic and nonenzymatic glucose sensors.

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“…This can prevent the electrochemical reaction occurring between GOx and the transducer. In recent years, many studies have been performed to facilitate the electron transfer between the working electrode and the active center of GOx .…”

Section: Introductionmentioning

confidence: 99%

A Novel Enzymatic Glucose Biosensor and Nonenzymatic Hydrogen Peroxide Sensor Based on (3‐Aminopropyl) Triethoxysilane Functionalized Reduced Graphene Oxide

2017

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In the present study, a novel enzymatic glucose biosensor using glucose oxidase (GOx) immobilized into (3‐aminopropyl) triethoxysilane (APTES) functionalized reduced graphene oxide (rGO‐APTES) and hydrogen peroxide sensor based on rGO‐APTES modified glassy carbon (GC) electrode were fabricated. Nafion (Nf) was used as a protective membrane. For the characterization of the composites, Fourier transform infrared spectroscopy (FTIR), X‐ray powder diffractometer (XRD), and transmission electron microscopy (TEM) were used. The electrochemical properties of the modified electrodes were investigated using electrochemical impedance spectroscopy, cyclic voltammetry, and amperometry. The resulting Nf/rGO‐APTES/GOx/GC and Nf/rGO‐APTES/GC composites showed good electrocatalytical activity toward glucose and H2O2, respectively. The Nf/rGO‐APTES/GC electrode exhibited a linear range of H2O2 concentration from 0.05 to 15.25 mM with a detection limit (LOD) of 0.017 mM and sensitivity of 124.87 μA mM−1 cm−2. The Nf/rGO‐APTES/GOx/GC electrode showed a linear range of glucose from 0.02 to 4.340 mM with a LOD of 9 μM and sensitivity of 75.26 μA mM−1 cm−2. Also, the sensor and biosensor had notable selectivity, repeatability, reproducibility, and storage stability.

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A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel

Cited by 99 publications

References 85 publications

Sensitive Determination of Nicotine on PolyNiTSPc Electrodeposited Glassy Carbon Electrode: Investigation of Reaction Mechanism

Sensitive Determination of Nicotine on PolyNiTSPc Electrodeposited Glassy Carbon Electrode: Investigation of Reaction Mechanism

Graphene‐based Electrochemical Glucose Sensors: Fabrication and Sensing Properties

A Novel Enzymatic Glucose Biosensor and Nonenzymatic Hydrogen Peroxide Sensor Based on (3‐Aminopropyl) Triethoxysilane Functionalized Reduced Graphene Oxide

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