A novel ionic liquid based electrochemical sensor for detection of pyrazinamide

Chokkareddy, Rajasekhar; Thondavada, Niranjan; Kabane, Bakusele; Redhi, Gan G.

doi:10.1007/s13738-020-02047-1

Cited by 18 publications

(9 citation statements)

References 40 publications

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“…Through the Randles–Sevick equation (Chokkareddy et al., 2020; Garcia‐Miranda Ferrari et al., 2018; Kilele et al., 2020):

I_{pa} = 2 . 69 \times 1 0^{5} A C n^{3 / 2} {D_{R}}^{1 / 2} {normalv}^{1 / 2}

where I pa is the peak current of the anode, A is the surface area of the electrode, n is the number of transferred electrons, C is the concentration of the detection solution, D R is the diffusion coefficient, and v is the scan rate. The results show that the surface area of the working electrode is 27.29 mm 2 , while that of the bare electrode is 7.068 mm 2 , which indicates that the RPC immobilized on the electrode surface can effectively promote the rapid transfer of electrons on the electrode surface (Rajasekhar Chokkareddy et al., 2020), and obtain a higher peak current (Figure 4) than that of the bare electrode.…”

Section: Resultsmentioning

confidence: 96%

Penicillin biosensor based on rhombus‐shaped porous carbon/hematoxylin/penicillinase

Wang

Xiu

et al. 2021

Journal of Food Science

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In this experiment, we designed an electrochemical sensor using penicillinase (Pen X)-rhombus porous carbon (RPC) as the detection element and hematoxylin as the indicator to detect low concentrations of penicillin sodium (Pen G). A differential pulse voltammetry (DPV) method was used to detect Pen G in the concentration range of 10 -8 -10 -5 mg⋅mL -1 under optimal experimental conditions. The results showed that the peak current value and the logarithm of Pen G concentration showed a good linear relationship (R 2 = 0.9915), and the LOD was 2.68 × 10 -7 mg⋅mL -1 (S/N = 3). The actual milk samples were detected by the addition method and compared with the high-performance liquid phase method; no significant difference was found in the detection results. The working electrode prepared by cross-linking method not only extends the service life of the sensor, but also improves the sensitivity and reproducibility of the sensor. It can also be used to detect the Pen G residue in the actual milk samples repeatedly. Practical Application: In this study, an electrochemical sensor for the rapid detection of penicillin sodium in milk was prepared, which has good sensitivity and fast detection speed.

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“…Through the Randles–Sevick equation (Chokkareddy et al., 2020; Garcia‐Miranda Ferrari et al., 2018; Kilele et al., 2020):

I_{pa} = 2 . 69 \times 1 0^{5} A C n^{3 / 2} {D_{R}}^{1 / 2} {normalv}^{1 / 2}

Section: Resultsmentioning

confidence: 96%

Penicillin biosensor based on rhombus‐shaped porous carbon/hematoxylin/penicillinase

Wang

Xiu

et al. 2021

Journal of Food Science

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“…Electrode sensing was tremendous at pH 6 in acidic conditions to reduce PZM at − 0.82 V vs SCE. DL and QL were 0.0102 µM and 0.3658 µM, respectively (Chokkareddy et al, 2021 ). Chokkareddy et al designed ionic liquid assimilated MWCN as support for nanoparticles of Co-ferrite decorated over GCE.…”

Section: Types Of Drugsmentioning

confidence: 99%

“…Optimum electrochemical detection of PZM was observed at − 0.82 V potential and pH 6. The method was claimed to be very sensitive with DL of 0.0102 µM (Chokkareddy et al, 2021 ).…”

Section: Types Of Drugsmentioning

confidence: 99%

Metal–Organic Framework-Based Composites for the Detection and Monitoring of Pharmaceutical Compounds in Biological and Environmental Matrices

Rizwan

Selvanathan

Rasool

et al. 2022

Water Air Soil Pollut

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The production of synthetic drugs is considered a huge milestone in the healthcare sector, transforming the overall health, aging, and lifestyle of the general population. Due to the surge in production and consumption, pharmaceutical drugs have emerged as potential environmental pollutants that are toxic with low biodegradability. Traditional chromatographic techniques in practice are time-consuming and expensive, despite good precision. Alternatively, electroanalytical techniques are recently identified to be selective, rapid, sensitive, and easier for drug detection. Metal–organic frameworks (MOFs) are known for their intrinsic porous nature, high surface area, and diversity in structural design that provides credible drug-sensing capacities. Long-term reusability and maintaining chemo-structural integrity are major challenges that are countered by ligand–metal combinations, optimization of synthetic conditions, functionalization, and direct MOFs growth over the electrode surface. Moreover, chemical instability and lower conductivities limited the mass commercialization of MOF-based materials in the fields of biosensing, imaging, drug release, therapeutics, and clinical diagnostics. This review is dedicated to analyzing the various combinations of MOFs used for electrochemical detection of pharmaceutical drugs, comprising antibiotics, analgesics, anticancer, antituberculosis, and veterinary drugs. Furthermore, the relationship between the composition, morphology and structural properties of MOFs with their detection capabilities for each drug species is elucidated.

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“…Ionic liquids (ILs) as a new green media composed of only ions with high ionic conductivity, negligible vapour pressure, high thermal stability, wide potential range, good electrochemical stability, reducing charging current thus improving the sensitivity of the sensors [24] . In literature ILs have been used as binders and modifiers with nanoparticles chemically modified electrodes in electrochemical determination of pharmaceutical drugs [25–30] . Nano materials sensors modified with ionic liquid will increase the rate of electron transfer, enable functional tunability, able to self‐assemble, good electrical optical and catalytic properties, thus resulting in tremendous gains in terms of selectivity, sensitivity, and versatility [31] .…”

Section: Introductionmentioning

confidence: 99%

“…[24] In literature ILs have been used as binders and modifiers with nanoparticles chemically modified electrodes in electrochemical determination of pharmaceutical drugs. [25][26][27][28][29][30] Nano materials sensors modified with ionic liquid will increase the rate of electron transfer, enable functional tunability, able to self-assemble, good electrical optical and catalytic properties, thus resulting in tremendous gains in terms of selectivity, sensitivity, and versatility. [31] The ZDV is an electroactive molecule, but nothing has been reported regarding its electrochemical behaviour using the ionic liquid-based sensor to pharmaceutical dosage forms.…”

Section: Introductionmentioning

confidence: 99%

An Efficient Sensor for the Detection of Zidovudine Based on 1‐Ethyl‐3‐methylimidazolium 1,1,2,2‐tetrafluoroethanesulfonate/ZnO Nanoparticle/MWCNT Glassy Carbon Electrodes**

Xhakaza

Chokkareddy

2021

ChemistrySelect

Self Cite

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A sensitive, low cost and novel electrochemical sensor based on 1‐ethyl‐3‐methylimidazolium 1,1,2,2‐tetrafluoroethanesulfonate ionic liquid (EmimTFES) combined with multi‐walled carbon nanotubes (MWCNTs) and zinc oxide nanoparticles (ZnONPs) in order to modify the glassy carbon electrode (GCE), has been developed for the first time. It was assessed that this sensor can be used for the rapid detection of the pharmaceutically antiretroviral drug zidovudine (ZDV). The characterization of ZnONPs, MWCNTs‐ZnONPs and MWCNTs‐ZnONPs‐EmimTFES was performed using Transmission electron microscopy (TEM), Ultraviolet Visible spectrophotometer (UV‐Vis), Fourier‐transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and Thermogravimetric analysis (TGA). The electrochemical of behaviour of MWCNTs‐ZnONPs‐EmimTFES‐GCE was studied using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The proposed sensor shows high electrocatalytic activity towards ZDV reduction over the concentration range of 0.2 μM to 2.0 μM. In addition, the limit of detection (LOD) of 0.0029 μM and limit of quantification (LOQ) of 0.0416 μM was obtained. Under optimal conditions the ionic liquid‐based sensor showed high selectivity, stability and sensitivity for ZDV detection, making it a suitable sensor for rapid determination of ZDV.

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A novel ionic liquid based electrochemical sensor for detection of pyrazinamide

Cited by 18 publications

References 40 publications

Penicillin biosensor based on rhombus‐shaped porous carbon/hematoxylin/penicillinase

Penicillin biosensor based on rhombus‐shaped porous carbon/hematoxylin/penicillinase

Metal–Organic Framework-Based Composites for the Detection and Monitoring of Pharmaceutical Compounds in Biological and Environmental Matrices

An Efficient Sensor for the Detection of Zidovudine Based on 1‐Ethyl‐3‐methylimidazolium 1,1,2,2‐tetrafluoroethanesulfonate/ZnO Nanoparticle/MWCNT Glassy Carbon Electrodes**

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