A novel high mechanical and excellent hydrophilic electrospun polyurethane‐silk‐bioactive glass nanofiber film for rotator cuff injury repair

Abstract

Rotator cuff injury is the most common muscle injury in bone surgery and there was still enormously challenging to completely repair it. Disturbed by mechanical stability and biocompatibility, most implants have failed to relieve symptoms and prevent the development of osteoarthritis. Herein, we have firstly fabricated novel electrospinned nanofiber membranes by integrating the excellent mechanical properties of polyurethane (PU), the good biocompatibility of silk fibroin with the osteogenesis properties of bioactive glass (PSB). The obtained results have exhibited that the PSB nanofiber film possessed excellent mechanical properties with the tensile stress have reached 14.6 MPa and the tensile strain reached 70%, which had extremely remedied the properties of pure silk film (3.8 MPa and the tensile strain 7.9%). Especially, PSB has shown superior hydrophilicity (WCA) than silk (WCA) and PU (WCA) groups.Furthermore, we have endowed the PSB with osteogenesis by doping bioactive glass (BG) in it. The PSB film can long-term release functional ions (Si and B ions) that benefit bone tissue repair, and the CCK-8 and ALP results have also confirmed the excellent biocompatibility and osteogenesis of PSB. Hence, the novel PSB film may provide a new treatment strategy for repairing rotator cuff injury.

Progress on Electrospun Composite Fibers Incorporating Bioactive Glass: An Overview

“…Erbium and terbium co-doped BG particles (Er 3þ and/or Tb 3þ -doped 13-93 BG particles, size: 1.45-3.57 μm) were incorporated in PVA fibers in the investigation of Deliormanlı et al [80] Doping such ions did not inhibit the bioactivity of the BG and induced green luminescent behavior to BG, making the BG suitable for TE and bioimaging studies. Duan et al [81] fabricated electrospun fibers composed of polyurethane, SF, and BG (concentration: 0.4% (wt/vol)). Here the addition of BG led to excellent mechanical properties with tensile strength reaching 14.6 MPa (pure silk film: 3.8 MPa) and tensile strain reaching 70% (pure silk film: x, y = 0.35 or 0.00, and x 6 ¼ y), concentration: 10% (w/w), size: <45 μm) was incorporated in a PLLA electrospun membrane for bone TE application.…”