A novel image analysis approach for evaluation of mixing uniformity in drug-filled silicone rubber matrix

Karami, Samaneh; Imani, Mohammad; Farahmandghavi, Farhid

doi:10.1016/j.ijpharm.2013.10.002

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…Installing a drug-release character to any PDMS materials has also been carried out by directly dispersing drug molecules into a polymeric matrix. 20,21 Nevertheless, this direct mixing method is only popular in pharmaceutical preparations and devices, such as a silicone elastomer vaginal gel with antiviral activity, 22 intravaginal drug-delivery rings, 23−25 and transdermal drug-delivery patches, 26 in which the mechanical properties and long-term stability of the devices are not critical. To conserve the mechanical and viscoelastic properties of PDMS medical devices, only limited amounts of drugs could be mixed into the polymeric matrix; thus, the release of sufficient amounts of drugs could not be attained through this strategy.…”

Section: ■ Introductionmentioning

confidence: 99%

Silicone Surface with Drug Nanodepots for Medical Devices

Mokkaphan

Banlunara

Palaga

et al. 2014

ACS Appl. Mater. Interfaces

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An ideal surface of poly(dimethylsiloxane) (PDMS) medical devices requires sustained drug release to combat various tissue responses and infection. At present, a noncovalent surface coating with drug molecules using binders possesses a detachment problem, while covalently linking drug molecules to the surface provides no releasable drug. Here, a platform that allows the deposition of diverse drugs onto the PDMS surface in an adequate quantity with reliable attachment and a sustained-release character is demonstrated. First, a PDMS surface with carboxyl functionality (PDMS-COOH) is generated by subjecting a PDMS piece to an oxygen plasma treatment to obtain silanol moieties on its surface, then condensing the silanols with (3-aminopropyl)triethoxysilane molecules to generate amino groups, and finally reacting the amino groups with succinic anhydride. The drug-loaded carriers with hydroxyl groups on their surface can then be esterified to PDMS-COOH, resulting in a PDMS surface covalently grafted with drug-filled nanocarriers so that the drugs inside the securely grafted carriers can be released. Demonstrated here is the covalent linking of the surface of a PDMS endotracheal tube with budesonide-loaded ethylcellulose nanoparticles. A secure and high drug accumulation at the surface of the tubes (0.025 mg/cm2) can be achieved without changes in its bulk property such as hardness (Shore-A), and sustained release of budesonide with a high release flux during the first week followed by a reduced release flux over the subsequent 3 weeks can be obtained. In addition, the grafted tube possesses more hydrophilic surface and thus is more tissue-compatible. The grafted PDMS pieces show a reduced in vitro inflammation in cell culture and a lower level of in vivo tissue responses, including a reduced level of inflammation, compared to the unmodified PDMS pieces, when implanted in rats. Although demonstrated with budesonide and a PDMS endotracheal tube, this platform of grafting a PDMS surface with drug-loaded particles can be applied to other drugs and other devices.

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Section: ■ Introductionmentioning

confidence: 99%

Silicone Surface with Drug Nanodepots for Medical Devices

Mokkaphan

Banlunara

Palaga

et al. 2014

ACS Appl. Mater. Interfaces

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“…The subject of inhomogeneity of drug and binder across different size has received a lot of attention in literature [13,16,[26][27][28][29][30][31]. Several possible causes of drug inhomogeneity have been discussed namely difference in the particle sizes of constituents, different in solubility [32] and migration of the drug particles [33].…”

Section: Mb Distributionmentioning

confidence: 99%

Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

Mangwandi¹,

Zainal

Liu³

et al. 2015

Powder Technology

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Publisher rights This is the author's version of a work that was accepted for publication in Powder Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Powder Technology, vol 272, issue March 2015 doi: 10.1016/j.powtec.2014.11.042. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. The overall aim of the project was to study the influence of process variables on the 36 distribution of a model active pharmaceutical ingredient (API) during fluidised melt 37 granulation of pharmaceutical granules with a view of optimising product characteristics. 38Granules were produced using common pharmaceutical excipients; lactose monohydrate 39 using poly ethylene glycol (PEG1500) as a meltable binder. Methylene blue was used as a

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“…Moreover, accurate characterization of fields uniformity is essential for the optimization of velocity field [9,10,11], electric fields [12,13], magnetic fields [14,15], etc.. A large number of mathematical works have been devoted to studying this issue. In practice, characterizing the mixing distribution of these flow patterns quantitatively using image processing technology, which has been effectively used for feature extraction in medical, bioengineering [16], pharmaceutics [17] and chemical industries, has drawn considerable interest in recent years. Aubin et al (2010) reviewed existing methods for the characterisation of mixing and flow in microchannels, micromixers and microreactors [18].…”

Section: Introductionmentioning

confidence: 99%

Measure of bubble non-uniformity within circular region in a direct-contact heat exchanger

Xiao

Pan

et al. 2017

International Journal of Heat and Mass Transfer

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The study of bubble swarm distributions in a direct-contact heat exchanger was addressed both theoretically and experimentally. But recently developed approach based on uniform design for measuring bubbles uniformity and mixing efficiency within rectangular or square region can not be used to characterise the mixture homogeneity and mixing time within circular region. This paper discussed the difference between rectangular or square region and circular region. A quantitative metric of mixing uniformity is used to characterize the bubble patterns within circular region. Simulation studies are also used to illustrate the proposed methodologies while the experimental case considered demonstrate that the proposed approach evaluated the experimental data rather well. The space-time features of the mixing transient have been successfully derived when the bubble swarms or other objects distribute in a circular region. This work brings new insights to evaluate mixing quality of different systems practically, which has a high degree of accuracy (the percentage of enhancing achieved is about 40%).

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A novel image analysis approach for evaluation of mixing uniformity in drug-filled silicone rubber matrix

Cited by 12 publications

References 23 publications

Silicone Surface with Drug Nanodepots for Medical Devices

Silicone Surface with Drug Nanodepots for Medical Devices

Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

Measure of bubble non-uniformity within circular region in a direct-contact heat exchanger

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