A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation

Li, Jianlong; Dedloff, Margaret R.; Stevens, Katrina; Maney, Lea; Prochaska, Morgan; Hongay, Cintia F.; Wallace, Karen

doi:10.1016/j.ydbio.2019.08.005

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…43,44 The crypt depth reflects the activity and function of ISCs, and GCs dysfunction precedes the elongation of crypts. 45–47 The transcript levels of Muc2 in GD 18.5 fetal intestine from undernourished dams were reduced. 48 In this study, we found that the crypt depth of the fetal intestine was significantly shortened, and the number of GCs and the expression of Muc1 and Muc2 were reduced in the GDM group.…”

Section: Discussionmentioning

confidence: 99%

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Yang,

Cai,

Zhu

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Yang,

Cai,

Zhu

et al. 2023

Food Funct.

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Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution

Cha,

Hong,

Rai

et al. 2024

Funct Integr Genomics

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This article focuses on screening the major secreted proteins by the ischemia-challenged cardiac stromal fibroblasts (CF), the assessment of their expression status and functional role in the post-ischemic left ventricle (LV) and in the ischemia-challenged CF culture and to phenotype CF at single cell resolution based on the positivity of the identified mediators. The expression level of CRSP2, HSP27, IL-8, Cofilin-1, and HSP90 in the LV tissues following coronary artery bypass graft (CABG) and myocardial infarction (MI) and CF cells followed the screening profile derived from the MS/MS findings. The histology data unveiled ECM disorganization, inflammation and fibrosis reflecting the ischemic pathology. CRSP2, HSP27, and HSP90 were significantly upregulated in the LV-CABG tissues with a concomitant reduction ion LV-MI whereas Cofilin-1, IL8, Nrf2, and Troponin I were downregulated in LV-CABG and increased in LV-MI. Similar trends were exhibited by ischemic CF. Single cell transcriptomics revealed multiple sub-phenotypes of CF based on their respective upregulation of CRSP2, HSP27, IL-8, Cofilin-1, HSP90, Troponin I and Nrf2 unveiling pathological and pro-healing phenotypes. Further investigations regarding the underlying signaling mechanisms and validation of sub-populations would offer novel translational avenues for the management of cardiac diseases.

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Gut stem cells: Interplay with immune system, microbiota, and aging

Marotta¹,

Balakrishnan

Yazdani

et al. 2021

Stem Cells and Aging

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A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation

Cited by 4 publications

References 62 publications

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution

Gut stem cells: Interplay with immune system, microbiota, and aging

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