A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro

Tang, Francesca; Hansbro, Philip M.; Burgess, Janette K.; Ammit, Alaina J.; Baines, Katherine J.; Oliver, Brian G.

doi:10.1136/thoraxjnl-2015-207781

Cited by 27 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45 Neutrophils are antiinfective and have recently been found to have modulatory functions. 46 In COPD, neutrophils are intrinsically altered with abnormal host defence functions and have unusual chemotactic behaviour and migratory structure. 47 Activated neutrophils cause lung destruction and emphysematous change through the release of oxygen radicals and proteolytic enzymes, including NE that reduces ciliary function, induces epithelial damage and is a potent stimulator of mucin production.…”

Section: Role In Copd Pathogenesismentioning

confidence: 99%

“…191 Importantly, these and other models have increased susceptibility to respiratory bacterial and viral infections that are relevant to those in humans described above. 8,9,46 They are being used to assess the mechanisms of the associations between infections, microbiomes and COPD and have recently implicated roles for immune defects, microRNAs, mast cell proteases and many other factors. In combination with parallel ex vivo human sample and primary cell culture analysis, they provide powerful tools for exploring these associations and are valuable for testing new drugs.…”

Section: Utility Of Mouse Models and New Translational Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

et al. 2017

View full text Add to dashboard Cite

COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD pathogens such as Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae are strongly associated with acute exacerbations of COPD (AECOPD), the clinical relevance of these pathogens in stable COPD patients remains unclear. Immune responses in stable and colonized COPD patients are comparable to those detected in AECOPD, supporting a role for chronic colonization in COPD pathogenesis through perpetuation of deleterious immune responses. Advances in molecular diagnostics and metagenomics now allow the assessment of microbe-COPD interactions with unprecedented personalization and precision, revealing changes in microbiota associated with the COPD disease state. As microbial changes associated with AECOPD, disease severity and therapeutic intervention become apparent, a renewed focus has been placed on the microbiology of COPD and the characterization of the lung microbiome in both its acute and chronic states. Characterization of bacterial, viral and fungal microbiota as part of the lung microbiome has the potential to reveal previously unrecognized prognostic markers of COPD that predict disease outcome or infection susceptibility. Addressing such knowledge gaps will ultimately lead to a more complete understanding of the microbe-host interplay in COPD. This will permit clearer distinctions between acute and chronic infections and more granular patient stratification that will enable better management of these features and of COPD.

show abstract

Section: Role In Copd Pathogenesismentioning

confidence: 99%

Section: Utility Of Mouse Models and New Translational Techniquesmentioning

confidence: 99%

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

et al. 2017

View full text Add to dashboard Cite

show abstract

“…They are therefore likely to be valuable in facilitating the evaluation of relationships between microbiota, health and disease. These can be combined with ex vivo studies using primary cells from humans, including with microbial challenge …”

Section: Future Perspectives Of the Microbiomementioning

confidence: 99%

“…These can be combined with ex vivo studies using primary cells from humans, 119 including with microbial challenge. [129][130][131] How to best translate findings into clinical care practice and bedside application?…”

Section: Elucidating Relationships Between Microbiomes and Health Andmentioning

confidence: 99%

Microbiomes in respiratory health and disease: An Asia‐Pacific perspective

et al. 2017

View full text Add to dashboard Cite

There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas.

show abstract

“…Viral infection of the respiratory tract may precede bacterial infection or be associated with bacterial dysbiosis, and therefore respiratory viruses could have a role in driving bacterial exacerbations . Furthermore, viral respiratory tract infection in itself can drive neutrophilic inflammation and might therefore contribute to progressive bronchiectasis. Consequently, whether positive viral swabs should instruct antibiotic cessation is unclear and has not yet been recommended, with other measures such as sputum purulence being a better marker of rapid response to antibiotics .…”

Section: Respiratory Virusesmentioning

confidence: 99%

Viral infection in primary antibody deficiency syndromes

Jones

Buckland

Breuer

et al. 2019

Reviews in Medical Virology

View full text Add to dashboard Cite

Patients with primary antibody deficiency syndromes such as X-linked agammaglobulinemia (XLA) and common variable immunodeficiency (CVID) are at increased risk of severe and invasive infection. Viral infection in these populations has been of increasing interest as evidence mounts that viruses contribute significant morbidity and mortality: this is mediated both directly and via aberrant immune responses.We explain the importance of the humoral immune system in defence against viral pathogens before highlighting several significant viral syndromes in patients with antibody deficiency.We explore historical cases of hepatitis C via contaminated immunoglobulin products, the predisposition to invasive enteroviral infections, prolonged excretion of vaccinederived poliovirus, the morbidity of chronic norovirus infection, and recent literature revealing the importance of respiratory viral infections. We discuss evidence that herpesviruses may play a role in driving the inflammatory disease seen in a subset of patients. We explore the phenomenon of within-host evolution during chronic viral infection and the potential emergence of new pathogenic strains. We highlight novel and emerging viruses identified via deep sequencing techniques. We describe the treatment strategies that have been attempted in all these scenarios and the urgent outstanding questions for research.

show abstract

A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro

Cited by 27 publications

References 48 publications

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

Microbiomes in respiratory health and disease: An Asia‐Pacific perspective

Viral infection in primary antibody deficiency syndromes

Contact Info

Product

Resources

About