2022
DOI: 10.3389/fgene.2022.921902
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A novel immune-related radioresistant lncRNAs signature based model for risk stratification and prognosis prediction in esophageal squamous cell carcinoma

Abstract: Background and purpose: Radioresistance remains a major reason of radiotherapeutic failure in esophageal squamous cell carcinoma (ESCC). Our study is to screen the immune-related long non-coding RNA (ir-lncRNAs) of radiation-resistant ESCC (rr-ESCC) via Gene Expression Omnibus (GEO) database and to construct a prognostic risk model.Methods: Microarray data (GSE45670) related to radioresistance of ESCC was downloaded from GEO. Based on pathologic responses after chemoradiotherapy, patients were divided into a n… Show more

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Cited by 3 publications
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“…GEO datasets have been increasingly used as advanced and convenient tools for the quick screening of candidate genes related to specific biological processes including radioresistance in cancer [ 29 31 ]. In this study, by analyzing GSE31863 and GSE101920 datasets and querying TCGA-BRCA database, we obtained UBE3C as an upregulated gene in BRCA tissue samples following radioresistance and its elevation was linked to poor radioresponse.…”
Section: Discussionmentioning
confidence: 99%
“…GEO datasets have been increasingly used as advanced and convenient tools for the quick screening of candidate genes related to specific biological processes including radioresistance in cancer [ 29 31 ]. In this study, by analyzing GSE31863 and GSE101920 datasets and querying TCGA-BRCA database, we obtained UBE3C as an upregulated gene in BRCA tissue samples following radioresistance and its elevation was linked to poor radioresponse.…”
Section: Discussionmentioning
confidence: 99%