A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis

Abstract

L-ascorbic acid (Vitamin C) and peptide are both useful compounds for collagen biosynthesis in cosmeceuticals (cosmetic and pharmaceutical fields). The instability of these compounds, however, limit their application in these industries. In this report, we describe the development of a novel compound, Stabilized Ascorbyl Pentapeptide (SAP), which physically is much more stable than L-ascorbic acid in water. The inhibitory effects of this SAP compound on tyrosinase and melanin synthesis is comparable to that of L-ascorbic acid. Importantly, the SAP compound displays no cytotoxicity at a high concentration (5 mM). The ability of SAP to promote collagen biosynthesis is greater than that of L-ascorbic acid or the KTTKS peptide alone. Considering the in vitro stability and functional effects, our data strongly suggest that the SAP compound is a good candidate not only as a cosmetic ingredient, but also as a wound healing agent. [BMB reports 2009; 42(11): 743-746]

Vitamin C Enhances Nanog Expression Via Activation of the JAK/STAT Signaling Pathway

“…Vc was found to function in the prevention and treatment of colds, and antivirus, and in antiaging products as well as the prevention and auxiliary treatment of cancer . With further developments in research, additional functional roles of Vc have been identified.…”

Antioxidants as an Epidermal Stem Cell Activator

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Action of ascorbic acid on the healing of malnourished rats'skin wounds

“…After many substances are placed disorderly on the scar, including collagen, the wound is restructured, or ordered. More fibroblasts and collagen fibers appear in the lesion 27 . Ascorbic acid is important in this process because hydroxylases do not function in its absence and consequently, hydroxyproline, hydroxylysine, and collagen are not formed 27 .…”