A novel, highly sensitive electrochemical 1,4-dioxane sensor based on reduced graphene oxide–curcumin nanocomposite

Fathima, T. K. Sana; A, Arshiya Banu; Thiyagarajan, Devasena; Ramaprabhu, Sundara

doi:10.1039/d2ra01789j

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…These peaks are suppressed and shifted in the spectra of the solution with both AgCNT and 25OHD, confirming a strong interaction between them. 34 Analytical parameters.-Reliability and stability.-Reliability and stability of the response are critical parameters to validate a sensor. The reliability of the response was assessed by comparing the ΔR values obtained consecutively (5 runs) in 100 nM 25OHD solution using AgCNT/GCE.…”

Section: Resultsmentioning

confidence: 99%

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃

Sana Fathima,

Ramaprabhu

2023

J. Electrochem. Soc.

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Vitamin D deficiency in the body is a worldwide health concern with major consequences on bone health. It is also related to cardiovascular diseases, depression, infectious diseases, autoimmune disorders, cancer, and recently even to COVID-19. In the present work, we have developed a silver-silver oxide nanoparticles-decorated carbon nanotube-modified glassy carbon electrode (AgCNT/GCE) based sensor for antibody-free, nanomolar detection of 25-hydroxyvitamin D (25OHD). The impedimetric technique was utilized to achieve high sensitivity. The sensor exhibited a linear response in the range of 20 to 100 nM. A remarkably low limit of detection of 7.9 nM was observed, which is lower than the deficiency level defined at 30 nM for human serum. The sensor exhibited excellent response stability, repeatability, reproducibility, and minimal interference. Excellent recovery of ~102 % was also observed in real serum samples. The sensing mechanism and the AgCNT-25OHD interaction have also been explored by electrochemical impedance spectroscopy, cyclic voltammetry, Fourier transform infrared spectroscopy, and UV-Vis spectroscopy.

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Section: Resultsmentioning

confidence: 99%

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃

Sana Fathima,

Ramaprabhu

2023

J. Electrochem. Soc.

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“…Sana et al 2022 developed a reduced graphene oxide-curcumin (rGO-CM) nanocomposite sensor for the electrochemical sensing of 1,4-dioxane. The rGO-CM sensor showed high sensitivity of 19.36 mA mM −1 cm −2 in the linear range 0.1 to 100 mM with 0.13 mM limit of detection (LOD) [34]. Iffath et al, 2023 reported the fabrication of a curcumin quantum dots (CMQD)-based electrochemical sensor for the ultrasensitive detection of dopamine.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Curcumin-Based Electrochemical Nanosensors for the Detection of Environmental Pollutants: 1,4-Dioxane and Hydrazine

Rasal,

Badsha,

Shellaiah

et al. 2024

Biosensors

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This work reports the development of novel curcuminoid-based electrochemical sensors for the detection of environmental pollutants from water. In this study, the first set of electrochemical experiments was carried out using curcumin-conjugated multi-walled carbon nanotubes (MWCNT–CM) for 1,4-dioxane detection. The MWCNT–CM/GCE showed good sensitivity (103.25 nA nM−1 cm−2 in the linear range 1 nM to 1 µM), with LOD of 35.71 pM and LOQ of 108.21 pM. The second set of electrochemical experiments was carried out with bisdemethoxy curcumin analog quantum dots (BDMCAQD) for hydrazine detection. The BDMCAQD/GCE exhibited good sensitivity (74.96 nA nM−1 cm−2 in the linear range 100 nM to 1 µM), with LOD of 10 nM and LOQ of 44.93 nM. Thus, this work will serve as a reference for the fabrication of metal-free electrochemical sensors using curcuminoids as the redox mediator for the enhanced detection of environmental pollutants.

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“…For this reason, curcumin was conjugated with GO and loaded into liposomes, which may improve the preformulation characteristics. , By combining both of them, they may show a synergistic response as antimicrobial. Liposomes have received a lot of interest in the topical drug delivery system because of their amphiphilic character, which makes them a superior penetration enhancer for the cutaneous route of administration than traditional formulations. − Therefore, the objectives of this work were to achieve better antimicrobial actions over the CUR-loaded liposomes. As a result, the primary goal of this work was complex (CUR + GO complex) development, and its characterization was investigated.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease

et al. 2022

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This study describes the development and characterization of curcumin with graphene oxide complex (CUR + GO) loaded into liposomes for treating skin disease. The developed complex was characterized by X-ray diffraction and showed a broad halo pattern, confirming the amorphous nature of the resulting complex. Furthermore, scanning electron microscopy revealed the irregular porous morphology of the complex-highlighting loss of the crystallinity and the emergence of the amorphous phase. Additionally, the liposomes showed long-term stability at 2–8 °C and 25 ± 2 °C/60 ± 5%RH with nonsignificant variations in the particle size, polydispersity index, and zeta potential. Overall, optical and high-resolution transmission electron microscopy images of liposomes showed a consistent shape, and no aggregation with uniform particle size distribution was observed. Furthermore, the cumulative drug release in the first 6 h was 71.24 and 64.24% for CUR-loaded liposomes and CUR-GO-loaded liposomes, respectively. The lower value of drug release might be attributed to the complex development. The drug release model found the first order with non-Fickian diffusion process, which is often observed at higher n > 0.5. The antibacterial activity of the CUR with GO-loaded liposome (D2) offered higher anti-microbial activity over other formulations against the mentioned bacterial microorganism that causes skin diseases.

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A novel, highly sensitive electrochemical 1,4-dioxane sensor based on reduced graphene oxide–curcumin nanocomposite

Abstract: Reduced graphene oxide–curcumin (rGO–CM) nanocomposite was prepared from graphite oxide using curcumin. The rGO–CM/GCE was used for highly sensitive 1,4-dioxane detection. The LOD obtained (0.13 μM) was lower than the WHO guideline value.

Cited by 8 publications

References 25 publications

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃

Fabrication of Curcumin-Based Electrochemical Nanosensors for the Detection of Environmental Pollutants: 1,4-Dioxane and Hydrazine

Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease

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A novel, highly sensitive electrochemical 1,4-dioxane sensor based on reduced graphene oxide–curcumin nanocomposite

Abstract: Reduced graphene oxide–curcumin (rGO–CM) nanocomposite was prepared from graphite oxide using curcumin. The rGO–CM/GCE was used for highly sensitive 1,4-dioxane detection. The LOD obtained (0.13 μM) was lower than the WHO guideline value.

Cited by 8 publications

References 25 publications

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D3

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D3

Fabrication of Curcumin-Based Electrochemical Nanosensors for the Detection of Environmental Pollutants: 1,4-Dioxane and Hydrazine

Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease

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An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃

An Antibody-Free, Silver-Silver Oxide-Carbon Nanotube Nanocomposite-Based Impedimetric Sensor for the Nanomolar Detection of 25-Hydroxyvitamin D₃