A novel l-leucine modified Sol-Gel-Carbon electrode for simultaneous electrochemical detection of homovanillic acid, dopamine and uric acid in neuroblastoma diagnosis

Khamlichi, Redouan El; Bouchta, Dounia; Anouar, El Hassane; Atia, Mounia Ben; Attar, Aisha; Choukairi, Mohamed; Tazi, Saloua; Raissouni, Ihssane; Chaoukat, Faiza; Draoui, Khalid; Khalid, Riffi Temsamani

doi:10.1016/j.msec.2016.10.076

Cited by 21 publications

(8 citation statements)

References 20 publications

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“…A relationship for NR concentration and anodic current response was witnessed in two linear ranges as constructed in Figure (b). The appearance of two linear dynamic ranges during DPV quantification has been previously reported . It is plausibly caused by kinetic limitations of transport mechanism towards electrode surface in diffusion mode.…”

Section: Resultsmentioning

confidence: 99%

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

Manasa¹,

Mascarenhas²,

Bhakta

et al. 2019

Electroanalysis

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Naringenin (NR) displays strong antioxidant and numerous pharmacological activities, mitigating severity of metabolic‐syndromes without undesirable side‐effects. With the upsurge of interest in administering NR as diet‐supplement antioxidant, in this work for the first time we implemented functionalized‐MWCNT/Nileblue‐composite on carbon paste electrode (fMWNCT/NB/MCPE), as electrochemical sensor for catalytic NR oxidation. Integrated properties of fMWCNT/NB and their consonance with CPE, led to lowering of Rct value with fast‐kinetics and diminution of over‐potential. NR determination was due to electrical‐conductivity, π‐π and electrostatic‐forces that magnified anodic current by 5.5 fold. In the pH range 3.0 to 10.0 NR undergoes irreversible oxidation via transfer of 1e−/H+. Critical parameters, namely, pH and scan rate were assessed to reinforce differential pulse voltammtery (DPV) sensitivity for quantitative measurements. Sensor's selectivity, stability, accuracy and reproducibility were determined. Finally its viability in quantifying NR was validated by scrutinizing NR fortified fruit juices, as real sample matrices.

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Section: Resultsmentioning

confidence: 99%

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

Manasa¹,

Mascarenhas²,

Bhakta

et al. 2019

Electroanalysis

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“…Troeger's/SPE PB pH 7.0 DPV 2.2 [49] L-leucine modified Sol-Gel-Carbon electrode PB pH 7.4 DPV 0.1 [50] Cu/GCE PB pH 7.2 SWV 1.0×10 −2 [51] Boron doped diamond electrode 0.1 mol L -1 1 HCl DPV 0.4 [52] Metal-doped zirconia /CPE BR pH 4 DPV 0.273 This work…”

Section: Electrochemical Application: Detection Of Cancer Biomarkersmentioning

confidence: 99%

Synthesis and characterization of nanostructured copper and lanthanum co‐doped zirconia for voltammetric sensing of tumor biomarkers

Abbas

Radwan

Khaled

et al. 2021

Electrochemical Science Adv

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Nanostructured ZrO 2 -based materials with their biocompatibility, excellent electrical, and surface charge properties became one of the best candidates for the electrochemical sensing applications. Here, synthesis of Zr 1-x Cu x La x O 2 compounds was achieved in nanoscale and fully characterized using XRD, TEM, DRS, and cyclic voltammetry. A mixture of monoclinic and cubic phases was detected for the undoped ZrO 2 (Z sample, x = 0). For the Cu-doped compounds, (ZFW1, x = 0.05 and ZFW2, x = 0.1), a combination of cubic fluorite and monoclinic phase were detected. The intensity of the monoclinic phase for the Cudoped was higher than that of the undoped ZrO 2 sample. Cu and La co-doped samples (ZL1C1, x = 0.05 and ZL2C2, x = 0.1) were stabilized in a single cubic phase structure. Therefore, their band gap dropped from (4.8 eV) for the undoped ZrO 2 to (1.49 eV) for the ZL1C1 sample and (2 eV) for the ZL2C2 sample. Voltammetric sensing of neurotransmitter metabolites (vanillylmandelic acid (VMA) and homovanillic acid (HVA)) was achieved using the modified electrodes due to their acquired high electrocatalytic and high electrochemical performance.

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“…So far, the search for a suitable design of synthetic receptors to detect neuroblastoma markers and suitable approaches to their deposition on an electrode surface is a work in progress. The known receptors for the recognition of VMA/HVA include metaiodobenzylguanidine (mIBG) [ 7 ], α-cyclodextrin (α-CD) [ 8 ], and L-Leucine [ 9 ]. Protocols for the deposition of a receptor in the form of polymeric films derived from Tröger’s base [ 10 ], neutral red [ 11 ], and a cobalt bis(dicarbollide) derivative have been proposed [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode

Shishkanova

Králík

Synytsya

2023

Sensors

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Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are diagnostic markers of neuroblastoma. The purpose of this study was to understand the reason for the discrimination of structural analogues (VMA and HVA) onto a graphite electrode coated with an electrochemically oxidized urea derivative. Density functional theory calculations (DFT), FTIR spectroscopic measurements, and electrochemical impedance spectroscopic measurements were used in this work. Density functional theory calculations (DFT) were used to identify the most suitable binding sites of the urea derivative and to describe possible differences in its interaction with the studied analytes. The FTIR measurement indicated the enhancement and disappearance of NH vibrations on graphite and platinum surfaces, respectively, that could be connected to a different orientation and thus provide accessibility of the urea moiety for the discrimination of carboxylates. Additionally, the higher the basicity of the anion, the stronger the hydrogen-bonding interaction with –NH-groups of the urea moiety: VMA (pKb = 10.6, KAds = (5.18 ± 1.95) × 105) and HVA (pKb = 9.6, KAds = (4.78 ± 1.58) × 104). The differential pulse voltammetric method was applied to detect VMA and HVA as individual species and interferents. As individual analytes, both HVA and VMA can be detected at a concentration of 1.99 × 10−5 M (RSD ≤ 0.28, recovery 110–115%).

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A novel l-leucine modified Sol-Gel-Carbon electrode for simultaneous electrochemical detection of homovanillic acid, dopamine and uric acid in neuroblastoma diagnosis

Cited by 21 publications

References 20 publications

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

MWCNT/Nileblue Heterostructured Composite Electrode for Flavanone Naringenin Quantification in Fruit Juices

Synthesis and characterization of nanostructured copper and lanthanum co‐doped zirconia for voltammetric sensing of tumor biomarkers

Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode

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