A novel handheld fluorescent microarray reader for point-of-care diagnostic

Kozma, P.; Lehmann, A.; Wunderlich, Kai; Michel, Dirk; Schumacher, Soeren; Ehrentreich‐Förster, Eva; Bier, Frank F.

doi:10.1016/j.bios.2013.03.043

Cited by 30 publications

(20 citation statements)

References 21 publications

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“…Sensitive and rapid measurement with point‐of‐care testing is often required in optical biosensor advancement. In view of this, hand‐held biosensor devices were developed using fluorometric technology for point‐of‐care diagnostics and aflatoxin detection (Carlson et al., ; Kozama et al., ). More recently, variety of smartphone‐biosensor platforms have been developed using imaging, absorbance, reflectance, fluorescence, SPR and localized SPR techniques which offer wide variety of diagnostic portable tools for disease diagnostics and to probe chemical experiments (Geng et al., ).…”

Section: Technological Innovation Of Biosensorsmentioning

confidence: 99%

Current technological trends in biosensors, nanoparticle devices and biolabels: Hi‐tech network sensing applications

Vigneshvar

Senthilkumaran

2018

Med Devices & Sens

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Biosensors are micro‐analytical devices usually coupled to a bio‐integrated transducer that emits signal to measure specific molecules as an analyte, either qualitatively or quantitatively for various downstream applications. Improved detection methods at quantum level in nanoscale became a reality due to the invention of integrated circuits involving nanoparticle devices and biolabels. Next level of discoveries leads to the identification of novel particulates to improve the specificity and sensitivity for single analyte detection. Although different kinds of biosensors show promise for multifaceted applications in science and technology, certain limitations do exist in terms of portability, selectivity and sensitivity as well as in multi‐analyte detection. Recent methodical advancements involving nanomaterials or nanoparticles/metals in combination with biomarkers or biolabels as sensors provide new insights to solve these limitations to prepare flawless detecting devices. These technical advances are evident in modern‐day sensors including hand‐held, smartphone‐based, wearable and flexible sensors developed for multifaceted applications. This concise review article describes the new technological trends in the development of biosensors integrated to nanoparticle devices and/or biolabels involving hi‐tech network system for better efficiency. Future perspectives on new technological developments for effective combination of several nanomaterials and biolabels with strategic engineering methodology were highlighted.

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Section: Technological Innovation Of Biosensorsmentioning

confidence: 99%

Current technological trends in biosensors, nanoparticle devices and biolabels: Hi‐tech network sensing applications

Vigneshvar

Senthilkumaran

2018

Med Devices & Sens

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“…In the handheld reader portMD-113 a planar waveguide is bearing the spots which are excited by the evanescent field of the guided light. Fluorescence signals are detected by portable low-cost device consisting of a pinhole array, a microlens array, an interference filter and a detector array [ 117 ].…”

Section: Automated Platformsmentioning

confidence: 99%

Analytical Protein Microarrays: Advancements Towards Clinical Applications

Sauer

2017

Sensors

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Protein microarrays represent a powerful technology with the potential to serve as tools for the detection of a broad range of analytes in numerous applications such as diagnostics, drug development, food safety, and environmental monitoring. Key features of analytical protein microarrays include high throughput and relatively low costs due to minimal reagent consumption, multiplexing, fast kinetics and hence measurements, and the possibility of functional integration. So far, especially fundamental studies in molecular and cell biology have been conducted using protein microarrays, while the potential for clinical, notably point-of-care applications is not yet fully utilized. The question arises what features have to be implemented and what improvements have to be made in order to fully exploit the technology. In the past we have identified various obstacles that have to be overcome in order to promote protein microarray technology in the diagnostic field. Issues that need significant improvement to make the technology more attractive for the diagnostic market are for instance: too low sensitivity and deficiency in reproducibility, inadequate analysis time, lack of high-quality antibodies and validated reagents, lack of automation and portable instruments, and cost of instruments necessary for chip production and read-out. The scope of the paper at hand is to review approaches to solve these problems.

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“…Moreover, many other highly-sensitive and accurate transducers (e.g. fluorescent, electrochemical, and mechanical sensors) require external readout instrumentation (Kozma et al, 2013;Gencoglu and Minerick, 2014;Cruz et al, 2014;Phillips and Lewis, 2013). For these applications, external power sources are critical to realizing the full benefits of POC diagnostics, and liquid handling components and bulky readout instrumentations must be miniaturized and integrated for handheld portable devices.…”

Section: Battery-powered Handheld Instrumentsmentioning

confidence: 99%

Powering point-of-care diagnostic devices

Choi

2016

Biotechnology Advances

107

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Effective and rapid point-of-care (POC) diagnostics have the capability to revolutionize public healthcare both in developed and developing countries. One of the key challenges that is critical to address in developing POC devices is to effectively and sufficiently power them. In developing countries, where the electricity grid is not well established and the use of batteries is not cost-effective, power supplies are the most problematic issue for stand-alone and self-sustained POC devices. In this review, we provide an overview of techniques for powering POC diagnostic devices for use in both developed and developing countries, as well as detailed discussions of recent advancements in POC devices. Then, we discuss next-generation POC diagnostics and their power source strategies.

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A novel handheld fluorescent microarray reader for point-of-care diagnostic

Cited by 30 publications

References 21 publications

Current technological trends in biosensors, nanoparticle devices and biolabels: Hi‐tech network sensing applications

Current technological trends in biosensors, nanoparticle devices and biolabels: Hi‐tech network sensing applications

Analytical Protein Microarrays: Advancements Towards Clinical Applications

Powering point-of-care diagnostic devices

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