A novel imaging beta probe for radio-guided surgery

Thacker, Samta; Stack, Brendan C.; Lowe, Val J.; Gaysinskiy, V.; Cool, Steven; Nagarkar, Vivek V.; Entine, G.

doi:10.1109/nssmic.2008.4774128

Cited by 5 publications

(9 citation statements)

References 5 publications

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“…We were also able to acquire an image of the underlying 90 Sr source, even with the protective latex sleeve and 4 layers of chicken skin between the source and the IBP, further demonstrating the high sensitivity of the probe. 6 …”

Section: Resultsmentioning

confidence: 99%

“…6 Due to its high density and high average atomic number the CsI:Tl film, while only ~140 μm thick, completely absorbed and enabled the detection of every incident beta particle, while being highly insensitive to gamma background. Further, the high light output of CsI:Tl (56,000 ph/MeV) and high sensitivity of the EMCCD photodetector increased overall IBP sensitivity and effectiveness, by detecting low-energy incident betas from a 3 H source.…”

Section: Discussionmentioning

confidence: 99%

“…6, 7 In addition, ultra-thin scintillators with high sensitivity for such betas have correspondingly low sensitivity to gammas. This allows them to be used around background gamma irradiation without interference, such as in 18 FDG cases.…”

Section: Introductionmentioning

confidence: 99%

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A hand-held beta imaging probe for FDG

et al. 2012

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Objectives Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. Methods We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDG-avid primary tumors and metastases in an animal model. Results We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model. Conclusions It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A hand-held beta imaging probe for FDG

et al. 2012

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“…At present, most such probes are non-imaging, and provide no ancillary information of surveyed areas, such as clear delineations of malignant tissues. These probes are usually gamma-sensitive, and are used in conjunction with radiopharmaceuticals such as 18 FDG,99m Tc, 131 I, 111 In, or 125 I [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. However, the gamma-sensitive probes are not capable of distinguishing between the signals originating from contacting tissue and signals from surrounding tissues and background gamma radiation.…”

Section: Introductionmentioning

confidence: 99%

“…An alternative approach in the design of surgical probes with higher spatial accuracy is to make the detector selectively sensitive to short-range radiation, such as beta rays. RMD has previously designed such probe using EMCCD camera and microcolumnar CsI:Tl as the scintillator [18][19]. While the structured scintillator used in the design provides high spatial resolution, the detector lacked a sensor to effectively eliminate the strong gamma background signal.…”

Section: Introductionmentioning

confidence: 99%

A novel intra-operative positron imager for rapid localization of tumor margins

2014

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Imaging skins: stretchable and conformable on-organ beta particle detectors for radioguided surgery

et al. 2023

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While radioguided surgery traditionally relied on detecting gamma rays, direct detection of beta particles could facilitate the detection of tumour margins intraoperatively by reducing radiation noise emanating from distant organs, thereby improving the signal-to-noise ratio (SNR) of the imaging technique. In addition, most existing beta detectors do not offer surface sensing or imaging capabilities.Therefore, in this article, we explore the concept of a stretchable scintillator to detect beta-particles emitting radiotracers that would be directly deployed on the targetted organ. Such detectors, which we refer to as imaging skins, would work as indirect radiation detectors made of light-emitting agents and biocompatible stretchable material. Our vision is to detect scintillation using standard endoscopes routinely employed in minimally invasive surgery (MIS). Moreover, surgical robotic systems would ideally be used to apply the imaging skins, allowing for precise control of each component, thereby improving positioning and task repeatability. While still in the exploratory stages, this innovative approach has the potential to improve the detection of tumour margins during radioguided surgery by enabling real-time imaging, ultimately improving surgical outcomes.

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A novel imaging beta probe for radio-guided surgery

Cited by 5 publications

References 5 publications

A hand-held beta imaging probe for FDG

A hand-held beta imaging probe for FDG

A novel intra-operative positron imager for rapid localization of tumor margins

Imaging skins: stretchable and conformable on-organ beta particle detectors for radioguided surgery

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