A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation

“…In order to assure the quality of R . HCl containing pharmaceutical formulations, several methods have been developed for its determination, including high-performance liquid chromatography (HPLC) [1][2][3][4][5][6] , high-performance thin-layer chromatography and scanning densitometry 7 , differential pulse polarography 8 , amperometry 9 , capillary electrophoresis 10 , conductometry 11 , coulometry 12 , voltammetry 13 , potentiometry 14 , fluorimetry 15 , chemiluminescence 16 , AAS 17 . The official method described in the United States Pharmacopeia 18 is based on potentiometric titration of R .…”

Section: Ranitidine N-(2-{[(5-dimethylamino)methyl]-2-furanyl}-methymentioning

confidence: 99%

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Moldovan¹,

Aboul‐Enein²

2012

J. Chil. Chem. Soc.

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A new spectrophotometric method has been developed for the determination of ranitidine hydrochloride (R . HCl) in bulk drug and in tablet formulation. The proposed method involves the addition of a measured excess of bromate-bromide reagent in hydrochloric acid medium to R . HCl, followed by determination of residual bromine by reacting with a fixed amount of Rhodamine B (RB) and measuring the absorbance at λ max =557 nm. Beer's law was found in the range of 0.3-3.2 μg ml -1 of R . HCl, with a good correlation coefficient (r=0.9997). The limits of detection and quantification were calculated to be 0.08 μg ml -1 and 0.24mg ml -1 , respectively. The different experimental parameters affecting the development and stability of the proposed method were carefully studied and optimized. The validity of the proposed method tested by analyzing the pure and pharmaceutical formulations and compared well with those obtained by the official method, demonstrated good accuracy and precision.

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“…In the literature, there are different methods for quantification of ranitidine using the following techniques: spectrophotometry [3][4][5][6][7][8][9][10][11], fluorimetry [7,12,13], chemiluminescence [14,15], spectrometry [16], electrochemistry [11,[17][18][19][20][21][22][23][24][25] and chromatography [26][27][28]. In most cases, using the methods of spectrophotometry, spectrometry, fluorimetry and chemiluminescence a preliminary step of derivatization is necessary, which will result in longer analysis times, an example of which is the precipitation of ranitidine with Co and Cd complex prior to analysis by spectrometry [16].…”

Section: Ranitidine (N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]-metmentioning

confidence: 99%

Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

Araújo

Paixão

2011

Electroanalysis

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A simple analytical method for ranitidine quantification was developed based on the electrocatalytic oxidation of ranitidine on a glassy carbon electrode modified by electrochemical deposition of ruthenium oxide hexacyanoferrate. Under optimal experimental conditions, the peak current response increases linearly with a ranitidine concentration over the range of 1.25-7.50 mmol L À1. The detection limit of the method was estimated to be 25 nmol L À1. The proposed method improves the analytical parameters obtained by other electroanalytical methods for the quantification of this drug, and it was employed for quantification of ranitidine in 3 commercial samples, the results being in agreement with those obtained by the manufactures.

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A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation

Cited by 56 publications

References 16 publications

Simultaneous Determination of NSAID and Antimicrobial Preservatives Using Validated RP-HPLC Method: An Application in Pharmaceutical and Clinical Laboratories

Simultaneous Determination of NSAID and Antimicrobial Preservatives Using Validated RP-HPLC Method: An Application in Pharmaceutical and Clinical Laboratories

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

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