A novel hybrid fluorescence probe sensor based on metal–organic framework@carbon quantum dots for the highly selective detection of 6-mercaptopurine

Mousavi, Aida; Zare‐Dorabei, Rouholah; Mosavi, Seyed Hossein

doi:10.1039/d0ay01592j

Cited by 45 publications

(17 citation statements)

References 50 publications

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“…6-Mercaptopurine (6-MP) is one of the anticancer drugs used to treat acute lymphocytic leukemia, a type of cancer of the blood and bone marrow. Acute lymphocytic leukemia is one of the most common cancers in children. ,, Nevertheless, its medical use has been limited by side effects such as oligospermia, renal toxicity, bone marrow suppression, granulocytopenia, and lymphocytopenia . More effective treatment should be used to reduce the side effects and improve the efficacy. , For this reason, the use of smart medicine is now being considered.…”

Section: Introductionmentioning

confidence: 99%

“…Acute lymphocytic leukemia is one of the most common cancers in children. 4,24,25 Nevertheless, its medical use has been limited by side effects such as oligospermia, renal toxicity, bone marrow suppression, granulocytopenia, and lymphocytopenia. 26 More effective treatment should be used to reduce the side effects and improve the efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of NMOF-5 Using Microwave and Coating with Chitosan: A Smart Biocompatible pH-Responsive Nanocarrier for 6-Mercaptopurine Release on MCF-7 Cell Lines

Mosavi

Zare‐Dorabei

2022

ACS Biomater. Sci. Eng.

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Cancer is one of the most difficult diseases to treat, threatening the lives of millions of people today. So far, various methods have been used to treat cancer, each having its drawbacks. One of these methods is treatment with anticancer drugs, which unfortunately have severe side effects. One of the causes of these complications is the nonspecific effects of anticancer drugs, which attack normal cells in addition to cancer cells and damage healthy tissues. In this study, we are trying to reduce the side effects and increase the efficacy of the drug by providing smart drug delivery. The metal−organic framework (MOF) was rapidly synthesized using a microwave method and at the nanoscale. The particle size of NMOF-5 was 18−20 nm, and its surface area was 2690 m 2 •g −1 . A chitosan polymer coating was formed on the nanocarrier after 6mercaptopurine was introduced. The biocompatible nanocarrier exhibited a high capacity to adsorb the drug. The biocompatible nanocarrier slowly and uniformly released 96.78% of the drug in a simulated solution at pH 5 and 20.52% at pH 7.4. This showed that CS-6-MP-NMOF-5 released the drug smartly and pH-sensitively. The stability of the biocompatible nanocarrier was studied at different pH values and remained stable at pH 5 for up to 48 h. The toxicity study of the MCF-7 cell line at different concentrations for 24 h showed the excellent performance of the biocompatible nanocarrier compared to the free drug in terms of toxicity to breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of NMOF-5 Using Microwave and Coating with Chitosan: A Smart Biocompatible pH-Responsive Nanocarrier for 6-Mercaptopurine Release on MCF-7 Cell Lines

Mosavi

Zare‐Dorabei

2022

ACS Biomater. Sci. Eng.

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“…Shuang’s group designed an anthraquinone–imidazole-based colorimetric and fluorescent sensor for the analysis of Ag(I) and thiols . Zare-Dorabei’s groups synthesized diphenylthiocarbazone immobilized on the triacetyl cellulose membrane, a nanocomposite containing silver sulfide QDs and graphitic carbon nitride nanosheets (g-C 3 N 4 NNs), and a series of nanomaterials to detect Ag(I), small biological molecules, and other hazardous substances. − Liao’s group prepared the g-C 3 N 4 NNs/polyacrylamide/polyacrylic acid composite hydrogel by using the radical polymerization method, which can act as a fluorescent probe to detect Ag(I) with a limit of detection (LOD) of 6.31 μmol L –1 . Chen’s group synthesized the acetaldehyde-modified g-C 3 N 4 NNs through the ethylene glycol-assisted liquid exfoliation method, which was successfully used to detect Ag(I) based on the photo-induced electron transfer (PET) .…”

Section: Introductionmentioning

confidence: 99%

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Guo

Yang

Wei

et al. 2022

ACS Appl. Nano Mater.

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Graphitic carbon nitride quantum dots (g-C 3 N 4 QDs) are synthesized using a simple, one-pot, and methylamine-assisted hydrothermal method. This material with excellent fluorescence property can be contracted in dual-mode fluorescence switching platforms for trace analysis of Ag(I) and cysteine. Upon adding Ag(I), the fluorescence intensity of g-C 3 N 4 QDs is quenched quickly, but its fluorescence resonance light scattering (RLS) intensity increases owing to the synergistic mechanism between photoinduced electron transfer and chelation mechanisms. Upon subsequently adding cysteine, the fluorescence intensity of g-C 3 N 4 QDs recovers rapidly; however, its RLS intensity decreases obviously due to the strong binding ability between Ag(I) and thiols. According to this interesting reaction mechanism, an "on−off−on" and "off−on−off" dual-mode fluorescence switching sensor exhibits high selectivity and sensitivity for simultaneously analyzing Ag(I) and cysteine, and the detection limits are calculated to be 8.0 and 10.3 nmol L −1 , respectively. The present study also displays excellent analytical performance for the analysis of Ag(I) and cysteine in natural samples.

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“…In this phenomenon, Cr(III) would absorb the emission light of S-CDs, but the excitation light would be constant since the addition of Cr(III) into the S-CDs solution. Therefore, the emission PL intensity of S-CDSs would be a turn-off (Shahbazi and Zare-Dorabei 2019;Mousavi et al 2020). Figure 6b shows no difference in absorption spectrum S-CDs both in absence Cr(III) and presence Cr(III).…”

Section: Possible Mechanism Of Cr(iii) Detectionmentioning

confidence: 93%

Sulfur-doped carbon dots synthesis under microwave irradiation as turn-off fluorescent sensor for Cr(III)

et al. 2021

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This study synthesized a facile and high sensitive fluorescent probe based on sulfur-doped carbon dots (S-CDs) using a one-step microwave irradiation method. The probe exhibited a strong blue emission and a high quantum yield (QY) of 36.40%. In the detection, the presence of trivalent chromium (Cr(III)) strongly quenched the PL intensity of S-CDs by the inner filter effect (IFE) quenching mechanism of Cr(III) on the S-CDs. The S-CDs exhibited good sensitivity to turn-off Cr(III) detection with a linear range concentration of 0–45 μM and a detection limit of 0.17 μM. Furthermore, the proposed method has been successfully applied for Cr(III) detection in natural water samples with the 93.68–106.20% recoveries.

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A novel hybrid fluorescence probe sensor based on metal–organic framework@carbon quantum dots for the highly selective detection of 6-mercaptopurine

Abstract: In this present study, MIL-101(Fe) and amine-carbon quantum dots (CQDs) were combined by means of a post-synthetic modification (PSM) method, thus a novel MIL-101(Fe)@amine-CQDs hybrid fluorescent probe sensor for detection...

Cited by 45 publications

References 50 publications

Synthesis of NMOF-5 Using Microwave and Coating with Chitosan: A Smart Biocompatible pH-Responsive Nanocarrier for 6-Mercaptopurine Release on MCF-7 Cell Lines

Synthesis of NMOF-5 Using Microwave and Coating with Chitosan: A Smart Biocompatible pH-Responsive Nanocarrier for 6-Mercaptopurine Release on MCF-7 Cell Lines

Graphitic Carbon Nitride Quantum Dots in Dual-Mode Fluorescence Switching Platforms for Trace Analysis of Ag(I) and l-Cysteine

Sulfur-doped carbon dots synthesis under microwave irradiation as turn-off fluorescent sensor for Cr(III)

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