A novel ingestible electronic drug delivery and monitoring device

Schaar, Peter; Dijksman, Joshua; Gast, Henny Broekhuizen-de; Shimizu, Jeff; Lelyveld, Niels van; Zou, Hans; Iordanov, V.P.; Wanke, Christoph; Siersema, Peter D.

doi:10.1016/j.gie.2013.03.170

Cited by 99 publications

(75 citation statements)

References 20 publications

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“…It can be programmed to release a drug either continuously or as a bolus by a miniaturized pump (Becker et al, 2014;van der Schaar et al, 2013). The system consists of a body and a cap (Figure 19).…”

Section: Telemetrymentioning

confidence: 99%

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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(2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39960/1/FinalVersion-Revised-FOR_EPRINTS_1_YEAR_EMBARGO_ELSEVIER.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. After oral intake, a drug formulation is challenged by several gastrointestinal (GI) barriers. Complex variables such as pH, GI secretions and GI transit/motility along the GI tract can affect drug release and absorption in a positive or negative way depending on the physicochemical properties of the drug compound (e.g. pH/pKa interplay for ionizable drugs) and/or the formulation characteristics (e.g. pHsensitive coating). In addition, inter-subject variability in characteristics of the GI environment may cause variable drug absorption and systemic drug availability (Riethorst et al., 2015). Determining the median and range for specific GI variables, and understanding how they influence oral drug behavior along the GI tract, will be helpful in the field of drug development. 2The present review provides an overview of different methodologies that can be applied to study physiological variables of the human GI tract and their impact on oral drug absorption in healthy and patient populations. The methodologies have been subdivided into two groups: (i) noninvasive and (ii) invasive methodologies. Although some of the methodologies are more historical than operational, they have been of paramount importance for innovations in drug and formulation development; in addition, they have created the basis for several novel methodologies, leading to an in-depth comprehension of different GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and GI pH (intraluminal sampling and telemetry). Noninvasive methodologiesa. Scintigraphy Disturbances in the normal movement of food along the GI tract can be associated with abdominal pain, early satiety and nausea. Measurement of GI transit, es...

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Section: Telemetrymentioning

confidence: 99%

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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“…Thanks to recent advances in ingestible electronics, it is now possible to perform video capture 1 , electronically-controlled drug release 2 , pH, temperature, and pressure recording 3 , and heart rate and respiration monitoring 4 , all from within electronic pill-like capsules placed in the gastrointestinal (GI) tract. Recent progress in energy harvesting and wireless power transfer is offering new options to power these devices, but many are not well suited to ingestible capsules.…”

mentioning

confidence: 99%

Prolonged energy harvesting for ingestible devices

et al. 2017

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Ingestible electronics have revolutionized the standard of care for a variety of health conditions. Extending the capacity and safety of these devices, and reducing the costs of powering them, could enable broad deployment of prolonged monitoring systems for patients. Although prior biocompatible power harvesting systems for in vivo use have demonstrated short minute-long bursts of power from the stomach, not much is known about the capacity to power electronics in the longer term and throughout the gastrointestinal tract. Here, we report the design and operation of an energy-harvesting galvanic cell for continuous in vivo temperature sensing and wireless communication. The device delivered an average power of 0.23 μW per mm2 of electrode area for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs. This power-harvesting cell has the capacity to provide power for prolonged periods of time to the next generation of ingestible electronic devices located in the gastrointestinal tract.

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“…The availability of a controllable Drug Delivery Systems (DDS) may reduce toxicity associated with systemic administration and prevent the formation of antibodies to drugs, particularly in the case of colon cancer or inflammatory bowel disease therapies [13]. These are two extremely common diseases, with colorectal cancer being the second leading cause of cancer-related deaths in USA [14], while Crohns disease and ulcerative colitis -both inflammatory bowel diseases -being diagnosed in 201 and 238 per 100,000 people in the USA, respectively.…”

Section: Clinical Motivation For Drug Delivery Systemsmentioning

confidence: 99%

Component based design of a drug delivery capsule robot

Beccani

Aiello

Gkotsis

et al. 2016

Sensors and Actuators A: Physical

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Since the introduction of Wireless Capsule Endoscopy (WCE) researchers have started exploring the design space of Medical Capsule Robots (MCRs): embedded micro-systems that can operate autonomously within the human body and can diagnose, prevent, monitor, and cure diseases. Although the research in the area of MCRs is an active topic and has grown exponentially, current devices provide only limited functionalities because their design process is expensive and time consuming. To open this research field to a wider community and, at the same time, create better designs through advanced tool support, in our previous works we presented a design environment for the rapid development of MCRs. In this paper, this environment was adopted to design a Drug Delivery Capsule (DDC) based on a coil-magnetpiston mechanism. The force of the coil acting on the magnetic piston and the drug release profile were modeled and assessed on bench-top with a maximum relative error below 5%. Then, in vivo trials were performed to validate the DDC functionality with a scheduled drug release profile for a 5 hours and 24 minutes procedure. The resulting design environment template is available open source for further development of drug delivery applications as well as to serve as guideline in prototyping novel MCRs addressing other clinical needs.

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A novel ingestible electronic drug delivery and monitoring device

Cited by 99 publications

References 20 publications

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Prolonged energy harvesting for ingestible devices

Component based design of a drug delivery capsule robot

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